Controlled release of metronidazole from composite poly-ε- caprolactone/alginate (PCL/alginate) rings for dental implants

Dental Materials

Volumn 29, Issue 6, 2013, Pages 656-665

  Lan, Shih Feng ^a   Kehinde, Timilehin ^b   Zhang, Xiangming ^a   Khajotia, Sharukh ^a   Schmidtke, David W ^a,b   Starly, Binil ^a,b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b University of Oklahoma   (United States)

Author keywords

Alginate; Dental implants; Localized drug delivery; Metronidazole; Poly caprolactone; Solvent casting

Indexed keywords

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CAPROLACTONE; CONTROLLABLE DRUG RELEASE; METRONIDAZOLE; MINIMAL INHIBITORY CONCENTRATION; RELEASE CHARACTERISTICS; SOLVENT CASTING;

ALGINATE; BACTERICIDES; DENTAL PROSTHESES; DRUG DELIVERY;

DRUG PRODUCTS;

ALGINIC ACID; ANTIINFECTIVE AGENT; BIOMATERIAL; GLUCURONIC ACID; HEXURONIC ACID; METRONIDAZOLE; POLYCAPROLACTONE; POLYESTER; DELAYED RELEASE FORMULATION; HYDROGEL; TOOTH IMPLANT;

ARTICLE; BIODEGRADABLE IMPLANT; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG DELIVERY SYSTEM; ELASTICITY; EQUIPMENT; EQUIPMENT DESIGN; HUMAN; HYDROGEL; MECHANICAL STRESS; MICROBIAL SENSITIVITY TEST; TIME; TOOTH IMPLANT; YOUNG MODULUS; DEVICES;

ABSORBABLE IMPLANTS; ALGINATES; ANTI-INFECTIVE AGENTS; BIOCOMPATIBLE MATERIALS; DELAYED-ACTION PREPARATIONS; DENTAL IMPLANTS; DIFFUSION; DRUG DELIVERY SYSTEMS; ELASTIC MODULUS; ELASTICITY; EQUIPMENT DESIGN; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGELS; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; POLYESTERS; STRESS, MECHANICAL; TIME FACTORS;

EID: 84877729508     PISSN: 01095641     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dental.2013.03.014     Document Type: Article

References (56)

1. A.D. Pye, D.E. Lockhart, M.P. Dawson, C.A. Murray, and A.J. Smith A review of dental implants and infection Journal of Hospital Infection 72 2009 104 110
2. A. Lee, and H.L. Wang Biofilm related to dental implants Implant Dentistry 19 2010 387 393
3. B. Grossner-Schreiber, J. Teichmann, M. Hannig, C. Dorfer, D.F. Wenderoth, and S.J. Ott Modified implant surfaces show different biofilm compositions under in vivo conditions Clinical Oral Implants Research 20 2009 817 826
4. M.M. Furst, G.E. Salvi, N.P. Lang, and G.R. Persson Bacterial colonization immediately after installation on oral titanium implants Clinical Oral Implants Research 18 2007 501 508
5. K. Subramani, R.E. Jung, A. Molenberg, and C.H. Hammerle Biofilm on dental implants: a review of the literature International Journal of Oral and Maxillofacial Implants 24 2009 616 626
6. A.H. Rickard, P. Gilbert, N.J. High, P.E. Kolenbrander, and P.S. Handley Bacterial coaggregation: an integral process in the development of multi-species biofilms Trends in Microbiology 11 2003 94 100
7. I.W. Sutherland, K.A. Hughes, L.C. Skillman, and K. Tait The interaction of phage and biofilms FEMS Microbiology Letters 232 2004 1 6
8. S.S. Branda, F. Chu, D.B. Kearns, R. Losick, and R. Kolter A major protein component of the Bacillus subtilis biofilm matrix Molecular Microbiology 59 2006 1229 1238
9. P.D. Marsh Dental plaque as a biofilm: the significance of pH in health and caries Compendium of Continuing Education in Dentistry 30 2009 76 77
10. S.S. Socransky, and A.D. Haffajee Dental biofilms: difficult therapeutic targets Periodontology 2000 28 2002 12 55
11. L.G. Harris, and R.G. Richards Staphylococci and implant surfaces: a review Injury 37 Suppl. 2 2006 S3 S14
12. U. Noyan, S. Yilmaz, B. Kuru, T. Kadir, O. Acar, and E. Buget A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients Journal of Clinical Periodontology 24 1997 158 165
13. S. Lofmark, C. Edlund, and C.E. Nord Metronidazole is still the drug of choice for treatment of anaerobic infections Clinical Infectious Diseases 50 Suppl 1 2010 S16 S23
14. R.M. Palmer, J.P. Matthews, and R.F. Wilson Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study British Dental Journal 184 1998 548 552
15. K. Stoltze Elimination of elyzol 25% dentalgel matrix from periodontal pockets Journal of Clinical Periodontology 22 1995 185 187
16. Y. Wan, B. Xiao, S. Dalai, X. Cao, and Q. Wu Development of polycaprolactone/chitosan blend porous scaffolds Journal of Materials Science: Materials in Medicine 20 2009 719 724
17. C.G. Pitt, M.M. Gratzl, G.L. Kimmel, J. Surles, and A. Schindler Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (epsilon-caprolactone), and their copolymers in vivo Biomaterials 2 1981 215 220
18. K.D. Kyun, K.S. Yun, J.S. Young, C.C. Pyoung, and S.S. Heui Development of minocycline containing polycaprolactone film as a local drug delivery Journal of Korean Dental Association 28 1990 279 290
19. M.C. Bottino, V. Thomas, and G.M. Janowski A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration Acta Biomaterialia 7 2011 216 224
20. B. Inanc, Y.E. Arslan, S. Seker, A.E. Elcin, and Y.M. Elcin Periodontal ligament cellular structures engineered with electrospun poly(dl-lactide-co- glycolide) nanofibrous membrane scaffolds Journal of Biomedical Materials Research-Applied Biomaterials 90 2009 186 195
21. M. Zamani, M. Morshed, J. Varshosaz, and M. Jannesari Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases European Journal of Pharmaceutics and Biopharmaceutics 75 2010 179 185
22. O. Jeon, K.H. Bouhadir, J.M. Mansour, and E. Alsberg Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties Biomaterials 30 2009 2724 2734
23. M. George, and T.E. Abraham Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan - a review J Control Release 114 2006 1 14
24. V.V. Nandini, K.V. Venkatesh, and K.C. Nair Alginate impressions: a practical perspective Journal of Conservative Dentistry 11 2008 37 41
25. I.R. Matthew, R.M. Browne, J.W. Frame, and B.G. Millar Subperiosteal behaviour of alginate and cellulose wound dressing materials Biomaterials 16 1995 275 278
26. T.W. Wong Alginate graft copolymers and alginate-co-excipient physical mixture in oral drug delivery Journal of Pharmacy and Pharmacology 63 2011 1497 1512
27. C.V. Liew, L.W. Chan, A.L. Ching, and P.W. Heng Evaluation of sodium alginate as drug release modifier in matrix tablets International Journal of Pharmaceutics 309 2006 25 37
28. K.E. Uhrich, S.M. Cannizzaro, R.S. Langer, and K.M. Shakesheff Polymeric systems for controlled drug release Chemical Reviews 99 1999 3181 3198
29. N.A. Peppas Analysis of Fickian and non-Fickian drug release from polymers Pharmaceutica Acta Helvetiae 60 1985 110 111
30. R.W. Baker, and H.S. Lonsdale Controlled release: mechanisms and rates A.C. Tanquary, R.E. Lacey, Controlled Release of Biologicallyl Active Agents 1974 Plenum Press New York 15 71
31. A.W. Hixson, and J.H. Crowell Dependence of reaction velocity upon surface and agitation: I-Theoretical condideration Industrial and Engineering Chemistry 23 1931 923 931
32. T. Higuchi Rate of release of medicaments from ointment bases containing drugs in suspension Journal of Pharmaceutical Sciences 50 1961 874 875
33. K.A. Gates, H. Grad, P. Birek, and P.I. Lee A new bioerodible polymer insert for the controlled release of metronidazole Pharmaceutical Research 11 1994 1605 1609
34. A. Ahuja, J. Ali, and S. Rahman Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterisation Pharmazie 61 2006 25 29
35. S. Eshraghi, and S. Das Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering Acta Biomaterialia 6 7 2010 2467 2476
36. S.-J. Liu, F.-J. Chiang, C.-Y. Hsiao, Y.-C. Kau, and K.-S. Liu Fabrication of balloon-expandable self-lock drug-eluting polycaprolactone stents using micro-injection molding and spray coating techniques Annals of Biomedical Engineering 38 10 2010 3185 3194
37. R.E. Forster, F. Thurmer, C. Wallrapp, A.W. Lloyd, W. Macfarlane, and G.J. Phillips Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation Journal of Materials Science Materials in Medicine 21 2010 2243 2251
38. H. Sun, L. Mei, C. Song, X. Cui, and P. Wang The in vivo degradation, absorption and excretion of PCL-based implant Biomaterials 27 2006 1735 1740
39. Y. Shifrovitch, I. Binderman, H. Bahar, I. Berdicevsky, and M. Zilberman Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets Journal of Periodontology 80 2009 330 337
40. C.G. Zalavras, M.J. Patzakis, and P. Holtom Local antibiotic therapy in the treatment of open fractures and osteomyelitis Clinical Orthopaedics and Related Research 427 2004 86 93
41. W.J. Killoy Chemical treatment of periodontitis: local delivery of antimicrobials International Dental Journal 48 June (3 Suppl 1) 1998 305 315
42. R. Vijayaraghavan, V.M. Mathian, A.M. Sundaram, R. Karunakaran, and S. Vinodh Triple antibiotic paste in root canal therapy Journal of Pharmacy and Bioallied Science Suppl. 2 2012 S230 S233
43. R. Ordinola-Zapata, C.M. Bramante, P.G. Minotti, B.C. Cavenago, R.B. Garcia, and N. Bernardineli Antimicrobial activity of triantibiotic paste, 2% chlorhexidine gel, and calcium hydroxide on an intraoral-infected dentin biofilm model Journal of Endodontics 39 January (1) 2013 115 118
44. E. Gjorgievska, S. Apostolska, A. Dimkov, J.W. Nicholson, and A. Kaftandzieva Incorporation of antimicrobial agents can be used to enhance the antibacterial effect of endodontic sealers Dental Materials 29 3 2013 e29 e34
45. N. Namba, Y. Yoshida, N. Nagaoka, S. Takashima, K. Matsuura-Yoshimoto, and H. Maeda Antibacterial effect of bactericide immobilized in resin matrix Dental Materials 25 4 2009 424 430
46. E. De Giglio, D. Cafagna, S. Cometa, A. Allegretta, A. Pedico, and L.C. Giannossa An innovative, easily fabricated, silver nanoparticle-based titanium implant coating: development and analytical characterization Analytical and Bioanalytical Chemistry August 2012 809 816
47. 2 supported silver/zinc-silver materials Dental Materials 24 2 2008 244 249
48. Y. Han, Q. Zeng, E.L.D. Wang, H. He, and H. Liu Sustained topical delivery of insulin from fibrin gel loaded with poly(lactic-co-glycolic Acid) microspheres improves the biomechanical retention of titanium implants in type 1 diabetic rats Journal of Oral and Maxillofacial Surgery 70 October (10) 2012 2299 2308
49. J. Bakó, M. Vecsernyés, Z. Ujhelyi, I.B. Kovácsné, I. Borbíró, and T. Bíró Composition and characterization of in situ usable light cured dental drug delivery hydrogel system Journal of Materials Science Materials in Medicine December 2012 659 666
50. M. Reise, R. Wyrwa, U. Müller, M. Zylinski, A. Völpel, and M. Schnabelrauch Release of metronidazole from electrospun poly(l-lactide-co-d/d- lactide) fibers for local periodontitis treatment Dental Materials 28 February (2) 2012 179 188
51. E.B. Hunziker, L. Enggist, A. Küffer, D. Buser, and Y. Liu Osseointegration: the slow delivery of BMP-2 enhances osteoinductivity Bone 51 July (1) 2012 98 106
52. M.A. Woodruff, and D.W. Hutmacher The return of a forgotten polymer - polycaprolactone in the 21st century Progress in Polymer Science 35 October (10) 2010 1217 1256
53. A. Gopferich, D. Karydas, and R. Langer Predicting drug-release from cylindric polyanhydride matrix discs European Journal of Pharmaceutics and Biopharmaceutics 41 1995 81 87
54. J.E. Bergsma, W.C. de Bruijn, F.R. Rozema, R.R.M. Bos, and G. Boering Late degradation tissue response to poly(lactide) bone plates and screws Biomaterials 16 1995 25 31
55. P.A. Gunatillake, and R. Adhikari Biodegradable synthetic polymers for tissue engineering European Cells and Materials 5 2003 1 16
56. C.X.F. Lam, D.W. Hutmacher, J.-T. Schantz, M.A. Woodruff, and S.H. Teoh Evaluation of poly-caprolactone scaffold degradation for 6 months in vitro and in vivo Journal of Biomedical Materials Research-Applied Biomaterials 90 2008 906 919