Tumor-targeting Salmonella typhimurium, a natural tool for activation of prodrug 6MePdR and their combination therapy in murine melanoma model

Applied Microbiology and Biotechnology

Volumn 97, Issue 10, 2013, Pages 4393-4401

  Chen, Guo ^a   Tang, Bo ^a,c   Yang, Bing Ya ^a   Chen, Jian Xiang ^a   Zhou, Jia Hua ^b   Li, Jia Huang ^a   Hua, Zi Chun ^a,c  

^a NANJING UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

^c Jiangsu TargetPharma Laboratories Inc   (China)

Author keywords

Bacteria prodrug therapy system; Purine nucleoside phosphorylase; Salmonella typhimurium; Tumor therapy

Indexed keywords

ANTI-TUMOR ACTIVITIES; COLORIMETRIC ASSAYS; COMBINATION TREATMENTS; ENZYME-PRODRUG THERAPIES; PURINE NUCLEOSIDE PHOSPHORYLASE; SALMONELLA TYPHIMURIUM; SYSTEMIC ADMINISTRATION; TUMOR THERAPY;

ASSAYS; BIOMOLECULES; DERMATOLOGY; ENZYME ACTIVITY; ESCHERICHIA COLI; ONCOLOGY; PHOSPHORYLATION; SALMONELLA; T-CELLS; TUMORS;

GENE THERAPY;

6 METHYLPURINE; 6 METHYLPURINE 2' DEOXYRIBOSIDE; ANTINEOPLASTIC AGENT; PRODRUG; PURINE NUCLEOSIDE PHOSPHORYLASE; TETRAZOLIUM; UNCLASSIFIED DRUG; VNP 20009;

CANCER; COLIFORM BACTERIUM; COLORIMETRY; DISEASE TREATMENT; DRUG; ENZYME ACTIVITY; RODENT; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CD8+ T LYMPHOCYTE; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTIC INFILTRATION; MELANOMA; MOUSE; NONHUMAN; SALMONELLA TYPHIMURIUM;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; IN SITU NICK-END LABELING; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PRODRUGS; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; MURINAE; MUS; SALMONELLA TYPHIMURIUM;

EID: 84877747800     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4321-8     Document Type: Article

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