Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages

Cancer Research

Volumn 73, Issue 10, 2013, Pages 3019-3028

  Osawa, Tsuyoshi ^a,b,e   Tsuchida, Rika ^e   Muramatsu, Masashi ^e,f   Shimamura, Teppei ^d   Wang, Feng ^e   Suehiro, Jun Ichi ^a   Kanki, Yasuharu ^b   Wada, Youichiro ^b   Yuasa, Yasuhito ^e   Aburatani, Hiroyuki ^c   Miyano, Satoru ^d   Minami, Takashi ^a   Kodama, Tatsuhiko ^b   Shibuya, Masabumi ^e,g  

^a Laboratory for Vascular Biology   (Japan)

^b Laboratory for Systems Biology and Medicine   (Japan)

^c RCAST   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^f ROSWELL PARK CANCER INSTITUTE   (United States)

^g JOBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CELL PROTEIN; FIBROBLAST GROWTH FACTOR 18; HISTONE DEMETHYLASE; JUMONJI DOMAIN CONTAINING PROTEIN 1A; PROTEIN ANG2; PROTEIN EGF2; PROTEIN KINASE B; SCATTER FACTOR; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC THERAPY; ARTICLE; CANCER INHIBITION; CELL HYPOXIA; CELL INFILTRATION; CELL INVASION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPIGENETICS; GENETIC REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE MIGRATION; MALIGNANT NEOPLASTIC DISEASE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MACROPHAGES; MICE; MICE, INBRED C57BL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84877855147     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3231     Document Type: Article

References (34)

1. Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74. (Pubitemid 43093963)
2. Carmeliet P. Angiogenesis in health and disease. Nature Med 2003;9:653-60. (Pubitemid 36749213)
3. Risaw W. Mechanism of angiogenesis. Nature 1997;386:671-4.
4. Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 2006;312:549-60. (Pubitemid 43290332)
5. Folkman J. Angiogenesis: An organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86. (Pubitemid 46505878)
6. Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-31.
7. Ebos JML, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a patient inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.
8. Osawa T, Muramatsu M, Watanabe M, Shibuya M. Hypoxia and low nutrition double stress induces aggressiveness in a murine model of melanoma. Cancer Sci 2009;100:844-51.
9. Osawa T, Tsuchida R, Muramatsu M, Yuasa Y, Shibuya M. Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T cell leukemia in mice. Blood Cancer J 2011;1:e6.
10. Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, et al. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via downregulating angiogenesis. Proc Natl Acad Sci USA 2011;108:20725-9.
11. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
12. Muramatsu M, Yamamoto S, Osawa T, Shibuya M. VEGFR-1 signaling promotes mobilization of macrophage-linage cells from bone marrow and stimulates solid tumor growth. Cancer Res 2010;70:8211-21.
13. Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2002;2:289-300. (Pubitemid 41043963)
14. Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M. Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci 2011;102:2007-13.
15. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-4. (Pubitemid 23132159)
16. Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005;307:58-62. (Pubitemid 40093472)
17. Shojaei F, Wu X, Qu X, Kowanetz M, Yu L, Tan M, et al. G-CSF initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci USA 2009;106:6742-7.
18. Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309. (Pubitemid 41443415)
19. De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 2005;8:211-26. (Pubitemid 41317592)
20. Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
21. Gupta GP, Massague J. Cancer metastasis: Building a framework. Cell 2006;127:679-95. (Pubitemid 44781029)
22. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009;324:1029-33.
23. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891-9. (Pubitemid 39472955)
24. DeBerardinis RJ, Thompson CB. Cellular metabolism and disease: What do metabolic outliers teach us? Cell 2012;148:1132-44.
25. Sokawa Y, Sokawa J, Kaziro Y. Role of rel gene in translation during amino acid starvation in Escherichia coli. Nature 1974;249: 59-62.
26. Shibuya M, Kaziro Y. Studies on stringent control in a cell-free system. Regulation by guanosine-50-diphosphate-30-diphosphate of the synthesis of elongation factor Tu. J Biochem 1979;86:403-11.
27. Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer 2011;11: 726-34.
28. Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, et al. Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat Commun 2012;3:883.
29. Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 2007;450:119-23. (Pubitemid 350070569)
30. Tateishi K, Okada Y, Kallin EM, Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009;458: 757-61.
31. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol 2010;30:344-53.
32. Uemura M, Yamamoto H, Takemasa I, Mimori K, Hemmi H, Mizushima T, et al. Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: In vivo identification from hypoxic tumor cells. Clin Cancer Res 2010;16:4636-46.
33. Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009;10:165-77.
34. Yoo PB, Jones PA. Epigenetic therapy of cancer: Past, present and future. Nat Rev Drug Discov 2006;5:37-50.