메뉴 건너뛰기




Volumn 13, Issue 3, 2013, Pages 358-367

Personalized medicine for glioblastoma: Current challenges and future opportunities

Author keywords

Glioblastoma; IDH1 mutation; MicroRNA; Personalized medicine; Tumor heterogeneity

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; 2 HYDROXYGLUTARIC ACID; ANAPLASTIC LYMPHOMA KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; ISOCITRATE DEHYDROGENASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA 107; MICRORNA 10B; MICRORNA 124; MICRORNA 16; MICRORNA 205; MICRORNA 21; MICRORNA 221; MICRORNA 222; MICRORNA 9; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; SCATTER FACTOR RECEPTOR; VASCULOTROPIN;

EID: 84877763967     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652413805076795     Document Type: Article
Times cited : (20)

References (82)
  • 2
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTCNCIC trial
    • Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTCNCIC trial. Lancet Oncol 2009; 10(5): 459-66.
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 3
    • 79951971900 scopus 로고    scopus 로고
    • Taming glioblastoma by targeting angiogenesis: 3 years later
    • Wong ET, Brem S. Taming glioblastoma by targeting angiogenesis: 3 years later. J Clin Oncol 2011; 29(2): 124-6.
    • (2011) J Clin Oncol , vol.29 , Issue.2 , pp. 124-126
    • Wong, E.T.1    Brem, S.2
  • 4
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
    • Norden AD, Young GS, Setayesh K, et al. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 2008; 70(10): 779-87.
    • (2008) Neurology , vol.70 , Issue.10 , pp. 779-787
    • Norden, A.D.1    Young, G.S.2    Setayesh, K.3
  • 5
    • 34547433234 scopus 로고    scopus 로고
    • Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations
    • Gao C, Furge K, Koeman J, et al. Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations. Proc Natl Acad Sci USA 2007; 104(21): 8995-9000.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.21 , pp. 8995-9000
    • Gao, C.1    Furge, K.2    Koeman, J.3
  • 6
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344(14): 1031-7.
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 7
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347(7): 472-80.
    • (2002) N Engl J Med , vol.347 , Issue.7 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 8
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350(21): 2129-39.
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 9
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2- overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2- overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999; 17(9): 2639-48.
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 10
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346(4): 235-42.
    • (2002) N Engl J Med , vol.346 , Issue.4 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 11
    • 84860790212 scopus 로고    scopus 로고
    • Molecular pathology in adult high-grade gliomas: From molecular diagnostics to target therapies
    • Masui K, Cloughesy TF, Mischel PS. Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol 2012; 38(3): 271-91.
    • (2012) Neuropathol Appl Neurobiol , vol.38 , Issue.3 , pp. 271-291
    • Masui, K.1    Cloughesy, T.F.2    Mischel, P.S.3
  • 12
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455(7216): 1061-8.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 13
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010; 17(1): 98-110.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 14
    • 77953811725 scopus 로고    scopus 로고
    • Cancer stem cells: Back to Darwin?
    • Greaves M. Cancer stem cells: back to Darwin? Semin Cancer Biol 2010; 20(2): 65-70.
    • (2010) Semin Cancer Biol , vol.20 , Issue.2 , pp. 65-70
    • Greaves, M.1
  • 15
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128(4): 683-92.
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 16
    • 34247540446 scopus 로고    scopus 로고
    • Epigenetics and microRNAs
    • Chuang JC, Jones PA. Epigenetics and microRNAs. Pediatr Res 2007; 61(5 Pt 2): 24R-9R.
    • (2007) Pediatr Res , vol.61 , Issue.5 PART 2
    • Chuang, J.C.1    Jones, P.A.2
  • 17
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6- methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi ME, Liu L, Herman JG, et al. Correlation of O6- methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 2008; 26(25): 4189-99.
    • (2008) J Clin Oncol , vol.26 , Issue.25 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3
  • 18
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012; 483(7390): 479-83.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 19
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010; 17(5): 510-22.
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 20
    • 51649111238 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma
    • Tepel M, Roerig P, Wolter M, et al. Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. Int J Cancer 2008; 123(9): 2080-6.
    • (2008) Int J Cancer , vol.123 , Issue.9 , pp. 2080-2086
    • Tepel, M.1    Roerig, P.2    Wolter, M.3
  • 21
    • 77951247981 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas
    • Gotze S, Wolter M, Reifenberger G, Muller O, Sievers S. Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. Int J Cancer 2010; 126(11): 2584-93.
    • (2010) Int J Cancer , vol.126 , Issue.11 , pp. 2584-2593
    • Gotze, S.1    Wolter, M.2    Reifenberger, G.3    Muller, O.4    Sievers, S.5
  • 22
    • 13444269098 scopus 로고    scopus 로고
    • Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas
    • Nakamura M, Ishida E, Shimada K, et al. Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas. Lab Invest 2005; 85(2): 165-75.
    • (2005) Lab Invest , vol.85 , Issue.2 , pp. 165-175
    • Nakamura, M.1    Ishida, E.2    Shimada, K.3
  • 23
    • 35148825960 scopus 로고    scopus 로고
    • DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas
    • Kunitz A, Wolter M, van den Boom J, et al. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas. Brain Pathol 2007; 17(4): 363-70.
    • (2007) Brain Pathol , vol.17 , Issue.4 , pp. 363-370
    • Kunitz, A.1    Wolter, M.2    van den Boom, J.3
  • 24
    • 0035133842 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RB1 gene in glioblastomas
    • Nakamura M, Yonekawa Y, Kleihues P, Ohgaki H. Promoter hypermethylation of the RB1 gene in glioblastomas. Lab Invest 2001; 81(1): 77-82.
    • (2001) Lab Invest , vol.81 , Issue.1 , pp. 77-82
    • Nakamura, M.1    Yonekawa, Y.2    Kleihues, P.3    Ohgaki, H.4
  • 25
    • 0034745338 scopus 로고    scopus 로고
    • p14ARF deletion and methylation in genetic pathways to glioblastomas
    • Nakamura M, Watanabe T, Klangby U, et al. p14ARF deletion and methylation in genetic pathways to glioblastomas. Brain Pathol 2001; 11(2): 159-68.
    • (2001) Brain Pathol , vol.11 , Issue.2 , pp. 159-168
    • Nakamura, M.1    Watanabe, T.2    Klangby, U.3
  • 26
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293(5532): 1074-80.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 27
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321(5897): 1807-12.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 28
    • 52249090461 scopus 로고    scopus 로고
    • Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: Class II and IV are hypoexpressed in glioblastomas
    • Lucio-Eterovic AK, Cortez MA, Valera ET, et al. Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. BMC Cancer 2008; 8: 243.
    • (2008) BMC Cancer , vol.8 , pp. 243
    • Lucio-Eterovic, A.K.1    Cortez, M.A.2    Valera, E.T.3
  • 29
    • 79952085666 scopus 로고    scopus 로고
    • Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas
    • Campos B, Bermejo JL, Han L, et al. Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas. Cancer Sci 2011; 102(2): 387-92.
    • (2011) Cancer Sci , vol.102 , Issue.2 , pp. 387-392
    • Campos, B.1    Bermejo, J.L.2    Han, L.3
  • 30
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012; 483(7390): 474-8.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 31
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65(14): 6029-33.
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 32
    • 45549089973 scopus 로고    scopus 로고
    • microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    • Kefas B, Godlewski J, Comeau L, et al. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008; 68(10): 3566-72.
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3566-3572
    • Kefas, B.1    Godlewski, J.2    Comeau, L.3
  • 33
    • 34548268220 scopus 로고    scopus 로고
    • Regulation of p27Kip1 by miRNA 221/222 in glioblastoma
    • Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 2007; 6(16): 2005-9.
    • (2007) Cell Cycle , vol.6 , Issue.16 , pp. 2005-2009
    • Gillies, J.K.1    Lorimer, I.A.2
  • 34
    • 48949116262 scopus 로고    scopus 로고
    • miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • Silber J, Lim DA, Petritsch C, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008; 6: 14.
    • (2008) BMC Med , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3
  • 35
    • 77953610190 scopus 로고    scopus 로고
    • Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation
    • Cui JG, Zhao Y, Sethi P, et al. Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation. J Neurooncol 2010; 98(3): 297-304.
    • (2010) J Neurooncol , vol.98 , Issue.3 , pp. 297-304
    • Cui, J.G.1    Zhao, Y.2    Sethi, P.3
  • 36
    • 79956085051 scopus 로고    scopus 로고
    • Human glioma growth is controlled by microRNA-10b
    • Gabriely G, Yi M, Narayan RS, et al. Human glioma growth is controlled by microRNA-10b. Cancer Res 2011; 71(10): 3563-72.
    • (2011) Cancer Res , vol.71 , Issue.10 , pp. 3563-3572
    • Gabriely, G.1    Yi, M.2    Narayan, R.S.3
  • 37
    • 79953309923 scopus 로고    scopus 로고
    • A ten-microRNA expression signature predicts survival in glioblastoma
    • Srinivasan S, Patric IR, Somasundaram K. A ten-microRNA expression signature predicts survival in glioblastoma. PloS One 2011; 6(3): e17438.
    • (2011) PloS One , vol.6 , Issue.3
    • Srinivasan, S.1    Patric, I.R.2    Somasundaram, K.3
  • 39
    • 80655134727 scopus 로고    scopus 로고
    • Context effect: MicroRNA-10b in cancer cell proliferation, spread and death
    • Gabriely G, Teplyuk NM, Krichevsky AM. Context effect: microRNA-10b in cancer cell proliferation, spread and death. Autophagy 2011; 7(11): 1384-6.
    • (2011) Autophagy , vol.7 , Issue.11 , pp. 1384-1386
    • Gabriely, G.1    Teplyuk, N.M.2    Krichevsky, A.M.3
  • 40
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977; 197(4306): 893-5.
    • (1977) Science , vol.197 , Issue.4306 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 41
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366(10): 883-92.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 42
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip NJ, Pedraza A, Chakravarty D, et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci USA 2012; 109(8): 3041-6.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.8 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3
  • 43
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009; 462(7274): 739-44.
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 44
    • 84855710482 scopus 로고    scopus 로고
    • Detection of 2- hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
    • Andronesi OC, Kim GS, Gerstner E, et al. Detection of 2- hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med 2012; 4(116): 116ra4.
    • (2012) Sci Transl Med , vol.4 , Issue.116
    • Andronesi, O.C.1    Kim, G.S.2    Gerstner, E.3
  • 45
    • 12344330398 scopus 로고    scopus 로고
    • Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2- hydroxyglutaric aciduria
    • Struys EA, Salomons GS, Achouri Y, et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2- hydroxyglutaric aciduria. Am J Hum Genet 2005; 76(2): 358-60.
    • (2005) Am J Hum Genet , vol.76 , Issue.2 , pp. 358-360
    • Struys, E.A.1    Salomons, G.S.2    Achouri, Y.3
  • 46
    • 84862329697 scopus 로고    scopus 로고
    • Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma
    • M111.014688
    • Locasale JW, Melman T, Song S, et al. Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma. Mol Cell Proteomics 2012; 11(6): M111.014688.
    • (2012) Mol Cell Proteomics , vol.11 , Issue.6
    • Locasale, J.W.1    Melman, T.2    Song, S.3
  • 47
    • 84877734574 scopus 로고    scopus 로고
    • Malignant Glioma Genotyping by CSF 2-Hydroxyglutarate Oncometabolite and IDH1 Mutation Analysis
    • Balaj L LE, Swanson KD, Asara JM, et al. Malignant Glioma Genotyping by CSF 2-Hydroxyglutarate Oncometabolite and IDH1 Mutation Analysis. Ann Neurol 2012; 72(Suppl 16): S121-32.
    • (2012) Ann Neurol , vol.72 , Issue.SUPPL. 16
    • Balaj, L.L.E.1    Swanson, K.D.2    Asara, J.M.3
  • 48
    • 1842500007 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in recurrent glioblastoma
    • Rich JN, Reardon DA, Peery T, et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 2004; 22(1): 133-42.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 133-142
    • Rich, J.N.1    Reardon, D.A.2    Peery, T.3
  • 49
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • van den Bent MJ, Brandes AA, Rampling R, et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 2009; 27(8): 1268-74.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1268-1274
    • van den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3
  • 50
    • 84861760527 scopus 로고    scopus 로고
    • Differential sensitivity of glioma-versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
    • Vivanco I, Robins HI, Rohle D, et al. Differential sensitivity of glioma-versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov 2012; 2(5): 458-71.
    • (2012) Cancer Discov , vol.2 , Issue.5 , pp. 458-471
    • Vivanco, I.1    Robins, H.I.2    Rohle, D.3
  • 51
    • 84861760526 scopus 로고    scopus 로고
    • Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers
    • Barkovich KJ, Hariono S, Garske AL, et al. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov 2012; 2(5): 450-7.
    • (2012) Cancer Discov , vol.2 , Issue.5 , pp. 450-457
    • Barkovich, K.J.1    Hariono, S.2    Garske, A.L.3
  • 52
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Science Transl Med 2011; 3(75): 75ra26.
    • (2011) Science Transl Med , vol.3 , pp. 75
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 53
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers
    • 120ra17
    • Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. Sci Transl Med 2012; 4(120): 120ra17.
    • (2012) Sci Transl Med , vol.4 , Issue.120
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 54
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke AB, Zejnullahu K, Wu YL, et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 2010; 17(1): 77-88.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.L.3
  • 55
    • 84863754907 scopus 로고    scopus 로고
    • VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    • Lu KV, Chang JP, Parachoniak CA, et al. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell 2012; 22(1): 21-35.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 21-35
    • Lu, K.V.1    Chang, J.P.2    Parachoniak, C.A.3
  • 56
    • 77956060394 scopus 로고    scopus 로고
    • High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
    • Clarke JL, Pao W, Wu N, Miller VA, Lassman AB. High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J Neurooncol 2010; 99(2): 283-6.
    • (2010) J Neurooncol , vol.99 , Issue.2 , pp. 283-286
    • Clarke, J.L.1    Pao, W.2    Wu, N.3    Miller, V.A.4    Lassman, A.B.5
  • 57
    • 33947385893 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420
    • Broniscer A, Panetta JC, O'Shaughnessy M, et al. Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin Cancer Res 2007; 13(5): 1511-5.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1511-1515
    • Broniscer, A.1    Panetta, J.C.2    O'Shaughnessy, M.3
  • 58
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 2010; 28(31): 4722-9.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3
  • 59
    • 84865528882 scopus 로고    scopus 로고
    • NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality
    • Stupp R, Wong ET, Kanner AA, et al. NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality. Eur J Cancer 2012; 48(14): 2192-202.
    • (2012) Eur J Cancer , vol.48 , Issue.14 , pp. 2192-2202
    • Stupp, R.1    Wong, E.T.2    Kanner, A.A.3
  • 60
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG, Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005; 5(9): 689-98.
    • (2005) Nat Rev Cancer , vol.5 , Issue.9 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 61
    • 4344688936 scopus 로고    scopus 로고
    • 13-cisretinoic acid in the treatment of recurrent glioblastoma multiforme
    • See SJ, Levin VA, Yung WK, Hess KR, Groves MD. 13-cisretinoic acid in the treatment of recurrent glioblastoma multiforme. Neuro Oncol 2004; 6(3): 253-8.
    • (2004) Neuro Oncol , vol.6 , Issue.3 , pp. 253-258
    • See, S.J.1    Levin, V.A.2    Yung, W.K.3    Hess, K.R.4    Groves, M.D.5
  • 62
    • 80054015235 scopus 로고    scopus 로고
    • Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
    • Kast RE, Karpel-Massler G, Halatsch ME. Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin? Br J Pharmacol 2011; 164(5): 1393-6.
    • (2011) Br J Pharmacol , vol.164 , Issue.5 , pp. 1393-1396
    • Kast, R.E.1    Karpel-Massler, G.2    Halatsch, M.E.3
  • 63
    • 77951028897 scopus 로고    scopus 로고
    • Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
    • Zuccoli G, Marcello N, Pisanello A, et al. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab (Lond) 2010; 7: 33.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 33
    • Zuccoli, G.1    Marcello, N.2    Pisanello, A.3
  • 64
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 2011; 11(12): 849-64.
    • (2011) Nat Rev Cancer , vol.11 , Issue.12 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 65
    • 67349238629 scopus 로고    scopus 로고
    • Oncogenic role of microRNAs in brain tumors
    • Pang JC, Kwok WK, Chen Z, Ng HK. Oncogenic role of microRNAs in brain tumors. Acta Neuropathol 2009; 117(6): 599-611.
    • (2009) Acta Neuropathol , vol.117 , Issue.6 , pp. 599-611
    • Pang, J.C.1    Kwok, W.K.2    Chen, Z.3    Ng, H.K.4
  • 66
    • 80054937128 scopus 로고    scopus 로고
    • CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells
    • Schraivogel D, Weinmann L, Beier D, et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J 2011; 30(20): 4309-22.
    • (2011) EMBO J , vol.30 , Issue.20 , pp. 4309-4322
    • Schraivogel, D.1    Weinmann, L.2    Beier, D.3
  • 67
    • 84860448293 scopus 로고    scopus 로고
    • Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells
    • Lang MF, Yang S, Zhao C, et al. Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells. PloS One 2012; 7(4): e36248.
    • (2012) PloS One , vol.7 , Issue.4
    • Lang, M.F.1    Yang, S.2    Zhao, C.3
  • 68
    • 23044464236 scopus 로고    scopus 로고
    • Extensive modulation of a set of microRNAs in primary glioblastoma
    • Ciafre SA, Galardi S, Mangiola A, et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 2005; 334(4): 1351-8.
    • (2005) Biochem Biophys Res Commun , vol.334 , Issue.4 , pp. 1351-1358
    • Ciafre, S.A.1    Galardi, S.2    Mangiola, A.3
  • 69
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski J, Nowicki MO, Bronisz A, et al. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 2008; 68(22): 9125-30.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3
  • 70
    • 77955719235 scopus 로고    scopus 로고
    • MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance
    • Guan Y, Mizoguchi M, Yoshimoto K, et al. MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance. Clin Cancer Res 2010; 16(16): 4289-97.
    • (2010) Clin Cancer Res , vol.16 , Issue.16 , pp. 4289-4297
    • Guan, Y.1    Mizoguchi, M.2    Yoshimoto, K.3
  • 71
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008; 18(3): 350-9.
    • (2008) Cell Res , vol.18 , Issue.3 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3    Nie, D.4    Sheng, S.5    Mo, Y.Y.6
  • 72
    • 76649130555 scopus 로고    scopus 로고
    • Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
    • Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci USA 2010; 107(5): 2183-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.5 , pp. 2183-2188
    • Kim, H.1    Huang, W.2    Jiang, X.3    Pennicooke, B.4    Park, P.J.5    Johnson, M.D.6
  • 73
    • 84858987120 scopus 로고    scopus 로고
    • miR-34a Repression in Proneural Malignant Gliomas Upregulates Expression of Its Target PDGFRA and Promotes Tumorigenesis
    • Silber J, Jacobsen A, Ozawa T, et al. miR-34a Repression in Proneural Malignant Gliomas Upregulates Expression of Its Target PDGFRA and Promotes Tumorigenesis. PloS One 2012; 7(3): e33844.
    • (2012) PloS One , vol.7 , Issue.3
    • Silber, J.1    Jacobsen, A.2    Ozawa, T.3
  • 74
    • 79951810604 scopus 로고    scopus 로고
    • MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8
    • Fang L, Deng Z, Shatseva T, et al. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8. Oncogene 2011; 30(7): 806-21.
    • (2011) Oncogene , vol.30 , Issue.7 , pp. 806-821
    • Fang, L.1    Deng, Z.2    Shatseva, T.3
  • 75
    • 84859757525 scopus 로고    scopus 로고
    • Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases
    • Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, et al. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene 2012; 31(15): 1884-95.
    • (2012) Oncogene , vol.31 , Issue.15 , pp. 1884-1895
    • Papagiannakopoulos, T.1    Friedmann-Morvinski, D.2    Neveu, P.3
  • 76
    • 80052973904 scopus 로고    scopus 로고
    • Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines
    • Xu J, Liao X, Lu N, Liu W, Wong CW. Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines. Int J Cancer 2011; 129(10): 2527-31.
    • (2011) Int J Cancer , vol.129 , Issue.10 , pp. 2527-2531
    • Xu, J.1    Liao, X.2    Lu, N.3    Liu, W.4    Wong, C.W.5
  • 77
    • 84862884178 scopus 로고    scopus 로고
    • miR-155 is upregulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors
    • D'Urso PI, D'Urso OF, Storelli C, et al. miR-155 is upregulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors. Int J Oncol 2012; 41(1): 228-34.
    • (2012) Int J Oncol , vol.41 , Issue.1 , pp. 228-234
    • D'Urso, P.I.1    D'Urso, O.F.2    Storelli, C.3
  • 78
    • 80053355727 scopus 로고    scopus 로고
    • MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma
    • Zhang Z, Tang H, Wang Z, et al. MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma. Mol Cancer 2011; 10: 124.
    • (2011) Mol Cancer , vol.10 , pp. 124
    • Zhang, Z.1    Tang, H.2    Wang, Z.3
  • 79
    • 84863031502 scopus 로고    scopus 로고
    • MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A
    • Yue X, Wang P, Xu J, et al. MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. Oncol Rep 2012; 27(4): 1200-6.
    • (2012) Oncol Rep , vol.27 , Issue.4 , pp. 1200-1206
    • Yue, X.1    Wang, P.2    Xu, J.3
  • 80
    • 52049096593 scopus 로고    scopus 로고
    • MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
    • Gal H, Pandi G, Kanner AA, et al. MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochem Biophys Res Commun 2008; 376(1): 86-90.
    • (2008) Biochem Biophys Res Commun , vol.376 , Issue.1 , pp. 86-90
    • Gal, H.1    Pandi, G.2    Kanner, A.A.3
  • 81
    • 84860324785 scopus 로고    scopus 로고
    • MiR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1
    • Wang L, Shi M, Hou S, et al. MiR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1. FEBS Lett 2012; 586(9): 1312-7.
    • (2012) FEBS Lett , vol.586 , Issue.9 , pp. 1312-1317
    • Wang, L.1    Shi, M.2    Hou, S.3
  • 82
    • 80052030282 scopus 로고    scopus 로고
    • Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme
    • Yan W, Zhang W, Sun L, et al. Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme. Brain Res 2011; 1411: 108-15.
    • (2011) Brain Res , vol.1411 , pp. 108-115
    • Yan, W.1    Zhang, W.2    Sun, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.