Immunotherapy with a recombinant hybrid molecule alleviates allergic responses more efficiently than an allergenic cocktail or pollen extract in a model of Chenopodium album allergy

International Archives of Allergy and Immunology

Volumn 161, Issue 4, 2013, Pages 325-332

  Nouri, Hamid Reza ^a   Sankian, Mojtaba ^b   Afsharzadeh, Danial ^b   Varasteh, Abdolreza ^c  

^a BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allergen specific immunotherapy; Allergenic cocktail; Recombinant hybrid molecule

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ANTIALLERGIC AGENT; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 4; POLLEN EXTRACT; RECOMBINANT HYBRID MOLECULE; UNCLASSIFIED DRUG; ALLERGENIC COCKTAIL; BLOCKING ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 13; MESSENGER RNA; POLLEN ANTIGEN; RECOMBINANT ALLERGEN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3;

ALLERGIC REACTION; ANIMAL CELL; ARTICLE; CHENOPODIUM ALBUM; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMORAL IMMUNITY; IMMUNOGENICITY; IMMUNOTHERAPY; IN VITRO STUDY; MOUSE; NONHUMAN; POLLEN ALLERGY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL; TH1 CELL; TH2 CELL; WILD TYPE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIGEN ANTIBODY COMPLEX; CELL PROLIFERATION; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; PRICK TEST; PROTEIN SECRETION; SENSITIZATION; SKIN MANIFESTATION; SKIN TEST; SUBCUTANEOUS IMMUNOTHERAPY; TH1 TH2 BALANCE; TREATMENT RESPONSE;

ALLERGENS; ANIMALS; ANTIGENS, PLANT; CELLS, CULTURED; CHENOPODIUM ALBUM; DESENSITIZATION, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOGLOBULIN E; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; RECOMBINANT PROTEINS; RHINITIS, ALLERGIC, SEASONAL; T-LYMPHOCYTES; TH1-TH2 BALANCE;

EID: 84877853136     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000347136     Document Type: Article

References (36)

1. Barderas R, Villalba M, Lombardero M, Rodriguez R: Identification and characterization of Che a 1 allergen from Chenopodium album pollen. Int Arch Allergy Immunol 2002; 127: 47-54
2. Ring J, Gutermuth J: 100 years of hyposensitization: History of allergen-specific immunotherapy (ASIT). Allergy 2011; 66: 713-724
3. Durham SR: Allergen immunotherapy (desensitisation) for allergic diseases. Clin Med 2006; 6: 348-351
4. Cox L: Allergen immunotherapy: Immunomodulatory treatment for allergic diseases. Expert Rev Clin Immunol 2006; 2: 533-546
5. Valenta R, Linhart B, Swoboda I, Niederberger V: Recombinant allergens for allergen-specific immunotherapy: 10 years anniversary of immunotherapy with recombinant allergens. Allergy 2011; 66: 775-783
6. Cromwell O, Hafner D, Nandy A: Recombinant allergens for specific immunother apy. J Allergy Clin Immunol 2011; 127: 865-872
7. Vrtala S, Focke-Tejkl M, Swoboda I, Kraft D, Valenta R: Strategies for converting allergens into hypoallergenic vaccine candidates. Methods 2004; 32: 313-320
8. Thomas WR, Hales BJ, Smith WA: Genetically engineered vaccines. Curr Allergy Asthma Rep 2005; 5: 197-203
9. Linhart B, Valenta R: Vaccine engineering improved by hybrid technology. Int Arch Allergy Immunol 2004; 134: 324-331
10. Linhart B, Jahn-Schmid B, Verdino P, Keller W, Ebner C, Kraft D, Valenta R: Combination vaccines for the treatment of grass pollen allergy consisting of genetically engineered hybrid molecules with increased immunogenicity. FASEB J 2002; 16: 1301-1303
11. Larche M, Akdis CA, Valenta R: Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006; 6: 761- 771
12. Pauli G, Malling HJ: Allergen-specific immunotherapy with recombinant allergens. Curr Top Microbiol Immunol 2011; 352: 43-54
13. Nouri HR, Sankian M, Vahedi F, Afsharzadeh D, Rouzbeh L, Moghadam M, Varasteh A: Diagnosis of Chenopodium album allergy with a cocktail of recombinant allergens as a tool for component-resolved diagnosis. Mol Biol Rep 2012; 39: 3169-3178
14. Bonura A, Corinti S, Artale A, Di Felice G, Amoroso S, Melis M, Geraci D, Colombo P: A hybrid expressing genetically engineered major allergens of the Parietaria pollen as a tool for specific allergy vaccination. Int Arch Allergy Immunol 2007; 142: 274- 284
15. Linhart B, Hartl A, Jahn-Schmid B, Verdino P, Keller W, Krauth MT, Valent P, Horak F, Wiedermann U, Thalhamer J, Ebner C, Kraft D, Valenta R: A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol 2005; 115: 1010-1016
16. Nouri HR, Varasteh A, Vahedi F, Chamani J, Afsharzadeh D, Sankian M: Constructing a hybrid molecule with low capacity of IgE binding from Chenopodium album pollen allergens. Immunol Lett 2012; 144: 67-77
17. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45
18. Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P, Reisinger J, Pelzmann M, Hayek B, Kronqvist M, Gafvelin G, Gronlund H, Purohit A, Suck R, Fiebig H, Cromwell O, Pauli G, van Hage-Hamsten M, Valenta R: Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci USA 2004; 101(suppl 2):14677-14682
19. Mahler V, Vrtala S, Kuss O, Diepgen TL, Suck R, Cromwell O, Fiebig H, Hartl A, Thalhamer J, Schuler G, Kraft D, Valenta R: Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1. Clin Exp Allergy 2004; 34: 115-122
20. Batanero E, Barral P, Villalba M, Rodriguez R: Sensitization of mice with olive pollen allergen Ole e 1 induces a Th2 response. Int Arch Allergy Immunol 2002; 127: 269-275
21. Herz U, Renz H, Wiedermann U: Animal models of type I allergy using recombinant allergens. Methods 2004; 32: 271-280
22. Ebner C, Siemann U, Bohle B, Willheim M, Wiedermann U, Schenk S, Klotz F, Ebner H, Kraft D, Scheiner O: Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from Th2 to Th1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 1997; 27: 1007-1015
23. Akdis CA, Blaser K: Mechanisms of allergenspecific immunotherapy. Allergy 2000; 55: 522-530
24. Vrtala S, Akdis CA, Budak F, Akdis M, Blaser K, Kraft D, Valenta R: T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies. J Immunol 2000; 165: 6653-6659
25. Linhart B, Mothes-Luksch N, Vrtala S, Kneidinger M, Valent P, Valenta R: A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6. Biol Chem 2008; 389: 925-933
26. Wachholz PA, Soni NK, Till SJ, Durham SR: Inhibition of allergen-IgE binding to B cells by Ig G antibodies after grass pollen immunothera py. J Allergy Clin Immunol 2003; 112: 915-922
27. Saarne T, Neimert-Andersson T, Gronlund H, Jutel M, Gafvelin G, van Hage M: Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy. Allergy 2011; 66: 255-263
28. Valenta R, Kraft D: Recombinant allergens: From production and characterization to diagnosis, treatment, and prevention of allergy. Methods 2004; 32: 207-208
29. Wu K, Bi Y, Sun K, Wang C: IL-10-producing type 1 regulatory T cells and allergy. Cell Mol Immunol 2007; 4: 269-275
30. Akdis CA, Joss A, Akdis M, Blaser K: Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens. Int Arch Allergy Immunol 2001; 124: 180-182
31. Zhu J, Yamane H, Cote-Sierra J, Guo L, Paul WE: Gata-3 promotes Th2 responses through three different mechanisms: Induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res 2006; 16: 3-10
32. Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-596
33. Vrtala S, Fohr M, Campana R, Baumgartner C, Valent P, Valenta R: Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination. Vaccine 2011; 29: 2140-2148
34. Velickovic TC, Jankov RM: Design and modifications of allergens for improving specific immunotherapy. Inflamm Allergy Drug Targets 2008; 7: 270-278
35. Akdis CA, Blaser K: Regulation of specific immune responses by chemical and structural modifications of allergens. Int Arch Allergy Immunol 2000; 121: 261-269
36. Linhart B, Valenta R: Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives. Vaccine 2012; 30: 4328-4335 Medical Sciences