Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Gugliesi, Francesca ^a   Bawadekar, Mandar ^b   de Andrea, Marco ^a,b   Dell'Oste, Valentina ^a   Caneparo, Valeria ^b   Tincani, Angela ^c   Gariglio, Marisa ^b   Landolfo, Santo ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; PROTEIN ANTIBODY; PROTEIN IFI16; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; BINDING SITE; CELL DAMAGE; CELL MEMBRANE; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; MAJOR CLINICAL STUDY; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIBODIES, NEUTRALIZING; AUTOIMMUNE DISEASES; CELL MEMBRANE; CELL MOVEMENT; CELL NUCLEUS; DNA; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; KINETICS; NUCLEAR PROTEINS; PHOSPHOPROTEINS;

EID: 84877757789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063045     Document Type: Article

References (43)

1. Elkon KB, Wiedeman A, (2012) Type I IFN system in the development and manifestations of SLE. Curr Opin Rheumatol 24: 499-505.
2. Pollard KM, Hultman P, Toomey CB, Cauvi DM, Hoffman HM, et al. (2012) Definition of IFN-gamma-related pathways critical for chemically-induced systemic autoimmunity. J Autoimmun 39: 323-331.
3. Choubey D, Moudgil KD, (2011) Interferons in autoimmune and inflammatory diseases: regulation and roles. J Interferon Cytokine Res 31: 857-865.
4. Crow MK, (2010) Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res Ther 12Suppl 1: S5.
5. Ronnblom L, (2010) Potential role of IFNalpha in adult lupus. Arthritis Res Ther 12Suppl 1: S3.
6. Higgs BW, Liu Z, White B, Zhu W, White WI, et al. (2011) Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis 70: 2029-2036.
7. Mavragani CP, Crow MK, (2010) Activation of the type I interferon pathway in primary Sjogren's syndrome. J Autoimmun 35: 225-231.
8. Kong JS, Teuber SS, Gershwin ME, (2006) Potential adverse events with biologic response modifiers. Autoimmun Rev 5: 471-485.
9. Sozzani S, Bosisio D, Scarsi M, Tincani A, (2010) Type I interferons in systemic autoimmunity. Autoimmunity 43: 196-203.
10. Higgs BW, Zhu W, Richman L, Fiorentino DF, Greenberg SA, et al. (2012) Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patients. Int J Rheum Dis 15: 25-35.
11. Selmi C, Lleo A, Zuin M, Podda M, Rossaro L, et al. (2006) Interferon alpha and its contribution to autoimmunity. Curr Opin Investig Drugs 7: 451-456.
12. Bach JF, (2005) Infections and autoimmune diseases. J Autoimmun 25Suppl: 74-80.
13. Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, et al. (2012) The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evol Biol 12: 140.
14. Gariglio M, Mondini M, De Andrea M, Landolfo S, (2011) The multifaceted interferon-inducible p200 family proteins: from cell biology to human pathology. J Interferon Cytokine Res 31: 159-172.
15. Gariglio M, Azzimonti B, Pagano M, Palestro G, De Andrea M, et al. (2002) Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. J Interferon Cytokine Res 22: 815-821.
16. Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, et al. (2010) Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol 84: 7803-7814.
17. Li T, Diner BA, Chen J, Cristea IM, (2012) Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci U S A 109: 10558-10563.
18. Gariano GR, Dell'Oste V, Bronzini M, Gatti D, Luganini A, et al. (2012) The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog 8: e1002498.
19. Unterholzner L, Bowie AG, (2011) Innate DNA sensing moves to the nucleus. Cell Host Microbe 9: 351-353.
20. Sponza S, De Andrea M, Mondini M, Gugliesi F, Gariglio M, et al. (2009) Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha. Cell Immunol 257: 55-60.
21. Gugliesi F, Mondini M, Ravera R, Robotti A, de Andrea M, et al. (2005) Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol 77: 820-829.
22. Mondini M, Costa S, Sponza S, Gugliesi F, Gariglio M, et al. (2010) The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity. Autoimmunity 43: 226-231.
23. Gugliesi F, De Andrea M, Mondini M, Cappello P, Giovarelli M, et al. (2010) The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. J Autoimmun 35: 114-123.
24. Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, et al. (2007) A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem 282: 33515-33529.
25. Rekvig OP, Putterman C, Casu C, Gao HX, Ghirardello A, et al. (2012) Autoantibodies in lupus: culprits or passive bystanders? Autoimmun Rev 11: 596-603.
26. Mondini M, Vidali M, Airo P, De Andrea M, Riboldi P, et al. (2007) Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann N Y Acad Sci 1110: 47-56.
27. Mondini M, Vidali M, De Andrea M, Azzimonti B, Airo P, et al. (2006) A novel autoantigen to differentiate limited cutaneous systemic sclerosis from diffuse cutaneous systemic sclerosis: the interferon-inducible gene IFI16. Arthritis Rheum 54: 3939-3944.
28. Costa S, Mondini M, Caneparo V, Afeltra A, Airo P, et al. (2011) Detection of anti-IFI16 antibodies by ELISA: clinical and serological associations in systemic sclerosis. Rheumatology (Oxford) 50: 674-681.
29. Costa S, Borgogna C, Mondini M, De Andrea M, Meroni PL, et al. (2011) Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing. Br J Dermatol 164: 282-290.
30. Schattgen SA, Fitzgerald KA, (2011) The PYHIN protein family as mediators of host defenses. Immunol Rev 243: 109-118.
31. Baggetta R, De Andrea M, Gariano GR, Mondini M, Ritta M, et al. (2010) The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response. Eur J Immunol 40: 2182-2189.
32. Pauwels R, Balzarini J, Baba M, Snoeck R, Schols D, et al. (1988) Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J Virol Methods 20: 309-321.
33. Gugliesi F, Dell'oste V, De Andrea M, Baggetta R, Mondini M, et al. (2011) Tumor-derived endothelial cells evade apoptotic activity of the interferon-inducible IFI16 gene. J Interferon Cytokine Res 31: 609-618.
34. Koristka S, Cartellieri M, Arndt C, Bippes CC, Feldmann A, et al. (2013) Retargeting of regulatory T cells to surface-inducible autoantigen La/SS-B. J Autoimmun In press.
35. Imai Y, Leung CK, Friesen HG, Shiu RP, (1982) Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture. Cancer Res 42: 4394-4398.
36. Coleman JW, Godfrey RC, (1981) The number and affinity of IgE receptors on dispersed human lung mast cells. Immunology 44: 859-863.
37. Guiducci S, Distler O, Distler JH, Matucci-Cerinic M, (2008) Mechanisms of vascular damage in SSc-implications for vascular treatment strategies. Rheumatology (Oxford) 47Suppl 5: v18-20.
38. Bianchi ME, (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1-5.
39. Harris HE, Andersson U, Pisetsky DS, (2012) HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol 8: 195-202.
40. Keating SE, Baran M, Bowie AG, (2011) Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol 32: 574-581.
41. Kaplan MJ, (2009) Endothelial damage and autoimmune diseases. Autoimmunity 42: 561-562.
42. Rashtak S, Pittelkow MR, (2008) Skin involvement in systemic autoimmune diseases. Curr Dir Autoimmun 10: 344-358.
43. Bachmann M, Zaubitzer T, Muller WE, (1992) The autoantigen La/SSB: detection on and uptake by mitotic cells. Exp Cell Res 201: 387-398.