Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1271-1276

  Owolabi, Joshua B ^a,d   Rizkalla, Geihan ^a   Tehim, Ashok ^a   Ross, Gregory M ^c   Riopelle, Richard J ^c   Kamboj, Rajender ^a   Ossipov, Michael ^b   Bian, Di ^b   Wegert, Sandara ^b   Porreca, Frank ^b   Lee, David K H ^a  

^a NPS Pharmaceutical Inc   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; N (2 HYDROXYETHYLAMINO) 3 NITRONAPHTHALIMIDE; NERVE GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR RECEPTOR ANTAGONIST; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; NERVE FIBER GROWTH; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANALGESICS; ANIMALS; CELLS, CULTURED; CHICK EMBRYO; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HEAT; HETEROCYCLIC COMPOUNDS, 3-RING; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SPINAL; MICE; MORPHINE; NERVE GROWTH FACTORS; NEURALGIA; NEURITES; NEURONS, AFFERENT; PAIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RADIOLIGAND ASSAY; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SPINAL CORD; SPINAL NERVES;

EID: 0033035408     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Aloe L, Turveri MA, Carcassi U and Levi-Montalcini R (1992) Nerve growth factor in synovial fluid of patients with chronic arthritis. Arthritis Rheumat 35:351-355.
2. Andreev NY, Dimitrieva N, Koltzenburg M and McMahon SB (1995) Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. Pain 63:109-115.
3. Averill S, McMahon SB, Clary DO, Reichardt LF and Priestly JV (1995) Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci 7:1484-1494.
4. Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55-63.
5. Chung K, Kim HJ, Na HS, Park MJ and Chung JM (1993) Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain. Neurosci Lett 162:85-88.
6. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pittsmeek S, Armanini MP, Ling LH, McMahon SB, Shelton DL, Levinson AD and Phillips HS (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011.
7. Diamond J, Coughlin M, Macintyre L, Holmes M and Visheau B (1987) Evidence that endogenous NGF is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats. Proc Natl Acad Sci USA 84:6596-6600.
8. Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441-462.
9. Donnerer J, Schuligoi R and Stein C (1992) Increased content and transport of substance-P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue - Evidence for a regulatory function of nerve growth factor in vivo. Neuroscience 49:693-698.
10. Dostaler SM, Ross GM, Myers SM, Weaver DF, Ananthanarayanan V and Riopelle RJ (1996) Characterization of a distinctive motif of the low molecular weight neurotrophin receptor that modulates NGF-mediated neurite outgrowth. Eur J Neurosci 8:870-879.
11. Greene LA and Tischler AS (1976) Establishment of a noradrenergic clonal cell line of rat pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2432.
12. Heumann R, Korshing S, Bandtlow C and Thoenen H (1987) Changes of nerve growth factor synthesis in non-neuronal cells in response to sciatic nerve transection. J Cell Biol 104:1623-1631.
13. Jaen JC, Laborde E, Busch RA, Caprathe BW, Sorenson RJ, Fergus J, Speigel K, Marks J, Dickerson MR and Davis RE (1995) Kynurenic acid derivatives inhibit the binding of nerve growth factor(NGF) to the low-affinity p75 receptor. J Med Chem 38:4439-4445.
14. Kaplan DR, Matin-Zanca D and Parada LF (1991) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature (Lond) 350:158-160.
15. Karlsten R, Post C, Hide I and Daly J (1991) The antinociceptive effect of intrathecally administered adenosine analogs in mice correlates with the affinity for the A1 adenosine receptor. Neurosci Lett 121:267-270.
16. Kim SH and Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-363.
17. Lewin GR and Mendell LM (1993) Nerve growth factor and nociception. Trends Neurosci 16:353-359.
18. Lewin GR, Rueff A and Mendell LM (1994) Peripheral and central mechanisms of NGF-induced hyperalgesia. Eur J Neurosci 6:1903-1912.
19. Lewin GR, Ritter AM and Mendell LM (1993) Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 13:2136-2148.
20. Max MB, Schafer SC, Culnane M, Dubner R and Gracely RH (1988) Association of pain relief with drug side effects in postherpetic neuralgia: A single-dose study of clonidine, codeine, ibuprofen, and placebo. Clin Pharmacol Ther 43:363-371.
21. May A, Gijsman HJ, Wallnofer A, Jones R, Diener HC and Ferrari MD (1996) Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks. Pain 67:375-378.
22. Mazzari S, Canella R, Petrelli L, Marcolongo G and Leon A (1996) N-(2-hydroxyethyl) hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-regulating mast cell activation. Eur J Pharmacol 300:227-236.
23. McMahon SB, Bennett DLH, Priestly JV and Shelton DL (1995) The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by trkA-IgG fusion molecule. Nat Med 1:774-780.
24. Murphy RA, Acheson A, Hodges R, Haskins J, Richard C, Reklow E, Chlumecky V, Barker P, Alderson RF and Lindsay RM (1993) Immunological relationships of NGF, BDNF, and NT-3: Recognition and functional inhibition by antibodies to NGF. J Neurosci 13:2853-2862.
25. Nichols ML, Bian D, Ossipov MH and Porreca F (1995) Modulation of opioid efficacy in a model of neuropathic pain in rats. Soc Neurosci Abstr 21:1172.
26. Pertovaara A, Kauppila T and Tukeva T (1990) Effect of medetomidine, an α2-adrenoceptor agonist, in various pain tests. Eur J Pharmacol 179:323-328
27. Petty BG, Cornblath DR, Adornato BT, Chaudhry V, Flexner C., Wachsman M, Sinicropi D, Burton LE and Perouka SJ (1994) The effect of systematically administered recombinant human nerve growth factor in healthy subjects. Ann Neurol 36:244-246.
28. 5]enkephalin after intracerebroventricular and intrathecal administration to mice. Life Sci 33:457-460.
29. Ramer MS and Bisby MA (1997) Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury. Pain 70:237-244.
30. Ramer MS, French GD, Fahnestock M and Bisby MA (1995) Strain differences in neuropathic pain behavior in mice following chronic constriction injury: Correlation with NGF production in injured nerve. See Neurosci Abstr 21:897.
31. Ritter AM, Lewin GR, Kremer NE and Mendell LM (1991) Requirement for nerve growth factor in the development of myelinated nociceptors in vivo. Nature (Lond) 350:500-502.
32. Ross GM, Shamovsky IL, Lawrance G, Sole M, Dostaler SM, Weaver DF and Riopelle RJ (1998) Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. Eur J Neurosci 10:890-898
33. Spiegel K, Agrafiotis D, Caprathe B, Davis RE, Dickerson MR, Ferfus JH, Hepburn TW, Marks JS, Van Dorf M, Wieland DM and Jaen JC (1995) PD 90780, a non peptide inhibitor of nerve growth factor's binding to the p75 receptor. Biochem Biophys Res Commun 217:488-494.
34. Suh HW, Song DK, Choi YS and Kim YH (1996) Effects of intrathecally injected histamine receptor antagonists on the antinociception induced by morphine, beta-endorphin, and U50,488H administered intrathecally in the mouse. Neuropeptides 30:485-490.
35. Sutter A, Riopelle RJ, Harris-Warrick RM and Shooter EM (1979) Nerve growth factor receptors. J Biol Chem 254:5972-5982.
36. Wiesenfeld-Hallin Z and Xu X-J (1996) The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance. Regul Pept 65:23-28.
37. Woolf CJ and Doubell TP (1994) The pathophysiology of chronic pain-increased sensitivity to low threshold Aβ-fiber inputs. Curr Opin Neurobiol 4:525-534.
38. Woolf CJ, Safiehgarabedian B, Ma QP, Crilly P and Winter J (1994) Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 62:327-331.
39. Xu X-J and Wiesenfeld-Hallin Z (1991) The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during antotomy after sciatic nerve section in rats. Pain 46:223-229.
40. Yaksh TL and Rudy TA (1976) Chronic catherization of the spinal subarachnoid space. Physiol Behav 17:1031-1036.