Trolox mitigates fibrosis in a bile duct ligation model

Fundamental and Clinical Pharmacology

Volumn 27, Issue 3, 2013, Pages 308-318

  Galicia Moreno, Marina ^a   Favari, Liliana ^a   Muriel, Pablo ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Cirrhosis; Cytokines; Fibrosis; Oxidative stress; TGF 1

Indexed keywords

ALANINE AMINOTRANSFERASE; CATALASE; COLLAGEN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROXYPROLINE; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILE DUCT LIGATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; IMMUNOMODULATION; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; BILE DUCTS; BLOTTING, WESTERN; CHROMANS; COLLAGEN; GLUTATHIONE; HYDROXYPROLINE; INTERLEUKIN-10; INTERLEUKIN-6; LIPID PEROXIDATION; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84877806014     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.01020.x     Document Type: Article

References (70)

1. Friedman S.L.The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. New. Engl. J. Med. (1993) 328 1828-1835.
2. Muriel P.Some experimental models of liver damage, in: Sahu S. (Ed.), Hepatotoxicity: from genomics to in vitro and in vivo models, Wiley and Sons Ltd, West Sussex, UK, 2007, pp. 371-389.
3. Svegliati B.G., D′Ambrosio L., Ferretti G. et al.Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology (1998) 27 720-726.
4. Geerts A., De Bleser P., Hautekeete M.L., Niki T., Wisse E.Fat-storing (ITO) cell biology, in: Arias I., Popper H., Fausto N., Jacoby W.B., Schafritz D.A. (Eds), The liver: biology and pathobiology, Raven Press Ltd, New York, NY, USA, 1994, pp. 819-838.
5. Gressner A.M., Weiskirchen R., Breitkopf K., Dooley S.Roles of TGF-β in hepatic fibrosis. Front. Biosci. (2002) 7 793-807.
6. Friedman S.L.Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. (2000) 275 2247-2250.
7. Burt A.D.Cellular and molecular aspects of hepatic fibrosis. J. Pathol. (1993) 170 105-114.
8. Gressner A.M.Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J. Hepatol. (1995) 22 28-36.
9. Pinzani M.Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte. J. Hepatol. (1995) 22 700-706.
10. Yata Y., Gotwals P., Koteliansky V., Rockey D.C.Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: implications for antifibrotic therapy. Hepatology (2002) 35 1022-1033.
11. Nakamura T., Sakata R., Ueno T., Sata M., Ueno H.Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology (2000) 32 247-255.
12. George J., Roulot D., Koteliansky V.E., Bissell D.M.In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type III receptor: a potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. (1999) 96 12719-12724.
13. Arias M., Lahme B., Van de Leur E., Gressner A.M., Weiskirchen R.Adenoviral delivery of an antisense RNA complementary to the 3′coding sequence of transforming factor beta 1 inhibits fibrogenic activities of hepatic stellate cells. Cell Growth Differ. (2002) 13 265-273.
14. Arias M., Sauer-Lehnen S., Treptau J. et al.Adenoviral expression of a transforming growth factor- beta 1 antisense mRNA is effective in preventing liver fibrosis inn bile-duct ligated rats. Gastroenterol. (2003) 3 29-40.
15. Liu R.M., Gaston Pravia K.A.Oxidative stress and glutathione in TGF-β-mediated fibrogenesis. Free Radic. Biol. Med. (2010) 48 1-15.
16. Doba T., Burton G.W., Ingold K.U.Antioxidants and co-antioxidant activity of vitamin C: the effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim. Biophys. Acta. (1985) 835 298-303.
17. Barclay L.R.C., Locke S.J., MacNeil J.M.Autooxidation in micelles: synergism of vitamin C with lipid-soluble vitamin E and water-soluble Trolox. Can. J. Chem. (1985) 63 366-374.
18. Castle L., Perkins M.J.Inhibition kinetics of chain-breaking phenolic antioxidants in SDS micelles: evidence that intermicellar diffusion rates may be rate-limiting for hydrophobic inhibitors such as alpha-tocopherol. J. Am. Chem. Soc. (1986) 108 6381-6382.
19. Casini A.F., Pompella A., Comporti M.Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis. Am. J. Pathol. (1985) 118 225-237.
20. Wu T.W., Hashimoto N., Au J.X., Wu J., Mickle D.A., Carey D.Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury. Hepatology (1991) 13 575-580.
21. Galicia-Moreno M., Rodríguez-Rivera A., Reyes-Gordillo K. et al.Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis. Basic. Clin. Pharmacol. Toxicol. (2008) 103 476-481.
22. Baron V., Muriel P.Role of glutathione, lipid peroxidation and antioxidants on acute bile-duct obstruction in the rat. Biochim. Biophys. Acta (1999) 1472 173-180.
23. Reitman S., Frankel S.A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. (1957) 28 56-63.
24. Prockop D.J., Udenfriend S.A specific method for the analysis of hydroxyproline in tissues and urine. Anal. Biochem. (1960) 1 228-239.
25. Muriel P., Deheza R.Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorate by metadoxine. Liver Int. (2003) 23 262-268.
26. Garcia Tovar C.G., Perez A., Luna J. et al.Biochemical and histochemical analysis of 71 KDa dystrophin isoform (Dp71f) in rat brain. Acta Histochem. (2001) 103 209-224.
27. Okawa H., Ohmishi N., Yagi K.Assay for lipid peroxides in animal tissues by the thiobarbituric acid reaction. Anal. Biochem. (1979) 95 351-358.
28. Bradford M.M.A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. (1976) 72 248-254.
29. Hissin P.J., Hilf R.A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. (1976) 74 214-226.
30. Cohen G., Dembiec D., Marcus J.Measurement of catalase activity in tissue extracts. Biochemistry (1970) 34 30-38.
31. Lawrence R.A., Burk R.Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. (1976) 71 952-958.
32. Plaa G.L., Hewitt W.R.Detection and evaluation of chemically induced liver injury, in: Hayes W. (Ed.), Principles and methods of toxicology, Raven Press, New York, NY, USA, 1982, pp. 407-445.
33. Gaedeke J., Noble A.N., Border A.W.Curcumin blocks multiple sites of the TGF-β signaling cascade in renal cells. Kidney Int. (2004) 66 112-120.
34. Tuncer I., Ozbek H., Topal C., Uygan I.The serum levels of IL-1β, IL-6, IL-8 and TNF-α in nonalcoholic fatty liver. Turk. J. Med. Sci. (2003) 33 381-386.
35. Moore K.W., De Waal Malefyt R., Coffman R.L., O′Garra A.Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. (2001) 19 683-765.
36. Naguib Y.M.A fluorometric method for measurement of peroxyl radical scavenging activities of lipophilic antioxidants. Anal. Biochem. (1998) 265 290-298.
37. Barclay L.R., Artz J.D., Mowat J.J.Partitioning and antioxidant action of water-soluble antioxidant, trolox, between the aqueous and lipid phases of phosphatidylcholine membranes: 14C tracer and products studies. Biochim. Biophys. Acta (1995) 1237 77-85.
38. Bomzon A., Holt S., Moore K.Bile acids, oxidative stress and renal function in biliary obstruction. Semin. Nephrol. (1997) 17 549-562.
39. Sokol R.J., McKim J.M., Goff M.C. et al.Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology (1998) 114 164-174.
40. Sokol R.J., Devereaux M.W., Khandwala R.Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated rat. Pediatr. Res. (1998) 44 397-401.
41. Tsai L.Y., Lee K.T., Liu T.Z.Evidence for accelerated generation of hydroxyl radicals in experimental obstructive jaundice of rats. Free Radic. Biol. Med. (1998) 24 732-737.
42. Lopez P.M., Finana I.T., De Agueda M.C. et al.Protective effective of MEL against oxidative stress induced by ligature of extra-hepatic biliary duct in rats: comparison with the effect of S-adenosyl-L-methionine. J. Pineal Res. (2000) 28 143-149.
43. Yerushalmi B., Dahl R., Devereaux M.W., Gumpricht E., Sokol R.J.Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology (2001) 33 616-626.
44. Woudenberg Vrenken T.E., Buist Homan M., Conde de la Rosa L., Nico Faber K., Moshage H.Anti-oxidants do not prevent bile acid- induced cell death in rat hepatocytes. Liver Int. (2010) 30 1511-1521.
45. Sánchez-Patán F., Anchuelo R., Corcuera M.T. et al.Biliary fibrosis in microsurgical extrahepatic cholestasis in the rat. Microsurgery (2008) 28 361-366.
46. Aub C., Moal F., Oberti F. et al.Diagnosis and measurement of liver fibrosis by MRI in bile duct ligated rats. Dig. Dis. Sci. (2007) 52 2601-2609.
47. Rockey D.Hepatic fibrosis, stellate cells, and portal hypertension. Clin. Liver Dis. (2006) 10 459-479.
48. Gressner O.A., Weiskirchen R., Gressner A.M.Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options. Comp. Hepatol. (2007) 6 7.
49. Proell V., Carmona Cuenca I., Murillo M.M., Huber H., Fabregat I., Mikulits W.TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp. Hepatol. (2007) 6 1.
50. Parola M., Robino G.Oxidative stress-related molecules and liver fibrosis. J. Hepatol. (2001) 35 297-306.
51. Friedman S.L.Cytokines and fibrogenesis. Semin. Liver Dis. (1999) 19 129-140.
52. Thannickal V.J., Day R.M., Klinz S.G., Bastien M.C., Larios J.M., Fanburg B.L.Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-beta 1. FASEB J. (2000) 14 1741-1748.
53. Thannickal V.J., Fanburg B.L.Activation of an H2O2-generating NADH oxidase in human lung fibroblast by transforming growth factor beta 1. J. Biol. Chem. (1995) 270 30334-30338.
54. Thannickal V.J., Hassoun P.M., White A.C., Fanburg B.L.Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells. Am. J. Physiol. (1993) 265 L622-L626.
55. Herrera B., Murillo M.M., Alvarez Barrientos A., Beltran J., Fernandez M., Fabregat I.Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes. Free Radic. Biol. Med. (2004) 36 16-24.
56. Albright C.D., Salganik R.I., Craciunescu C.N., Mar M.H., Zeisel S.H.Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta 1 in immortalized rat hepatocytes. J. Cell. Biochem. (2003) 89 254-261.
57. Muriel P.Cytokines in liver diseases, in: Sahu S. (Ed.), Hepatotoxicity: from genomics to in vitro and in vivo models, Jonh Wiley and Sons LTD, West Sussex, UK, 2007, pp. 371-389.
58. Rees R.C.Cytokines as biological response modifiers. J. Clin. Pathol. (1992) 45 93-98.
59. Enayati P., Brennan M.F., Fong Y.Systemic and liver cytokine activation. Arch. Surg. (1994) 129 1159-1164.
60. Andus T., Holstege A.Cytokines and the liver in health and disease. Effects on liver metabolism and fibrogenesis. Acta Gastroenterol. Belg. (1994) LVII 236-244.
61. McClain C., Hill D., Schmidt J., Diehl A.M.Cytokines and the alcoholic liver disease. Semin. Liver Dis. (1993) 13 170-182.
62. Tilg H.The role of cytokines in the pathophysiology of chronic liver diseases. Int. J. Clin. Lab. Res. (1993) 23 179-185.
63. Rosser B.G., Gores G.J.Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology (1995) 108 252-275.
64. Marucci L., Svegliati Baroni G., Mancini R., Benedetti A., Jezequel A.M., Orlandi F.Cell proliferation following extrahepatic biliary obstruction. J. Hepatol. (1993) 17 163-169.
65. Martinez O.M., Villanueva J.C., Greshwin M.E., Krams S.M.Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology (1993) 21 113-119.
66. Nelson D.R., Lauwers G.Y., Lau J.Y., Davis G.L.Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon non-responders. Gastroenterology (2000) 118 655-660.
67. Ramadory G., Saile B.Portal tract fibrogenesis in the liver. Lab. Invest. (2004) 84 153-159.
68. Ko K.M., Yick P.K., Poon M.K.T., Ip S.P.Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids. Mol. Cell. Biochem. (1994) 141 65-70.
69. Diaz Z., Colombo M., Mann K.K. et al.Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines. Blood (2005) 105 1237-1245.
70. Bast A., Haenen G.R.M.M.The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. (2002) 11 251-258.