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Volumn 27, Issue 3, 2013, Pages 271-278

Efficacy of tadalafil in chronic hypobaric hypoxia-induced pulmonary hypertension: Possible mechanisms

Author keywords

Antioxidant; Hypoxia; Inflammation; Pulmonary hypertension; Tadalafil; Tempol

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TADALAFIL; TEMPOL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84877799264     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.01013.x     Document Type: Article
Times cited : (16)

References (34)
  • 2
    • 0036773104 scopus 로고    scopus 로고
    • The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?
    • Natalie H., McLoughlin P.The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?J. Anat. (2002) 201 335-348.
    • (2002) J. Anat. , vol.201 , pp. 335-348
    • Natalie, H.1    McLoughlin, P.2
  • 3
    • 77955886101 scopus 로고    scopus 로고
    • The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension
    • Falk J.A., Philip K.J., Schwarz E.R.The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension. Vasc. Health Risk Manag. (2010) 6 273-280.
    • (2010) Vasc. Health Risk Manag. , vol.6 , pp. 273-280
    • Falk, J.A.1    Philip, K.J.2    Schwarz, E.R.3
  • 5
    • 0037150158 scopus 로고    scopus 로고
    • Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide
    • Michelakis E.D., Tymchak W., Lien D., Webster L., Hashimoto K., Archer S.Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation (2002) 105 2398-2403.
    • (2002) Circulation , vol.105 , pp. 2398-2403
    • Michelakis, E.D.1    Tymchak, W.2    Lien, D.3    Webster, L.4    Hashimoto, K.5    Archer, S.6
  • 6
    • 78651519019 scopus 로고    scopus 로고
    • Attenuation of Doxorubicin-induced cardiotoxicity by tadalafil: a long acting phosphodiesterase-5 inhibitor
    • Koka S., Kukreja R.C.Attenuation of Doxorubicin-induced cardiotoxicity by tadalafil: a long acting phosphodiesterase-5 inhibitor. Mol. Cell. Pharmacol. (2010) 2 173-178.
    • (2010) Mol. Cell. Pharmacol. , vol.2 , pp. 173-178
    • Koka, S.1    Kukreja, R.C.2
  • 7
    • 72849113368 scopus 로고    scopus 로고
    • Tadalafil for treatment of pulmonary arterial hypertension
    • Erika B.R.Tadalafil for treatment of pulmonary arterial hypertension. Expert Opin. Pharmacother. (2010) 11 127-132.
    • (2010) Expert Opin. Pharmacother. , vol.11 , pp. 127-132
    • Erika, B.R.1
  • 8
    • 77956233231 scopus 로고    scopus 로고
    • Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect
    • Koka S., Das A., Zhu S.G., Durrant D., Xi L., Kukreja R.C.Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect. J. Pharmacol. Exp. Ther. (2010) 334 1023-1030.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 1023-1030
    • Koka, S.1    Das, A.2    Zhu, S.G.3    Durrant, D.4    Xi, L.5    Kukreja, R.C.6
  • 9
    • 78049474906 scopus 로고    scopus 로고
    • Protective effect of tadalafil on ischemia/reperfusion injury of rat ovary
    • Arikan D.C., Bakan V., Kurutas E.B., Sayar H., Coskun A.Protective effect of tadalafil on ischemia/reperfusion injury of rat ovary. J.Ped. Surg. (2010) 45 2203-2209.
    • (2010) J.Ped. Surg. , vol.45 , pp. 2203-2209
    • Arikan, D.C.1    Bakan, V.2    Kurutas, E.B.3    Sayar, H.4    Coskun, A.5
  • 10
    • 77949656033 scopus 로고    scopus 로고
    • Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study
    • Verit A., Savas M., Ciftci H., Aksoy N., Taskin A., Topal U.Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study. Int. J. Impot. Res. (2010) 22 115-119.
    • (2010) Int. J. Impot. Res. , vol.22 , pp. 115-119
    • Verit, A.1    Savas, M.2    Ciftci, H.3    Aksoy, N.4    Taskin, A.5    Topal, U.6
  • 11
    • 29144470350 scopus 로고    scopus 로고
    • Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression
    • Tsai B.M., Turrentine M.W., Sheridan B.C. et al.Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression. Ann. Thorac. Surg. (2006) 81 272-278.
    • (2006) Ann. Thorac. Surg. , vol.81 , pp. 272-278
    • Tsai, B.M.1    Turrentine, M.W.2    Sheridan, B.C.3
  • 12
    • 0034661990 scopus 로고    scopus 로고
    • Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin
    • Chandel N.S., Trzyna W.C., McClintock D.S., Schumacker P.T.Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. (2000) 165 1013-1021.
    • (2000) J. Immunol. , vol.165 , pp. 1013-1021
    • Chandel, N.S.1    Trzyna, W.C.2    McClintock, D.S.3    Schumacker, P.T.4
  • 13
    • 1242318713 scopus 로고    scopus 로고
    • The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats
    • Elmedal B., deDam M.Y., Mulvany M.J., Siminsen U.The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats. Br. J. Pharmacol. (2004) 141 105-113.
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 105-113
    • Elmedal, B.1    deDam, M.Y.2    Mulvany, M.J.3    Siminsen, U.4
  • 14
    • 0347260024 scopus 로고    scopus 로고
    • Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia
    • Thomas B.H., Wanstall J.C.Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia. Eur. J. Pharmacol. (2003) 477 153-161.
    • (2003) Eur. J. Pharmacol. , vol.477 , pp. 153-161
    • Thomas, B.H.1    Wanstall, J.C.2
  • 15
    • 0019475281 scopus 로고
    • Cytosolic factors that affect microsomal lipid peroxidation in lung and liver
    • Wright J.R., Colby H.D., Miles P.R.Cytosolic factors that affect microsomal lipid peroxidation in lung and liver. Arch. Biochem. Biophys. (1981) 206 296-304.
    • (1981) Arch. Biochem. Biophys. , vol.206 , pp. 296-304
    • Wright, J.R.1    Colby, H.D.2    Miles, P.R.3
  • 16
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis: protective role of glutathione an evidence for 3,4 bromo benzenoxide as the hepatotoxic intermediate
    • Jollow D., Mitchell L., Zampaglione N., Gillete J.Bromobenzene induced liver necrosis: protective role of glutathione an evidence for 3, 4 bromo benzenoxide as the hepatotoxic intermediate. Pharmacology (1974) 11 151-169.
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.1    Mitchell, L.2    Zampaglione, N.3    Gillete, J.4
  • 17
    • 0033795729 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodelling: a model for what human disease?
    • Voelkel N.F., Rubin M.T.Hypoxia-induced pulmonary vascular remodelling: a model for what human disease?J. Clin. Invest. (2000) 106 733-738.
    • (2000) J. Clin. Invest. , vol.106 , pp. 733-738
    • Voelkel, N.F.1    Rubin, M.T.2
  • 18
    • 14644405546 scopus 로고    scopus 로고
    • Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats
    • Andersen C.U., Mulvany M.J., Simonsen U.Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. Eur. J. Pharmacol. (2005) 510 87-96.
    • (2005) Eur. J. Pharmacol. , vol.510 , pp. 87-96
    • Andersen, C.U.1    Mulvany, M.J.2    Simonsen, U.3
  • 19
    • 40949157993 scopus 로고    scopus 로고
    • Sustained benefit of tadalafil in patients with pulmonary arterial hypertension with prior response to sildenafil: a case series of 12 patients
    • Tay E.L., Geok-Mui M.K., Poh-Hoon M.C., Yip J.Sustained benefit of tadalafil in patients with pulmonary arterial hypertension with prior response to sildenafil: a case series of 12 patients. Int. J. Cardiol. (2008) 125 416-417.
    • (2008) Int. J. Cardiol. , vol.125 , pp. 416-417
    • Tay, E.L.1    Geok-Mui, M.K.2    Poh-Hoon, M.C.3    Yip, J.4
  • 20
    • 33644773545 scopus 로고    scopus 로고
    • Tadalafil improves quality of life and exercise tolerance in idiopathic pulmonary arterial hypertension
    • Affuso F., Palmieri E.A., Di Conza P., Guardasole V., Fazio S.Tadalafil improves quality of life and exercise tolerance in idiopathic pulmonary arterial hypertension. Int. J. Cardiol. (2006) 108 429-431.
    • (2006) Int. J. Cardiol. , vol.108 , pp. 429-431
    • Affuso, F.1    Palmieri, E.A.2    Di Conza, P.3    Guardasole, V.4    Fazio, S.5
  • 21
    • 0035933388 scopus 로고    scopus 로고
    • Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing
    • Waypa G.B., Chandel N.S., Schumacker P.T.Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ. Res. (2001) 88 1259-1266.
    • (2001) Circ. Res. , vol.88 , pp. 1259-1266
    • Waypa, G.B.1    Chandel, N.S.2    Schumacker, P.T.3
  • 22
    • 0035883591 scopus 로고    scopus 로고
    • Increased lipid peroxidation in patients with pulmonary hypertension
    • Cracowski J.L., Cracowski C., Bessard G. et al.Increased lipid peroxidation in patients with pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2001) 164 1038-1042.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164 , pp. 1038-1042
    • Cracowski, J.L.1    Cracowski, C.2    Bessard, G.3
  • 23
    • 0024354960 scopus 로고
    • Effects of dimethylthiourea on chronic hypoxia-induced pulmonary arterial remodelling and ventricular hypertrophy in rats
    • Langleben D., Fox R.B., Jones R.C., Reid L.M.Effects of dimethylthiourea on chronic hypoxia-induced pulmonary arterial remodelling and ventricular hypertrophy in rats. Clin. Invest. Med. (1989) 12 235-240.
    • (1989) Clin. Invest. Med. , vol.12 , pp. 235-240
    • Langleben, D.1    Fox, R.B.2    Jones, R.C.3    Reid, L.M.4
  • 24
    • 0242579616 scopus 로고    scopus 로고
    • Overview of phosphodiesterase 5 inhibition in erectile dysfunction
    • Rosen R.C., Kostis J.B.Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am. J. Cardiol. (2003) 92 9M-18M.
    • (2003) Am. J. Cardiol. , vol.92
    • Rosen, R.C.1    Kostis, J.B.2
  • 25
    • 79951841720 scopus 로고    scopus 로고
    • Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction
    • Savas M., Yeni E., Verit A. et al.Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction. Clinics (2010) 65 1311-1314.
    • (2010) Clinics , vol.65 , pp. 1311-1314
    • Savas, M.1    Yeni, E.2    Verit, A.3
  • 26
    • 61549104663 scopus 로고    scopus 로고
    • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    • Savale L., Tu L., Rideau D. et al.Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Resp. Res. (2009) 10 6.
    • (2009) Resp. Res. , vol.10 , pp. 6
    • Savale, L.1    Tu, L.2    Rideau, D.3
  • 28
    • 0345404428 scopus 로고    scopus 로고
    • Endotoxin differentially impairs receptor-mediated relaxation in rat isolated pulmonary and thoracic aortic vessels
    • McIntyre R.C., Pulido E.J. Jr, Sheridan B.Endotoxin differentially impairs receptor-mediated relaxation in rat isolated pulmonary and thoracic aortic vessels. J. Trauma (1998) 45 862-867.
    • (1998) J. Trauma , vol.45 , pp. 862-867
    • McIntyre, R.C.1    Pulido Jr., E.J.2    Sheridan, B.3
  • 29
    • 0036550197 scopus 로고    scopus 로고
    • Acute hypoxemia in humans enhances the neutrophil inflammatory response
    • Tamura D.Y., Moore E.E., Partrick D.A.Acute hypoxemia in humans enhances the neutrophil inflammatory response. Shock (2002) 17 269-273.
    • (2002) Shock , vol.17 , pp. 269-273
    • Tamura, D.Y.1    Moore, E.E.2    Partrick, D.A.3
  • 30
    • 0027414192 scopus 로고
    • A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release
    • Kisala J.M., Ayala A., Stephan R.N., Chuadry I.H.A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release. Am. J. Physiol. (1993) 264 R610-R614.
    • (1993) Am. J. Physiol. , vol.264
    • Kisala, J.M.1    Ayala, A.2    Stephan, R.N.3    Chuadry, I.H.4
  • 31
    • 0027081351 scopus 로고
    • TNF-alpha augments pulmonary vasoconstriction via the inhibition of nitrovasodilator activity
    • Johnson A., Ferro T.J.TNF-alpha augments pulmonary vasoconstriction via the inhibition of nitrovasodilator activity. J. Appl. Physiol. (1992) 73 2483-2492.
    • (1992) J. Appl. Physiol. , vol.73 , pp. 2483-2492
    • Johnson, A.1    Ferro, T.J.2
  • 32
    • 0034991801 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction increases during endotoxemia in the perfused rat lung
    • Castaneda J., Isusi A., Tamayo L.Hypoxic pulmonary vasoconstriction increases during endotoxemia in the perfused rat lung. J. Trauma (2001) 50 882-886.
    • (2001) J. Trauma , vol.50 , pp. 882-886
    • Castaneda, J.1    Isusi, A.2    Tamayo, L.3
  • 33
  • 34
    • 0032126807 scopus 로고    scopus 로고
    • Pulmonary hypertension and inflammation
    • Tuder R.M., Voelkel N.F.Pulmonary hypertension and inflammation. J. Lab. Clin. Med. (1998) 132 16-24.
    • (1998) J. Lab. Clin. Med. , vol.132 , pp. 16-24
    • Tuder, R.M.1    Voelkel, N.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.