Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro

European Journal of Pharmacology

Volumn 708, Issue 1-3, 2013, Pages 30-37

  Eibl, Joseph K ^a   Strasser, Bridget C ^a   Ross, Gregory M ^a  

^a LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Neurotrophin antagonist; Neurotrophin inhibition; NGF antagonist; PC12 cells; TrkA

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; N (2 HYDROXYETHYLAMINO) 3 NITRONAPHTHALIMIDE; NERVE GROWTH FACTOR; PD 90780; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE A; PYRAZOLOQUINAZOLINECARBOXYLIC ACID DERIVATIVE; RO 08 2750; UNCLASSIFIED DRUG; Y 1036;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EMBRYO; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; CELL DIFFERENTIATION; HETEROCYCLIC COMPOUNDS, 3-RING; MODELS, MOLECULAR; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; PTERIDINES; PYRAZOLES; QUINAZOLINES; RATS;

EID: 84877798408     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.03.029     Document Type: Article

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