A structural basis for selective dimerization by NF-κB RelB

Journal of Molecular Biology

Volumn 425, Issue 11, 2013, Pages 1934-1945

  Vu, Don ^a   Huang, De Bin ^a   Vemu, Annapurna ^a   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

dimer interface; gene expression; NF B; transcription factor; x ray crystallography

Indexed keywords

I KAPPA B; TRANSCRIPTION FACTOR;

ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INDUCTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT;

EID: 84877713439     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.02.020     Document Type: Article

References (29)

1. M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
2. A. Hoffmann, G. Natoli, and G. Ghosh Transcriptional regulation via the NF-kappaB signaling module Oncogene 25 2006 6706 6716
3. S.T. Smale Dimer-specific regulatory mechanisms within the NF-kappaB family of transcription factors Immunol. Rev. 246 2012 193 204
4. G. Ghosh, V.Y. Wang, D.B. Huang, and A. Fusco NF-kappaB regulation: lessons from structures Immunol. Rev. 246 2012 36 58
5. D.B. Huang, T. Huxford, Y.Q. Chen, and G. Ghosh The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits Structure 5 1997 1427 1436
6. D.J. Hart, R.E. Speight, J.D. Sutherland, and J.M. Blackburn Analysis of the NF-kappaB p50 dimer interface by diversity screening J. Mol. Biol. 310 2001 563 575
7. C.B. Phelps, L.L. Sengchanthalangsy, S. Malek, and G. Ghosh Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers J. Biol. Chem. 275 2000 24392 24399
8. S. Ghosh, and M. Karin Missing pieces in the NF-kappaB puzzle Cell 109 2002 S81 S96
9. U. Senftleben, Y. Cao, G. Xiao, F.R. Greten, G. Krahn, and G. Bonizzi Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway Science 293 2001 1495 1499
10. G. Bonizzi, and M. Karin The two NF-kappaB activation pathways and their role in innate and adaptive immunity Trends Immunol. 25 2004 280 288
11. D.S. Weih, Z.B. Yilmaz, and F. Weih Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines J. Immunol. 167 2001 1909 1919
12. Z.B. Yilmaz, D.S. Weih, V. Sivakumar, and F. Weih RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF EMBO J. 22 2003 121 130
13. V.F. Shih, J. Davis-Turak, M. Macal, J.Q. Huang, J. Ponomarenko, and J.D. Kearns Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-kappaB pathways Nat. Immunol. 13 2012 1162 1170
14. S. Saccani, S. Pantano, and G. Natoli Modulation of NF-kappaB activity by exchange of dimers Mol. Cell 11 2003 1563 1574
15. A.J. Fusco, O.V. Savinova, R. Talwar, J.D. Kearns, A. Hoffmann, and G. Ghosh Stabilization of RelB requires multidomain interactions with p100/p52 J. Biol. Chem. 283 2008 12324 12332
16. D.B. Huang, D. Vu, and G. Ghosh NF-kappaB RelB forms an intertwined homodimer Structure 13 2005 1365 1373
17. A.K. Moorthy, D.B. Huang, V.Y. Wang, D. Vu, and G. Ghosh X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites J. Mol. Biol. 373 2007 723 734
18. A.J. Fusco, D.B. Huang, D. Miller, V.Y. Wang, D. Vu, and G. Ghosh NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes EMBO Rep. 10 2009 152 159
19. L.L. Sengchanthalangsy, S. Datta, D.B. Huang, E. Anderson, E.H. Braswell, and G. Ghosh Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer J. Mol. Biol. 289 1999 1029 1040
20. D.Y. Chirgadze, M. Demydchuk, M. Becker, S. Moran, and M. Paoli Snapshot of protein structure evolution reveals conservation of functional dimerization through intertwined folding Structure 12 2004 1489 1494
21. P.A. Ganchi, S.C. Sun, W.C. Greene, and D.W. Ballard A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization Mol. Cell. Biol. 13 1993 7826 7835
22. A.S. Liss, and H.R. Bose Jr Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformation J. Virol. 76 2002 4928 4939
23. C.F. Vogel, E. Sciullo, W. Li, P. Wong, G. Lazennec, and F. Matsumura RelB, a new partner of aryl hydrocarbon receptor-mediated transcription Mol. Endocrinol. 21 2007 2941 2955
24. L.A. Puto, and J.C. Reed Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation Genes Dev. 22 2008 998 1010
25. S.J. Elsasser, H. Huang, P.W. Lewis, J.W. Chin, C.D. Allis, and D.J. Patel DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition Nature 491 2012 560 565
26. Z. Otwinowski, D. Borek, W. Majewski, and W. Minor Multiparametric scaling of diffraction intensities Acta Crystallogr., Sect. A 59 2003 228 234
27. J. Navaza Implementation of molecular replacement in AMoRe Acta Crystallogr., Sect. D: Biol. Crystallogr. 57 2001 1367 1372
28. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, and R.W. Grosse-Kunstleve Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr., Sect. D: Biol. Crystallogr. 54 1998 905 921
29. D.E. McRee XtalView/Xfit - a versatile program for manipulating atomic coordinates and electron density J. Struct. Biol. 125 1999 156 165