Phosphatidylserine-containing liposomes promote maximal survival of retinal neurons after ischemic injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 11, 2009, Pages 1755-1759

  Dvoriantchikova, Galina ^a   Agudelo, Christian ^b   Hernandez, Eleut ^a   Shestopalov, Valery I ^a,b   Ivanov, Dmitry ^a,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

Author keywords

Apoptosis; Inflammation; Ischemia; Liposomes; Phosphatidylserine; Retinal pathology

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; DISEASE SEVERITY; DRUG EFFECT; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; RETINA ISCHEMIA; RETINA NERVE CELL; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; CELL DEATH; CELL SURVIVAL; CYTOKINES; DISEASE MODELS, ANIMAL; LIPOSOMES; MALE; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLSERINES; REPERFUSION INJURY; RETINA;

EID: 71949122183     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.95     Document Type: Article

References (12)

1. Bratton DL, Henson PM (2008) Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol 18:R76-9
2. Chapat S, Frey V, Claperon N, Bouchaud C, Puisieux F, Couvreur P, Rossignol P, Delattre J (1991) Efficiency of liposomal ATP in cerebral ischemia: bioavailability features. Brain Res Bull 26:339-342
3. Crotty S, Fitzgerald P, Tuohy E, Harris DM, Fisher A, Mandel A, Bolton AE, Sullivan AM, Nolan Y (2008) Neuroprotective effects of novel phosphatidylglycerol-based phospholipids in the 6-hydroxydopamine model of Parkinson's disease. Eur J Neurosci 27: 294-300
4. Fadok VA, Bratton DL, Guthrie L, Henson PM (2001) Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol 166:6847-6854 (Pubitemid 32467230)
5. Feigin VL (2005) Stroke epidemiology in the developing world. Lancet 365:2160-2161
6. Hashioka S, Han YH, Fujii S, Kato T, Monji A, Utsumi H, Sawada M, Nakanishi H, Kanba S (2007) Phosphatidylserine and phosphatidylcholine- containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Free Radic Biol Med 42:945-954 (Pubitemid 46356888)
7. Henson PM, Bratton DL, Fadok VA (2001) The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol 2:627-633
8. Hoffmann PR, Kench JA, Vondracek A, Kruk E, Daleke DL, Jordan M, Marrack P, Henson PM, Fadok VA (2005) Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol 174:1393-1404
9. Huynh ML, Fadok VA, Henson PM (2002) Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41-50
10. Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568
11. Minghetti L, Ajmone-Cat MA, De Berardinis MA, De Simone R (2005) Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation. Brain Res Brain Res Rev 48:251-256 (Pubitemid 40585756)
12. Nolan Y, Martin D, Campbell VA, Lynch MA (2004) Evidence of a protective effect of phosphatidylserine-containing liposomes on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus. J Neuroimmunol 151:12-23 (Pubitemid 38624395)