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Volumn 58, Issue 6, 2013, Pages 1125-1132

Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function

Author keywords

Bacterial translocation; Cirrhosis; Epithelial barrier; IL 6; Intestinal macrophages; Nitric oxide

Indexed keywords

CD14 ANTIGEN; CD33 ANTIGEN; CHEMOKINE; CLAUDIN 2; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRIC OXIDE; IL6 PROTEIN, HUMAN;

EID: 84877924539     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.01.038     Document Type: Article
Times cited : (147)

References (30)
  • 1
    • 77957327198 scopus 로고    scopus 로고
    • Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis
    • V. Arvaniti, G. D'Amico, G. Fede, P. Manousou, E. Tsochatzis, and M. Pleguezuelo Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis Gastroenterology 139 2010 1246 1256
    • (2010) Gastroenterology , vol.139 , pp. 1246-1256
    • Arvaniti, V.1    D'Amico, G.2    Fede, G.3    Manousou, P.4    Tsochatzis, E.5    Pleguezuelo, M.6
  • 2
    • 58149399422 scopus 로고    scopus 로고
    • Serum and ascitic fluid bacterial DNA: A new independent prognostic factor in noninfected patients with cirrhosis
    • P. Zapater, R. Francés, J.M. González-Navajas, M.A. de la Hoz, R. Moreu, and S. Pascual Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis Hepatology 48 2008 1924 1931
    • (2008) Hepatology , vol.48 , pp. 1924-1931
    • Zapater, P.1    Francés, R.2    González-Navajas, J.M.3    De La Hoz, M.A.4    Moreu, R.5    Pascual, S.6
  • 3
    • 78649624916 scopus 로고    scopus 로고
    • Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis
    • P. Bellot, J.C. García-Pagán, R. Francés, J.G. Abraldes, M. Navasa, and M. Perez-Mateo Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis Hepatology 52 2010 2044 2052
    • (2010) Hepatology , vol.52 , pp. 2044-2052
    • Bellot, P.1    García-Pagán, J.C.2    Francés, R.3    Abraldes, J.G.4    Navasa, M.5    Perez-Mateo, M.6
  • 4
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • J.R. Turner Intestinal mucosal barrier function in health and disease Nat Rev Immunol 9 2009 799 809
    • (2009) Nat Rev Immunol , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 6
    • 79960772834 scopus 로고    scopus 로고
    • Epithelial barriers in intestinal inflammation
    • L.J. John, M. Fromm, and J.D. Schulzke Epithelial barriers in intestinal inflammation Antioxid Redox Signal 15 2011 1255 1270
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1255-1270
    • John, L.J.1    Fromm, M.2    Schulzke, J.D.3
  • 7
    • 80052400212 scopus 로고    scopus 로고
    • IL-6 regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • T. Suzuki, N. Yoshinaga, and S. Tanabe IL-6 regulates claudin-2 expression and tight junction permeability in intestinal epithelium J Biol Chem 286 2011 31263 31271
    • (2011) J Biol Chem , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 8
    • 13744256812 scopus 로고    scopus 로고
    • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    • L.E. Smythies, M. Sellers, R.H. Clements, M. Mosteller-Barnum, G. Meng, and W.H. Benjamin Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity J Clin Invest 115 2005 66 75
    • (2005) J Clin Invest , vol.115 , pp. 66-75
    • Smythies, L.E.1    Sellers, M.2    Clements, R.H.3    Mosteller-Barnum, M.4    Meng, G.5    Benjamin, W.H.6
  • 10
    • 45749107055 scopus 로고    scopus 로고
    • Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
    • N. Kamada, T. Hisamatsu, S. Okamoto, H. Chinen, T. Kobayashi, and T. Sato Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis J Clin Invest 118 2008 2269 2280
    • (2008) J Clin Invest , vol.118 , pp. 2269-2280
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3    Chinen, H.4    Kobayashi, T.5    Sato, T.6
  • 11
    • 34250003717 scopus 로고    scopus 로고
    • Interferon-γ inhibits intestinal restitution by preventing gap junction communication between enterocytes
    • C.L. Leaphart, F. Qureshi, S. Cetin, J. Li, T. Dubowski, and C. Batey Interferon-γ inhibits intestinal restitution by preventing gap junction communication between enterocytes Gastroenterology 132 2007 2395 2411
    • (2007) Gastroenterology , vol.132 , pp. 2395-2411
    • Leaphart, C.L.1    Qureshi, F.2    Cetin, S.3    Li, J.4    Dubowski, T.5    Batey, C.6
  • 13
    • 77955690397 scopus 로고    scopus 로고
    • Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy
    • E. Cassol, S. Malfeld, P. Mahasha, S. van der Merwe, S. Cassol, and C. Seebregts Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy J Infect Dis 202 2010 723 733
    • (2010) J Infect Dis , vol.202 , pp. 723-733
    • Cassol, E.1    Malfeld, S.2    Mahasha, P.3    Van Der Merwe, S.4    Cassol, S.5    Seebregts, C.6
  • 14
    • 18744414535 scopus 로고    scopus 로고
    • Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon
    • C. Wallon, Y. Braaf, M. Wolving, G. Olaison, and J.D. Söderholm Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon Scand J Gastroenterol 40 2005 586 595
    • (2005) Scand J Gastroenterol , vol.40 , pp. 586-595
    • Wallon, C.1    Braaf, Y.2    Wolving, M.3    Olaison, G.4    Söderholm, J.D.5
  • 15
    • 80053606297 scopus 로고    scopus 로고
    • Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection
    • N.G. Sandler, C. Koh, A. Roque, J.L. Eccleston, R.B. Siegel, and M. Demino Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection Gastroenterology 141 2011 1220 1230
    • (2011) Gastroenterology , vol.141 , pp. 1220-1230
    • Sandler, N.G.1    Koh, C.2    Roque, A.3    Eccleston, J.L.4    Siegel, R.B.5    Demino, M.6
  • 16
    • 33748928776 scopus 로고    scopus 로고
    • The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation
    • C. Guarner, J.M. González-Navajas, E. Sánchez, G. Soriando, R. Frances, and M. Chiva The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation Hepatology 44 2006 633 639
    • (2006) Hepatology , vol.44 , pp. 633-639
    • Guarner, C.1    González-Navajas, J.M.2    Sánchez, E.3    Soriando, G.4    Frances, R.5    Chiva, M.6
  • 17
    • 34548487937 scopus 로고    scopus 로고
    • Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis
    • J. Fernández, M. Navasa, R. Planas, S. Montoliu, D. Monfort, and G. Soriano Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis Gastroenterology 133 2007 818 824
    • (2007) Gastroenterology , vol.133 , pp. 818-824
    • Fernández, J.1    Navasa, M.2    Planas, R.3    Montoliu, S.4    Monfort, D.5    Soriano, G.6
  • 18
    • 33749042572 scopus 로고    scopus 로고
    • The intestinal flora and bacterial infection in cirrhosis
    • S.M. Riordan, and R. Williams The intestinal flora and bacterial infection in cirrhosis Hepatology 45 2006 744 757
    • (2006) Hepatology , vol.45 , pp. 744-757
    • Riordan, S.M.1    Williams, R.2
  • 19
    • 18844365431 scopus 로고    scopus 로고
    • Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism
    • R. Yang, T. Harada, J. Li, T. Uchiyama, Y. Han, and J.A. Englert Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism Intensive Care Med 31 2005 709 717
    • (2005) Intensive Care Med , vol.31 , pp. 709-717
    • Yang, R.1    Harada, T.2    Li, J.3    Uchiyama, T.4    Han, Y.5    Englert, J.A.6
  • 20
    • 34948821265 scopus 로고    scopus 로고
    • Trem-1 expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
    • M. Schenk, A. Bouchon, F. Seibold, and C. Mueller Trem-1 expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases J Clin Invest 117 2007 3097 3106
    • (2007) J Clin Invest , vol.117 , pp. 3097-3106
    • Schenk, M.1    Bouchon, A.2    Seibold, F.3    Mueller, C.4
  • 21
    • 77952784918 scopus 로고    scopus 로고
    • Cutting edge: IFN-γ is a negative regulator of IL-23 in murine macrophages and experimental colitis
    • S.Z. Sheikh, K. Matsuoka, T. Kobayashi, F. Li, T. Rubinas, and S.E. Plevy Cutting edge: IFN-γ is a negative regulator of IL-23 in murine macrophages and experimental colitis J Immunol 184 2010 4069 4073
    • (2010) J Immunol , vol.184 , pp. 4069-4073
    • Sheikh, S.Z.1    Matsuoka, K.2    Kobayashi, T.3    Li, F.4    Rubinas, T.5    Plevy, S.E.6
  • 22
    • 45949108853 scopus 로고    scopus 로고
    • The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells
    • A.R. Anand, M. Cucchiarini, E.F. Terwilliger, and R.K. Ganju The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells J Immunol 180 2008 5636 5644
    • (2008) J Immunol , vol.180 , pp. 5636-5644
    • Anand, A.R.1    Cucchiarini, M.2    Terwilliger, E.F.3    Ganju, R.K.4
  • 23
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    • H.M. Martin, B.J. Campbell, C.A. Hart, C. Mpofu, M. Nayar, and R. Singh Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer Gastroenterology 127 2004 80 93
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.M.1    Campbell, B.J.2    Hart, C.A.3    Mpofu, C.4    Nayar, M.5    Singh, R.6
  • 24
    • 84868136560 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor i contribute to liver fibrosis in mice
    • P. Hartmann, M. Haimerl, M. Mazagova, D.A. Brenner, and B. Schnabl Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice Gastroenterology 143 2012 1330 1340
    • (2012) Gastroenterology , vol.143 , pp. 1330-1340
    • Hartmann, P.1    Haimerl, M.2    Mazagova, M.3    Brenner, D.A.4    Schnabl, B.5
  • 25
    • 79953174256 scopus 로고    scopus 로고
    • The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    • A.M. Marchiando, L. Shen, W.V. Graham, K.L. Edelblum, C.A. Duckworth, and Y. Guan The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding Gastroenterology 140 2011 1208 1218
    • (2011) Gastroenterology , vol.140 , pp. 1208-1218
    • Marchiando, A.M.1    Shen, L.2    Graham, W.V.3    Edelblum, K.L.4    Duckworth, C.A.5    Guan, Y.6
  • 26
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • S. Zeissig, N. Bürgel, D. Günzel, J. Richter, J. Mankertz, and U. Wahnschaffe Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease Gut 56 2007 61 72
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Bürgel, N.2    Günzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6
  • 27
    • 78049291281 scopus 로고    scopus 로고
    • A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection
    • A.J. Smith, T.W. Schacker, C.S. Reilly, and A.T. Haase A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection J Acquir Immune Defic Syndr 55 2010 306 315
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 306-315
    • Smith, A.J.1    Schacker, T.W.2    Reilly, C.S.3    Haase, A.T.4
  • 28
    • 0036202862 scopus 로고    scopus 로고
    • Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: Role of iNOS and COX-2
    • S. Resta-Lenert, and K.E. Barrett Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2 Gastroenterology 122 2002 1070 1087
    • (2002) Gastroenterology , vol.122 , pp. 1070-1087
    • Resta-Lenert, S.1    Barrett, K.E.2
  • 29
    • 2642576322 scopus 로고    scopus 로고
    • Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice
    • X. Han, M.P. Fink, R. Yang, and R.L. Delude Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice Shock 21 2004 261 270
    • (2004) Shock , vol.21 , pp. 261-270
    • Han, X.1    Fink, M.P.2    Yang, R.3    Delude, R.L.4
  • 30
    • 0030699109 scopus 로고    scopus 로고
    • Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth
    • S. Mishima, D. Xu, Q. Lu, and E.A. Deitch Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth Arch Surg 132 1997 1190 1195
    • (1997) Arch Surg , vol.132 , pp. 1190-1195
    • Mishima, S.1    Xu, D.2    Lu, Q.3    Deitch, E.A.4


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