NF-κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes

EMBO Reports

Volumn 10, Issue 2, 2009, Pages 152-159

  Fusco, Amanda J ^a   Huang, De Bin ^a   Miller, Dustyn ^a   Wang, Vivien Ya Fan ^a   Vu, Don ^a   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; DNA; NFKB2 PROTEIN, HUMAN; RELB PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELB;

ARTICLE; BASE PAIRING; BINDING SITE; DNA BINDING; DNA PROTEIN COMPLEX; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DNA BASE COMPOSITION; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; MOUSE; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE COMPOSITION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NF-KAPPA B P52 SUBUNIT; POINT MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION, GENETIC;

EID: 59649121227     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2008.227     Document Type: Article

References (27)

1. Basak S, Kim H, Kearns J, Terganokar V, Werner S, Benedict C, Ware C, Ghosh G, Verma I, Hoffmann A (2007) A fourth IkappaB protein in the NF-kappaB signaling module. Cell 128: 369-381
2. Basak S, Shih VF, Hoffmann A (2008) Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system. Mol Cell Biol 28: 3139-3150
3. Bonizzi G et al (2004) Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J 23: 4202-4210
4. Britanova LV, Makeev VJ, Kuprash DV (2008) In vitro selection of optimal RelB/p52 DNA-binding motifs. Biochem Biophys Res Commun 365: 583-588
5. Chen F, Castranova V, Shi X, Demers LM (1999) New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45: 7-17
6. Chen FE, Huang DB, Chen YQ, Ghosh G (1998a) Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391: 410-413
7. Chen YQ, Ghosh S, Ghosh G (1998b) A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat Struct Biol 5: 67-73
8. Chen-Park FE, Huang DB, Noro B, Thanos D, Ghosh G (2002) The kappaB DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J Biol Chem 277: 24701-24708
9. Claudio E, Brown K, Siebenlist U (2006) NF-kappaB guides the survival and differentiation of developing lymphocytes. Cell Death Differ 13: 697-701
10. Cramer P, Larson CJ, Verdine GL, Muller CW (1997) Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 Å resolution. EMBO J 16: 7078-7090
11. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR (2002) The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 17: 525-535
12. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G (2008) Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem 283: 12324-12332
13. Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-S96
14. Ghosh G, van Duyne G, Ghosh S, Sigler PB (1995) Structure of NF-kappaB p50 homodimer bound to a kappaB site. Nature 373: 303-310
15. Hayden MS, West AP, Ghosh S (2006) NF-kappaB and the immune response. Oncogene 25: 6758-6780
16. Hoffmann A, Leung TH, Baltimore D (2003) Genetic analysis of NF-kappaB/ Rel transcription factors defines functional specificities. EMBO J 22: 5530-5539
17. Hoffmann A, Natoli G, Ghosh G (2006) Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25: 6706-6716
18. Huang DB, Chen YQ, Ruetsche M, Phelps CB, Ghosh G (2001) X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. Structure 9: 669-678
19. Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G (2007) X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J Mol Biol 373: 723-734
20. Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC (1995) Structure of the NF-kappaB p50 homodimer bound to DNA. Nature 373: 311-317
21. Natoli G (2006) Tuning up inflammation: How DNA sequence and chromatin organization control the induction of inflammatory genes by NF-kappaB. FEBS Lett 580: 2843-2849
22. Phelps CB, Sengchanthalangsy LL, Malek S, Ghosh G (2000) Mechanism of kappaB DNA binding by Rel/NF-kappaB dimers. J Biol Chem 275: 24392-24399
23. Saccani S, Pantano S, Natoli G (2001) Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med 193: 1351-1359
24. Senftleben U et al (2001) Activation by IKKalpha of a second, evolutionary conserved, NF-kappaB signaling pathway. Science 293: 1495-1499
25. Weih DS, Yilmaz ZB, Weih F (2001) Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J Immunol 167: 1909-1919
26. Xiao G, Harhaj EW, Sun SC (2001) NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7: 401-409
27. Yilmaz ZB, Weih DS, Sivakumar V, Weih F (2003) RelB is required for Peyer's patch development: Differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J 22: 121-130