Complement activation in pediatric patients with recurrent acute otitis media

International Journal of Pediatric Otorhinolaryngology

Volumn 77, Issue 6, 2013, Pages 911-917

  He, Yujuan ^a,c   Scholes, Melissa A ^b   Wiet, Gregory J ^a,b   Li, Qian ^a,d   Clancy, Caitlin ^a   Tong, Hua Hua ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

C3; C5a; Complement activation; Cytokine; Factor B; IAV; MEEs; NTHi; Otitis media; Spn

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; INTERLEUKIN 6; INTERLEUKIN 8; LECTIN;

ACUTE OTITIS MEDIA; ADENOIDECTOMY; ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENZYME ACTIVITY; HEARING IMPAIRMENT; HUMAN; HUMAN CELL; INFANT; MIDDLE EAR EFFUSION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECURRENT DISEASE;

ACUTE DISEASE; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHILD, PRESCHOOL; COHORT STUDIES; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C5; COMPLEMENT SYSTEM PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE EAR VENTILATION; OTITIS MEDIA WITH EFFUSION; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; RECURRENCE; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 84877835134     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2013.03.004     Document Type: Article

References (28)

1. Monasta L., Ronfani L., Marchetti F., Montico M., Vecchi Brumatti L., Bavcar A., et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS ONE 2012, 7:e36226.
2. Bluestone C.D., Stephenson J.S., Martin L.M. Ten-year review of otitis media pathogens. Pediatr. Infect. Dis. J. 1992, 11(Suppl. 8):11S7-S11.
3. Giebink G.S., Berzins I.K., Marker S.C., Schiffman G. Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas. Infect. Immun. 1980, 30:445-450.
4. Ricklin D., Hajishengallis G., Yang K., Lambris J.D. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 2010, 11:785-797.
5. Närkiö-Mäkelä M., Teppo A.M., Meri S. Complement C3 cleavage and cytokines interleukin-1beta and tumor necrosis factor-alpha in otitis media with effusion. Laryngoscope 2000, 110:1745-1749.
6. Närkiö-Mäkelä M., Jero J., Meri S. Complement activation and expression of membrane regulators in the middle ear mucosa in otitis media with effusion. Clin. Exp. Immunol. 1999, 116:401-409.
7. Närkiö-Mäkelä M., Meri S. Cytolytic complement activity in otitis media with effusion. Clin. Exp. Immunol. 2001, 124:369-376.
8. Li Q., Li Y.X., Stahl G.L., Thurman J.M., He Y., Tong H.H., et al. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect. Immun. 2011, 79:2578-2585.
9. Chung M.H., Griffith S.R., Park K.H., Lim D.J., DeMaria T.F. Cytological and histological changes in the middle ear after inoculation of influenza A virus. Acta Otolaryngol. 1993, 113:81-87.
10. Andersson B., Eriksson B., Falsen E., Fogh A., Hanson L.A., Nylen O., et al. Adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells in vitro: differences in adhesive capacity among strains isolated from subjects with otitis media, septicemia, or meningitis or from healthy carriers. Infect. Immun. 1981, 32:311-317.
11. Tong H.H., Chen Y., James M., Van Deusen L., Welling D.B., DeMaria T.F. Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants. Infect. Immun. 2001, 69:3678-3684.
12. Tong H.H., Long J.P., Shannon P.A., DeMaria T.F. Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by influenza A virus and Streptococcus pneumoniae opacity variants. Infect. Immun. 2003, 71:4289-4296.
13. Brown J.S., Hussell T., Gilliland S.M., Holden D.W., Paton J.C., Ehrenstein M.R., et al. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc. Natl. Acad. Sci. USA 2002, 99:16969-16974.
14. Harada T., Ogino S., Suzawa Y., Matsunaga T., Hong K.S., Inoue K. Complement anaphylatoxins activity in middle ear effusion. Auris Nasus Larynx 1985, 12(Suppl. 1):188-190.
15. Klos A., Tenner A.J., Johswich K.O., Ager R.R., Reis E.S., Köhl J. The role of the anaphylatoxins in health and disease. Mol. Immunol. 2009, 46:2753-2766.
16. Guo R.F., Ward P.A. Role of C5a in inflammatory responses. Annu. Rev. Immunol. 2005, 23:821-885.
17. Hollmann T.J., Mueller-Ortiz S.L., Braun M.C., Wetsel R.A. Disruption of the C5a receptor gene increases resistance to acute gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol. Immunol. 2008, 45:1907-1915.
18. Camous L., Roumenina L., Bigot S., Brachemi S., Frémeaux-Bacchi V., Lesavre P., et al. Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood 2011, 117:1340-1349.
19. Huber-Lang M., Sarma J.V., Zetoune F.S.F.S., Rittirsch D., Neff T.A., McGuire S.R., et al. Generation of C5a in the absence of C3: a new complement activation pathway. Nat. Med. 2006, 12:682-687.
20. Markiewski M.M., Nilsson B., Ekdahl K.N., Mollnes T.E., Lambris J.D. Complement and coagulation: strangers or partners in crime?. Trends Immunol. 2007, 28:184-192.
21. Bernstein L.M., Steger R., Back N. The kallikrein-kinint system in otitis media with effusion. Otolaryngology 1978, 86:ORL249-ORL255.
22. Bernstein J.M., Steger R., Back N. The fibrinolysin system in otitis media with effusion. Am. J. Otolaryngol. 1979, 1:28-33.
23. Woodruff T.M., Nandakumar K.S., Tedesco F.F. Inhibiting the C5-C5a receptor axis. Mol. Immunol. 2011, 48:1631-1642.
24. Woehrl B., Brouwer M.C., Murr C., Heckenberg S.G., Baas F., Pfister H.W., et al. Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J. Clin. Invest. 2011, 121:3943-3953.
25. Bolger M.S., Ross D.S., Jiang H., Frank M.M., Ghio A.J., Schwartz D.A., et al. Complement levels and activity in the normal and LPS-injured lung. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 292:L748-L759.
26. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media Diagnosis and management of acute otitis media. Pediatrics 2004, 113:1451-1465.
27. Hallstrom T., Rissbeck K. Haemophilis influenza and the complement system. Trends Microbiol. 2010, 18:258-265.
28. Ricklin D., Lambris J.D. Progress and trends in complement therapeutics. Adv. Exp. Med. Biol. 2013, 734:1-22.