A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 2, 2011, Pages 548-554

  Neumann, Susanne ^a   Eliseeva, Elena ^a   McCoy, Joshua G ^b   Napolitano, Giorgio ^c   Giuliani, Cesidio ^c   Monaco, Fabrizio ^c   Huang, Wenwei ^b   Gershengorn, Marvin C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; CYCLIC AMP; MESSENGER RNA; NCG 00229600; THYROID PEROXIDASE; THYROTROPIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTAGONIST; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE; UNCLASSIFIED DRUG;

ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE OVEREXPRESSION; GRAVES DISEASE; HORMONE BINDING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STABLE EXPRESSION; THYROID CELL; THYROID GLAND; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; UPREGULATION;

ANTIGEN-ANTIBODY REACTIONS; CELLS, CULTURED; GRAVES DISEASE; HUMANS; IMMUNOCHEMISTRY; IMMUNOGLOBULINS, THYROID-STIMULATING; IODIDE PEROXIDASE; IODINE RADIOISOTOPES; PYRIDINES; QUINAZOLINONES; RECEPTORS, THYROTROPIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 79951706011     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1935     Document Type: Article

References (15)

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