메뉴 건너뛰기




Volumn 16, Issue 2, 2013, Pages 243-247

Immunomodulatory effects of silymarin in patients with β-thalassemia major

Author keywords

Cell mediated immunity; Cytokine; Immunomodulator; Lymphocyte; Silymarin; Thalassemia

Indexed keywords

COMPLEMENT; DEFEROXAMINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 4; NEOPTERIN; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84877819990     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.04.016     Document Type: Article
Times cited : (34)

References (34)
  • 5
    • 67650376406 scopus 로고    scopus 로고
    • The influence of iron loading and iron chelation on the proliferation and telomerase activity of human peripheral blood mononuclear cells
    • B. Bagherpour, M. Gharagozloo, and B. Moayedi The influence of iron loading and iron chelation on the proliferation and telomerase activity of human peripheral blood mononuclear cells Iran J Immunol 6 2009 33 39
    • (2009) Iran J Immunol , vol.6 , pp. 33-39
    • Bagherpour, B.1    Gharagozloo, M.2    Moayedi, B.3
  • 7
    • 57049090021 scopus 로고    scopus 로고
    • Double-faced cell-mediated immunity in beta-thalassemia major: Stimulated phenotype versus suppressed activity
    • M. Gharagozloo, M. Karimi, and Z. Amirghofran Double-faced cell-mediated immunity in beta-thalassemia major: stimulated phenotype versus suppressed activity Ann Hematol 88 2009 21 27
    • (2009) Ann Hematol , vol.88 , pp. 21-27
    • Gharagozloo, M.1    Karimi, M.2    Amirghofran, Z.3
  • 8
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol Rev 52 2000 673 751
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, Jr.E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 9
    • 0036827673 scopus 로고    scopus 로고
    • Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity
    • DOI 10.1080/1071576021000016463
    • L. Mira, M.T. Fernandez, M. Santos, R. Rocha, M.H. Florencio, and K.R. Jennings Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity Free Radic Res 36 2002 1199 1208 (Pubitemid 35230240)
    • (2002) Free Radical Research , vol.36 , Issue.11 , pp. 1199-1208
    • Mira, L.1    Fernandez, M.T.2    Santos, M.3    Rocha, R.4    Florencio, M.H.5    Jennings, K.R.6
  • 10
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin - New and emerging applications in medicine
    • R. Gazak, D. Walterova, and V. Kren Silybin and silymarin - new and emerging applications in medicine Curr Med Chem 14 2007 315 338
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazak, R.1    Walterova, D.2    Kren, V.3
  • 11
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: From basic research to clinical practice
    • C. Loguercio, and D. Festi Silybin and the liver: from basic research to clinical practice World J Gastroenterol 17 2011 2288 2301
    • (2011) World J Gastroenterol , vol.17 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 12
    • 77957829520 scopus 로고    scopus 로고
    • The iron-chelating potential of silybin in patients with hereditary haemochromatosis
    • C. Hutchinson, A. Bomford, and C.A. Geissler The iron-chelating potential of silybin in patients with hereditary haemochromatosis Eur J Clin Nutr 64 2010 1239 1241
    • (2010) Eur J Clin Nutr , vol.64 , pp. 1239-1241
    • Hutchinson, C.1    Bomford, A.2    Geissler, C.A.3
  • 13
    • 54549086511 scopus 로고    scopus 로고
    • Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C
    • J.M. Bares, J. Berger, J.E. Nelson, D.J. Messner, S. Schildt, and L.J. Standish Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C J Clin Gastroenterol 42 8 2008 Sep 937 944
    • (2008) J Clin Gastroenterol , vol.42 , Issue.8 , pp. 937-944
    • Bares, J.M.1    Berger, J.2    Nelson, J.E.3    Messner, D.J.4    Schildt, S.5    Standish, L.J.6
  • 14
    • 67149141758 scopus 로고    scopus 로고
    • Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: A randomized double-blind clinical trial
    • M. Gharagozloo, B. Moayedi, M. Zakerinia, M. Hamidi, M. Karimi, and M. Maracy Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial Fundam Clin Pharmacol 23 2009 359 365
    • (2009) Fundam Clin Pharmacol , vol.23 , pp. 359-365
    • Gharagozloo, M.1    Moayedi, B.2    Zakerinia, M.3    Hamidi, M.4    Karimi, M.5    Maracy, M.6
  • 15
    • 84873991943 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine
    • B. Moayedi, M. Gharagozloo, N. Esmaeil, M.R. Maracy, H. Hoorfar, and M. Jalaeikar A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine Eur J Haematol 90 2013 202 209
    • (2013) Eur J Haematol , vol.90 , pp. 202-209
    • Moayedi, B.1    Gharagozloo, M.2    Esmaeil, N.3    Maracy, M.R.4    Hoorfar, H.5    Jalaeikar, M.6
  • 18
    • 33744980639 scopus 로고    scopus 로고
    • Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from β-thalassemia major patients
    • DOI 10.1016/j.intimp.2006.04.004, PII S1567576906001214
    • F. Alidoost, M. Gharagozloo, B. Bagherpour, A. Jafarian, S.E. Sajjadi, and H. Hourfar Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from beta-thalassemia major patients Int Immunopharmacol 6 2006 1305 1310 (Pubitemid 43868191)
    • (2006) International Immunopharmacology , vol.6 , Issue.8 , pp. 1305-1310
    • Alidoost, F.1    Gharagozloo, M.2    Bagherpour, B.3    Jafarian, A.4    Sajjadi, S.E.5    Hourfar, H.6    Moayedi, B.7
  • 19
    • 0025251751 scopus 로고
    • Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers
    • I. Lang, K. Nekam, G. Deak, G. Muzes, R. Gonzales-Cabello, and P. Gergely Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers Ital J Gastroenterol 22 1990 283 287
    • (1990) Ital J Gastroenterol , vol.22 , pp. 283-287
    • Lang, I.1    Nekam, K.2    Deak, G.3    Muzes, G.4    Gonzales-Cabello, R.5    Gergely, P.6
  • 20
  • 23
    • 0034303318 scopus 로고    scopus 로고
    • Effects of iron overload on the immune system
    • E.M. Walker Jr., and S.M. Walker Effects of iron overload on the immune system Ann Clin Lab Sci 30 2000 354.65
    • (2000) Ann Clin Lab Sci , vol.30 , pp. 35465
    • Walker, Jr.E.M.1    Walker, S.M.2
  • 24
    • 84855833416 scopus 로고    scopus 로고
    • Silymarin in the prevention and treatment of liver diseases and primary liver cancer
    • J. Féher, and G. Lengyel Silymarin in the prevention and treatment of liver diseases and primary liver cancer Curr Pharm Biotechnol 13 2012 210 217
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 210-217
    • Féher, J.1    Lengyel, G.2
  • 25
    • 35748931783 scopus 로고    scopus 로고
    • The roles of innate immune cells in liver injury and regeneration
    • Z. Dong, H. Wei, R. Sun, and Z. Tian The roles of innate immune cells in liver injury and regeneration Cell Mol Immunol 4 2007 241 252
    • (2007) Cell Mol Immunol , vol.4 , pp. 241-252
    • Dong, Z.1    Wei, H.2    Sun, R.3    Tian, Z.4
  • 27
    • 77950626596 scopus 로고    scopus 로고
    • Silymarin suppress CD4 + T cell activation and proliferation: Effects on NF-kappaB activity and IL-2 production
    • M. Gharagozloo, E. Velardi, S. Bruscoli, M. Agostini, M. Di Sante, and V. Donato Silymarin suppress CD4 + T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production Pharmacol Res 61 2010 405 409
    • (2010) Pharmacol Res , vol.61 , pp. 405-409
    • Gharagozloo, M.1    Velardi, E.2    Bruscoli, S.3    Agostini, M.4    Di Sante, M.5    Donato, V.6
  • 28
    • 84875063931 scopus 로고    scopus 로고
    • Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: Therapeutic implications for autoimmune diseases
    • M. Gharagozloo, E.N. Javid, A. Rezaei, and K. Mousavizadeh Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases Basic Clin Pharmacol Toxicol 112 2013 251 256
    • (2013) Basic Clin Pharmacol Toxicol , vol.112 , pp. 251-256
    • Gharagozloo, M.1    Javid, E.N.2    Rezaei, A.3    Mousavizadeh, K.4
  • 31
    • 34250708509 scopus 로고    scopus 로고
    • Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells
    • DOI 10.1007/s00432-007-0197-x
    • M. Gharagozloo, and Z. Amirghofran Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells J Cancer Res Clin Oncol 133 2007 525 532 (Pubitemid 46955680)
    • (2007) Journal of Cancer Research and Clinical Oncology , vol.133 , Issue.8 , pp. 525-532
    • Gharagozloo, M.1    Amirghofran, Z.2
  • 33
    • 0021259518 scopus 로고
    • Deferoxamine: A reversible S-phase inhibitor of human lymphocyte proliferation
    • H.M. Lederman, A. Cohen, J.W. Lee, M.H. Freedman, and E.W. Gelfand Deferoxamine: a reversible S-phase inhibitor of human lymphocyte proliferation Blood 64 1984 748 753 (Pubitemid 14073498)
    • (1984) Blood , vol.64 , Issue.3 , pp. 748-753
    • Lederman, H.M.1    Cohen, A.2    Lee, J.W.W.3
  • 34
    • 0022654262 scopus 로고
    • Desferoxamine blocks IL 2 receptor expression on human T lymphocytes
    • P. Carotenuto, O. Pontesilli, J.C. Cambier, and A.R. Hayward Desferoxamine blocks IL 2 receptor expression on human T lymphocytes J Immunol 136 1986 2342 2347 (Pubitemid 16136805)
    • (1986) Journal of Immunology , vol.136 , Issue.7 , pp. 2342-2347
    • Carotenuto, P.1    Pontesilli, O.2    Cambier, J.C.3    Hayward, A.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.