Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis

Multiple Sclerosis Journal

Volumn 19, Issue 4, 2013, Pages 427-435

  Oh, Jiwon ^a   Zackowski, Kathleen ^a,b   Chen, Min ^a   Newsome, Scott ^a   Saidha, Shiv ^a   Smith, Seth A ^c   Diener West, Marie ^a   Prince, Jerry ^a   Jones, Craig K ^a,b   Van Zijl, Peter C M ^a,b   Calabresi, Peter A ^a   Reich, Daniel S ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Clinical dysfunction; Cross sectional area; Diffusion tensor imaging; Diffusivity; Fractional anisotropy; Magnetization transfer ratio; MRI; Multiple sclerosis; Spinal cord

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; EXPANDED DISABILITY STATUS SCALE; FEMALE; FRACTIONAL ANISOTROPY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; SENSORIMOTOR FUNCTION; SPINAL CORD;

EID: 84877845026     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458512456614     Document Type: Article

References (37)

1. Bot JC, Barkhof F, Polman CH, et al. Spinal cord abnormalities in recently diagnosed MS patients: Added value of spinal MRI examination. Neurol 2004; 62: 226-233. (Pubitemid 38167129)
2. Bergers E, Bot JC, Van der Valk P, et al. Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology. Ann Neurol 2002; 51: 652-656.
3. Nijeholt GJ, Bergers E, Kamphorst W, et al. Post-mortem high-resolution MRI of the spinal cord in multiple sclerosis: A correlative study with conventional MRI, histopathology and clinical phenotype. Brain 2001; 124: 154-166. (Pubitemid 32055997)
4. Smith SA, Jones CK, Gifford A, et al. Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla. NMR Biomed 2010; 23: 207-217.
5. Fox RJ, Beall E, Bhattacharyya P, et al. Advanced MRI in multiple sclerosis: Current status and future challenges. Neurologic Clinics 2011; 29: 357-380.
6. Barkhof F. The clinico-radiological paradox in multiple sclerosis revisited. Curr Op Neurol 2002; 15: 239-245. (Pubitemid 34596884)
7. Schmierer K, Scaravilli F, Altmann DR, et al. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 2004; 56: 407-415. (Pubitemid 39166560)
8. Newsome SD, Wang JI, Kang JY, et al. Quantitative measures detect sensory and motor impairments in multiple sclerosis. J Neurol Sci 2011; 305: 103-111.
9. Zackowski KM, Smith SA, Reich DS, et al. Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord. Brain 2009; 132: 1200-1209.
10. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121-127.
11. Lucas BC, Bogovic JA, Carass A, et al. The Java Image Science Toolkit (JIST) for rapid prototyping and publishing of neuroimaging software. Neuroinformat 2010; 8: 5-17.
12. Chen MCA, Wheeler MB, Liu X, et al. Multi-channel enhancement of the adaptive bases algorithm. In: 16th Annual meeting of the Organization for Human Brain Mapping 2010; Barcelona, Spain, 2010. Pages: 30, poster 807.
13. Rohde GK, Aldroubi A and Dawant BM. The adaptive bases algorithm for intensity-based nonrigid image registration. IEEE Transact Med Imaging 2003; 22: 1470-1479.
14. MCA Chen, Carass A, Cuzzocreo J, Bazin P-L, Reich DS, and Prince JL. Topology Preserving Automatic Segmentation of the Spinal Cord in Magnetic Resonance Images. Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on Biomedical Imaging, Chicago, IL, USA, March 30 - April 2, 2011, pp. 1737-1740.
15. Reich DS, Smith SA, Jones CK, et al. Quantitative characterization of the corticospinal tract at 3T. AJNR 2006; 27: 2168-2178. (Pubitemid 44788651)
16. Ozturk A, Smith SA, Gordon-Lipkin EM, et al. MRI of the corpus callosum in multiple sclerosis: Association with disability. Mult Scler 2010; 16: 166-177.
17. Harrison DM, Caffo BS, Shiee N, et al. Longitudinal changes in diffusion tensor-based quantitative MRI in multiple sclerosis. Neurol 2011; 76: 179-186.
18. Bender R and Lange S. Adjusting for multiple testing: When and how? J Clin Epidemiol 2001; 54: 343-349. (Pubitemid 32303457)
19. Huber PJ. The behavior of maximum likelihood estimates under non-standard conditions. In: Proceedings of the fifth Berkeley symposium on mathematical statistics and probability. Berkeley, CA: University of California Press, 1967, pp. 221-223.
20. White H. A heteroskedasticity consistent covariace matrix estimator and a direct test for heteroscedasticity. Econometrica 1980; 48: 817-830.
21. Agosta F, Absinta M, Sormani MP, et al. In vivo assessment of cervical cord damage in MS patients: A longitudinal diffusion tensor MRI study. Brain 2007; 130: 2211-2219. (Pubitemid 47236613)
22. Ciccarelli O, Wheeler-Kingshott CA, McLean MA, et al. Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain 2007; 130: 2220-2231. (Pubitemid 47236629)
23. Benedetti B, Rocca MA, Rovaris M, et al. A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients. J Neurol Neurosurg Psychiatry 2010; 81: 26-30.
24. Freund P, Wheeler-Kingshott C, Jackson J, et al. Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity. Mult Scler 2010; 16: 1193-1202.
25. Cohen AB, Neema M, Arora A, et al. The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimag 2011; 2: 122-128.
26. Rocca MA, Horsfield MA, Sala S, et al. A multicenter assessment of cervical cord atrophy among MS clinical phenotypes. Neurol 2011; 76: 2096-2102.
27. Hesseltine SM, Law M, Babb J, et al. Diffusion tensor imaging in multiple sclerosis: Assessment of regional differences in the axial plane within normal-appearing cervical spinal cord. AJNR 2006; 27: 1189-1193. (Pubitemid 44897623)
28. Silver NC, Barker GJ, Losseff NA, et al. Magnetisation transfer ratio measurement in the cervical spinal cord: A preliminary study in multiple sclerosis. Neuroradiol 1997; 39: 441-445. (Pubitemid 27252616)
29. Filippi M, Bozzali M, Horsfield MA, et al. A conventional and magnetization transfer MRI study of the cervical cord in patients with MS. Neurol 2000; 54: 207-213. (Pubitemid 30038761)
30. Farrell JA, Zhang J, Jones MV, et al. Q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy. Magnetic resonance in medicine : official journal of the Society of Mag Resonance Med 2010; 63: 1323-1335.
31. Landman BA, Farrell JA, Smith SA, et al. Complex geometric models of diffusion and relaxation in healthy and damaged white matter. NMR Biomed 2010; 23: 152-162.
32. Klawiter EC, Schmidt RE, Trinkaus K, et al. Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords. NeuroImage 2011; 55: 1454-1460.
33. Zollinger LV, Kim TH, Hill K, et al. Using diffusion tensor imaging and immunofluorescent assay to evaluate the pathology of multiple sclerosis. JMRI 2011; 33: 557-564.
34. Fox RJ. Picturing multiple sclerosis: Conventional and diffusion tensor imaging. Sem Neurol 2008; 28: 453-466.
35. Van Waesberghe JH, Kamphorst W, De Groot CJ, et al. Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability. Ann Neurol 1999; 46: 747-754. (Pubitemid 29518136)
36. Vavasour IM, Laule C, Li DK, et al. Is the magnetization transfer ratio a marker for myelin in multiple sclerosis? JMRI 2011; 33: 713-718.
37. Fisher E, Rudick RA, Cutter G, et al. Relationship between brain atrophy and disability: An 8-year follow-up study of multiple sclerosis patients. Mult Scler 2000; 6: 373-377. (Pubitemid 32106796)