The Protective Effects of the Proteasome Inhibitor Bortezomib (Velcade) on Ischemia-Reperfusion Injury in the Rat Retina

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chen, Fang Ting ^a,b,c   Yang, Chung May ^b,c   Yang, Chang Hao ^b,c  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; ACROLEIN; BORTEZOMIB; CD68 ANTIGEN; HEME OXYGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXIREDOXIN; PROTEIN BAX; PROTEIN P53; THIOREDOXIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ELECTRORETINOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; LOW DRUG DOSE; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RETINA CELL; RETINA GANGLION CELL; RETINA INJURY; TREATMENT RESPONSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL MARKERS; BORONIC ACIDS; CELL COUNT; CHYMOTRYPSIN; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINA; RETINAL GANGLION CELLS; RNA, MESSENGER;

EID: 84877739071     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064262     Document Type: Article

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