The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats

British Journal of Pharmacology

Volumn 141, Issue 1, 2004, Pages 105-113

  Elmedal, Britt ^a   De Dam, Mette Y ^a   Mulvany, Michael John ^a   Simonsen, Ulf ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Chronic hypoxic pulmonary hypertension; Distal resistance pulmonary arteries; Molsidomine; Proximal pulmonary arteries; Tempol

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; LINSIDOMINE; MOLSIDOMINE; NITRIC OXIDE DONOR; POTASSIUM; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE CONTRACTION; HEMODYNAMIC MONITORING; HYPOBARISM; HYPOXIA; LUNG VASOCONSTRICTION; LUNG WEIGHT; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SYSTOLIC BLOOD PRESSURE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLCHOLINE; ADMINISTRATION, ORAL; ANIMALS; ANOXIA; BODY WEIGHT; CHRONIC DISEASE; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENDOTHELIN-1; FREE RADICAL SCAVENGERS; HEART RATE; HYPERTROPHY, RIGHT VENTRICULAR; MALE; MOLSIDOMINE; MUSCLE, SMOOTH, VASCULAR; ORGAN SIZE; PULMONARY ARTERY; RATS; RATS, WISTAR; SPIN LABELS; SUPEROXIDE DISMUTASE; VASOCONSTRICTION; VASODILATION; VENTRICULAR PRESSURE;

EID: 1242318713     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705580     Document Type: Article

References (44)

1. ARCHER, S. & RICH, S. (2000). Primary pulmonary hypertension: a vascular biology and translational research 'Work in progress'. Circulation, 102, 2781-2791.
2. BLUMBER, G.F.C., WOLF, K., SANDNER, P., LORENZ, C., RIEGGER, G.A. & PFEIFER, M. (2001). The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 280, L258-L263.
3. BUSSE, R., EDWARDS, G., FELETOU, M., FLEMING, I., VANHOUTTE, P.M. & WESTON, A.H. (2002). EDHF: bringing the concepts together. Trends Pharmacol. Sci., 23, 374-380.
4. CRACOWSKI, J.L., CRACOWSKI, C., BESSARD, G., PEPIN, J.L., BESSARD, J., SCHWEBEL, C., STANKE-LABESQUE, F. & PISON, C. (2001). Increased lipid peroxidation in patients with pulmonary hypertension. Am. J. Resp. Crit. Care Med., 164, 1038-1042.
5. DOBRIAN, A.D., SCHRIVER, S.D. & PREWITT, R.L. (2001). Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. Hypertension, 38, 361-366.
6. FEELISCH, M., OSTROWSKI, J. & NOACK, E. (1989). On the mechanism of NO release from sydnonimines. J. Cardiovasc. Pharmacol., 14 (Suppl 11), S13-S22.
7. FRANK, D.U., HORSTMAN, D.J., MORRIS, G.N., JOHNS, R.A. & RICH, G.F. (1998). Regulation of the endogenous NO pathway by prolonged inhaled NO in rats. J. Appl. Physiol., 85, 1070-1078.
8. HAMPL, V. & HERGET, J. (2000). Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiol. Rev., 80, 1337-1372.
9. HERGET, J., WILHELM, J., NOVOTNA, J., ECKHARDT, A., VYTASEK, R., MRAZKOVA, L. & OSTADAL, M. (2000). A possible role of the oxidant tissue injury in the development of hypoxic pulmonary hypertension. Physiol. Res., 49, 493-501.
10. HOAGLAND, K.M., MAIER, K.G. & ROMAN, R.J. (2003). Contributions of 20-HETE to the antihypertensive effects of tempol in Dahl salt-sensitive rats. Hypertension, 41, 697-702.
11. HOSHIKAWA, Y., ONO, S., SUZUKI, S., TANITA, T., CHIDA, M., SONG, C., NODA, M., TABATA, T., VOELKEL, N.F. & FUJIMURA, S. (2001). Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J. Appl. Physiol., 90, 1299-1306.
12. KATAYAMA, Y., HIGENBOTTAM, T.W., DIAZ DE ATAURI, M.J., CREMONA, G., AKAMINE, S., BARBERA, J.A. & RODRIGUEZ-ROISIN, R. (1997). Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension. Thorax, 52, 120-124.
13. KILLILEA, D.W., HESTER, R., BALCZON, R., BABAL, P. & GILLESPIE, M.N. (2000). Free radical production in hypoxic pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol., 279, L408-L412.
14. LAI, Y.L., WU, H.D. & CHEN, C.F. (1998). Antioxidants attenuate chronic hypoxic pulmonary hypertension. J. Cardiovasc. Pharmacol., 32, 714-720.
15. LAMPERT, E., TUO, N., FRANS, A. & LONSDORFER, J. (1991). Disappearance of molsidomine effects on pulmonary circulation of patients with chronic obstructive pulmonary disease after a three week treatment. Pathol. Biol. (Paris), 39, 29-33.
16. LANGLEBEN, D., FOX, R.B., JONES, R.C. & REID, L.M. (1989). Effects of dimethylthiourea on chronic hypoxia-induced pulmonary arterial remodelling and ventricular hypertrophy in rats. Clin. Invest. Med., 12, 235-240.
17. LEE, S.D., KIM, D.S., SHIM, T.S., LIM, C.M., KOH, Y., KIM, W.S. & KIM, W.D. (2001). Nitric oxide and molsidomine in the management of pulmonary hypertension in Takayasu's arteritis. Chest, 119, 302-307.
18. MATHEW, R., GLOSTER, E.S., SUNDARARAJAN, T., THOMPSON, C.I., ZEBALLOS, G.A. & GEWITZ, M.H. (1997). Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension. J. Appl. Physiol., 82, 1493-1498.
19. MEGSON, I.L. (2000). Nitric oxide donor drugs. Drugs Future, 25, 701-715.
20. MEYRICK, B. & REID, L. (1980). Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. A quantitative ultrastructural study. Lab. Invest., 42, 603-615.
21. MITANI, Y., MARUYAMA, K. & SAKURAI, M. (1997). Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation, 96, 689-697.
22. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 19-26.
23. MULVANY, M.J. & KORSGAARD, N. (1983). Correlations and otherwise between blood pressure, cardiac mass and resistance vessel characteristics in hypertensive, normotensive and hypertensive/normotensive hybrid rats. J. Hypertens., 1, 235-244.
24. NAKANISHI, I., TAJIMA, F., NAKAMURA, A., YAGURA, S.Y., OOKAWARA, T., YAMASHITA, H., SUZUKI, K., TANIGUCHI, N. & OHNO, H. (1995). Effects of hypobaric hypoxia on antioxidant enzymes in rats. J. Physiol., 489, 869-876.
25. NILSSON, U.A., OLSSON, L.I., CARLIN, G. & BYLUNDFELLENIUS, A.C. (1989). Inhibition of lipid-peroxidation by spin labels - relationships between structure and function. J. Biol. Chem., 264, 11131-11135.
26. OKA, M., HASUNUMA, K., WEBB, S.A., STELZNER, T.J., RODMAN, D.M. & MCMURTRY, I.F. (1993). EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am. J. Physiol., 264, L587-L597.
27. PRIEST, R.M., ROBERTSON, T.P., LEACH, R.M. & WARD, J.P. (1998). Membrane potential-dependent and -independent vasodilation in small pulmonary arteries from chronically hypoxic rats. J. Pharmacol. Exp. Ther., 285, 975-982.
28. RABINOVITCH, M. (2001). Pathobiology of pulmonary hypertension. Extracellular matrix. Clin. Chest. Med., 22, 433-449.
29. REID, L.M. (1979). The pulmonary circulation: remodeling in growth and disease. The 1978. J. Burns Amberson lecture. Am. Rev. Respir. Dis., 119, 531-546.
30. ROBERTS, J.D., CHICHE, J.D., WEIMANN, J., STEUDEL, W., ZAPOL, W.M. & BLOCH, K.D. (2000). Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups. Circ. Res., 87, 140-145.
31. ROBERTS JR, J.D., FINEMAN, J.R., MORIN III, F.C., SHAUL, P.W., RIMAR, S., SCHREIBER, M.D., POLIN, R.A., ZWASS, M.S., ZAYEK, M.M., GROSS, I., HEYMANN, M.A. & ZAPOL, W.M. (1997). Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N. Engl. J. Med., 336, 605-610.
32. ROBERTS, J.D., ROBERTS, C.T., JONES, R.C., ZAPOL, W.M. & BLOCH, K.D. (1995). Continuous nitric-oxide inhalation reduces pulmonary arterial structural-changes, right-ventricular hypertrophy, and growth-retardation in the hypoxic newborn rat. Circ. Res., 76, 215-222.
33. SCHNACKENBERG, C.G., WELCH, W.J. & WILCOX, C.S. (1998). Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension, 32, 59-64.
34. SHASTRI, S., GOPALAKRISHNAN, V., PODURI, R. & DI WANG, H. (2002). Tempol selectively attenuates angiotensin II evoked vasoconstrictor responses in spontaneously hypertensive rats. J. Hypertens., 20, 1381-1391.
35. SHAUL, P.W., WELLS, L.B. & HORNING, K.M. (1993). Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J. Cardiovasc. Pharmacol., 22, 819-827.
36. SHOKOJI, T., NISHIYAMA, A., FUJISAWA, Y., HITOMI, H., KIYOMOTO, H., TAKAHASHI, N., KIMURA, S., KOHNO, M. & ABE, Y. (2003). Renal sympathetic nerve responses to Tempol in spontaneously hypertensive rats. Hypertension, 41, 266-273.
37. + channels involved in the inhibition of acetylcholine-induced contractions in lamb coronary small arteries. Eur. J. Pharmacol., 329, 153-163.
38. SUTSCH, G., KIM, J.H., BRACHT, C. & KIOWSKI, W. (1997). Lack of cross-tolerance to short-term linsidomine in forearm resistance vessels and dorsal hand veins in subjects with nitroglycerin tolerance. Clin. Pharmacol. Therap., 62, 538-545.
39. WAYPA, G.B., CHANDEL, N.S. & SCHUMACKER, P.T. (2001). Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ. Res., 88, 1259-1266.
40. WEDGWOOD, S., DETTMAN, R.W. & BLACK, S.M. (2001). ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L1058-L1067.
41. WEINBERGER, B., LASKIN, D.L., HECK, D.E. & LASKIN, J.D. (2001). The toxicology of inhaled nitric oxide. Toxicol. Sci., 59, 5-16.
42. WIKLUND, L., MCGREGOR, C.G.A. & MILLER, V.M. (1996). Effects of prolonged exposure to oxygen-derived free radicals in canine pulmonary arteries. Am. J. Physiol. Heart Circ. Physiol., 39, H2184-H2190.
43. XU, H., FINK, G.D., CHEN, A., WATTS, S. & GALLIGAN, J.J. (2001). Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats. Am. J. Physiol. Heart Circ. Physiol., 281, H975-H980.
44. YU, M., MCANDREW, R.P., AL SAGHIR, R., MAIER, K.G., MEDHORA, M., ROMAN, R.J. & JACOBS, E.R. (2002). Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. J. Appl. Physiol., 93, 1391-1399.