A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of graves ophthalmopathy

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 5, 2013, Pages 2153-2159

  Turcu, Adina F ^a   Kumar, Seema ^a   Neumann, Susanne ^b   Coenen, Michael ^a   Iyer, Seethalakshmi ^a   Chiriboga, Pamela ^a   Gershengorn, Marvin C ^b   Bahn, Rebecca S ^a  

^a MAYO CLINIC   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; CYCLIC AMP; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; HYALURONIC ACID; NCGC 00229600; NCGC 00242595; PROTEIN KINASE B; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG ACTIVITY; DRUG PROTEIN BINDING; ENDOCRINE OPHTHALMOPATHY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTHYROIDISM; IMMUNOBLOTTING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THYROIDECTOMY;

ADIPOSE TISSUE, WHITE; ANTIBODIES, MONOCLONAL; CELL DEDIFFERENTIATION; CELLS, CULTURED; CYCLIC AMP; DRUG INVERSE AGONISM; EYE; FIBROBLASTS; GRAVES OPHTHALMOPATHY; HUMANS; HYALURONIC ACID; IMMUNOGLOBULINS, THYROID-STIMULATING; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; QUINAZOLINONES; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; THYROTROPIN;

EID: 84877709693     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1149     Document Type: Article

References (23)

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