Safety issues of vitamin D supplementation

Anti-Cancer Agents in Medicinal Chemistry

Volumn 13, Issue 1, 2013, Pages 4-10

  Zittermann, Armin ^a   Prokop, Sylvana ^a   Gummert, Jan F ^a   Börgermann, Jochen ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

25 hydroxyvitamin D; Body weight; Death; Fibroblast growth factor 23; Food fortification; Hypercalcemia; Hypercalciuria; Hyperphosphatemia; Intoxication; Lowest observed adverse effect level; No observed adverse effect level; Parathyroid hormone; Safety; Sarcoidosis; Tolerable upper intake level; Toxicity; Vitamin D; Vitamin D binding protein

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; COLECALCIFEROL; ERGOCALCIFEROL; VITAMIN D;

DRUG MEGADOSE; DRUG SAFETY; HUMAN; HYPERCALCEMIA; HYPERPARATHYROIDISM; NONHUMAN; REVIEW; VITAMIN D DEFICIENCY; VITAMIN D INTOXICATION; VITAMIN SUPPLEMENTATION;

EID: 84877707997     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152013804487290     Document Type: Review

References (53)

1. Engelsen, O. The relationship between ultraviolet radiation exposure and vitamin D status. Nutrients, 2010, 2(5), 482-495.
2. Holick, M.F. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr. Opin. Endocrinol. Diabetes, 2002, 9(1), 87-98.
3. Webb, A.R.; DeCosta, B.R.; Holick, M.F. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. J. Clin. Endocrinol. Metab., 1989, 68(5), 882-887.
4. Holick, M.F. McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century. Am. J. Clin. Nutr., 1994, 60(4), 619-630.
5. Zittermann, A. The estimated benefits of vitamin D for Germany. Mol. Nutr. Food. Res., 2010, 54(8), 1164-1171.
6. Deutch, B.; Dyerberg, J.; Pedersen, H.S.; Aschlund, E.; Hansen, J.C. Traditional and modern Greenlandic food-dietary composition, nutrients and contaminants. Sci. Total. Environ., 2007, 384(1-3), 106-119.
7. Holick, M.F. Vitamin D deficiency. New. Engl. J. Med., 2007, 357(3), 266-281.
8. R. Critique of the considerations for establishing the upper tolerable intake level for vitamin D: Critical need for revisionupwards. J. Nutr., 2006, 136(4), 1117-1122.
9. Mithal, A.; Wahl, D.A.; Bonjour, J.P.; Burckhardt, P.; Dawson-Hughes, B.; Eisman, J.A.; El-Hajj Fuleihan, G.; Josse, R.G.; Lips, P.; Morales-Torres, J.; IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int., 2009, 20(11), 1807-1820.
10. Ziegler, R.; Minne, H.; Raue, F.; Paar, G.; Delling, G. Observations in vitamin D and dihydrotachysterol poisoning. Dtsch. Med. Wochenschr., 1975, 100(9), 415-423. [Article in German]
11. Lilienfeld-Toal, H.V.; Messerschmidt, W.; Sturm, B.; Ochs, H. 25-hydroxy-vitamin D levels in a patient with hypervitaminosis D. Klin. Wochenschr., 1978, 56(14), 715-717. [Article in German]
12. Koutka, P.; Chen, T.C.; Holick, M.F. Vitamin D intoxication associated with an over-the-counter supplement. New. Engl. J. Med., 2001, 345(1), 66-67.
13. Araki, T.; Holick, M.F.; Alfonso, B.D.; Charlap, E.; Romero, C.M.; Rizk, D.; Newman, L.G. Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. J. Clin. Endocrinol. Metab., 2011, 96(12), 3603-3608.
14. Jacobus, C.H.; Holick, M.F.; Shao, Q.; Chen, T.C.; Holm, I.A.; Kolodny, J.M.; Fuleihan, G.E.; Seely, E.W. Hypervitaminosis D associated with drinking milk. New. Engl. J. Med., 1992, 30(18), 1173-1177.
15. Blank, S.; Scanlon, K.S.; Sinks, T.H.; Lett, S.; Falk, H. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. Am. J. Public Health, 1995, 85(5), 656-659.
16. Chesney, R.W. Vitamin D: Can an upper limit be defined? J. Nutr., 1989, 119(12 Suppl), 1825-8.
17. Markestad, T.; Hesse, V.; Siebenhuner, M.; Jahreis, G.; Aksnes, L.; Plenert, W.; Aarskog, D. Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus. Am. J. Clin. Nutr., 1987, 46(4), 652-658.
18. Kobylinski, S.; Häfer, B.; Kohde, G. [Correlative pathologic studies on the role of vitamin D in vascular calcinosis in childhood]. Zentralbl. Allg. Pathol., 1984, 129(2), 137-147. Article in German
19. Deluca, H.F.; Prahl, J.M.; Plum, L.A. 1,25-Dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D. Arch. Biochem. Biophys., 2011, 505(2), 226-230.
20. IOM (Institute of Medicine). Dietary Reference Intakes for Calcium and Vitamin D. The National Academies Press: Washington, DC, 2011
21. Price, P.A.; Buckley, J.R.; Williamson, M.K. The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats. J. Nutr., 2001, 131(11), 2910-2915.
22. Jones, G. Pharmacokinetics of vitamin D toxicity. Am. J. Clin. Nutr., 2008, 88(2), 582S-586S.
23. Tuohimaa, P. Vitamin D and aging. J. Steroid. Biochem. Mol. Biol., 2009, 114(1-2), 78-84.
24. Sharma, O.P. Vitamin D, calcium, and sarcoidosis. Chest., 1996, 109(2), 535-539.
25. Plum, L.A.; DeLuca, H.F. Vitamin D, disease and therapeutic opportunities. Nature Rev. Drug. Discov., 2010, 9(12), 941-955.
26. Hathcock, J.N.; Shao, A.; Vieth, R.; Heaney, R. Risk assessment for vitamin D. Am. J. Clin. Nutr., 2007, 85(1), 6-18.
27. Heaney, R.P.; Davies, K.M.; Chen, T.C.; Holick, M.F.; Barger-Lux, M.J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am. J. Clin. Nutr., 2003, 77(1), 204-210.
28. Barger-Lux, M.J.; Heaney, R.P. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J. Clin. Endocrinol. Metab., 2002, 87(11), 4952-4956.
29. Ross, A.C.; Manson, J.E.; Abrams, S.A.; Aloia, J.F.; Brannon, P.M.; Clinton, S.K.; Durazo-Arvizu, R.A.; Gallagher, J.C.; Gallo, R.L.; Jones, G.; Kovacs, C.S.; Mayne, S.T.; Rosen, C.J.; Shapses, S.A. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J. Clin. Endocrinol. Metab., 2011, 96(1), 53-58.
30. Hyppönen, E.; Berry, D.J.; Wjst, M.; Power, C. Serum 25-hydroxyvitamin D and IgE-a significant but nonlinear relationship. Allergy, 2009, 64(4), 613-620.
31. Zittermann, A.; Börgermann, J.; Gummert, J.F.; Pilz, S. Future directions in cardiovascular research. Nutr. Metab. Cardiovasc. Dis., 2012, 22(7), 541-546.
32. Sanders, K.M.; Stuart, A.L.; Williamson, E.J.; Simpson, J.A.; Kotowicz, M.A.; Young, D.; Nicholson, G.C. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA, 2010, 303(18), 1815-1822.
33. Rossini, M.; Gatti, D.; Viapiana, O.; Fracassi, E.; Idolazzi, L.; Zanoni, S.; Adami, S. Short-Term Effects on Bone Turnover Markers of a Single High Dose of Oral Vitamin D3. J. Clin. Endocrinol. Metab., 2012, 97(4), E622-E626.
34. Trivedi, D.P.; Doll, R.; Khaw, K.T. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ, 2003, 326(7387), 469.
35. Vieth, R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr., 1999, 69(5), 842-856.
36. Maalouf, J.; Nabulsi, M.; Vieth, R.; Kimball, S.; El-Rassi, R.; Mahfoud, Z.; El-Hajj Fuleihan, G. Short-and long-term safety of weekly high-dose vitamin D3 supplementation in school children. J. Clin. Endocrinol. Metab., 2008, 93(7), 2693-2701.
37. Sneve, M.; Figenschau, Y.; Jorde, R. Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects. Eur. J. Endocrinol., 2008, 159(6), 675-684.
38. Zittermann, A.; Frisch, S.; Berthold, H.K.; Götting, C.; Kuhn, J.; Kleesiek, K.; Stehle, P.; Koertke, H.; Koerfer, R. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am. J. Clin. Nutr., 2009, 89(5), 1321-1327.
39. Mocanu, V.; Stitt, P.A.; Costan, A.R.; Voroniuc, O.; Zbranca, E.; Luca, V.; Vieth, R. Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving. Am. J. Clin. Nutr., 2009, 89(4), 1132-1137.
40. von Hurst, P.R.; Stonehouse, W.; Coad, J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial. Br. J. Nutr., 2010, 103(4), 549-555.
41. Bischoff-Ferrari, H.A.; Giovannucci, E.; Willett, W.C.; Dietrich, T.; Dawson-Hughes, B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr., 2006, 84(1), 18-28.
42. Bischoff-Ferrari, H.A.; Shao, A.; Dawson-Hughes, B.; Hathcock, J.; Giovannucci, E.; Willett, W.C. Benefit-risk assessment of vitamin D supplementation. Osteoporos. Int., 2010, 21(7), 1121-1132.
43. Zittermann, A.; Iodice, S.; Pilz, S.; Grant, W.B.; Bagnardi, V.; Gandini, S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am. J. Clin. Nutr., 2012, 95(1), 91-100.
44. Zittermann, A. Serum 25-hydroxyvitamin D response to oral vitamin D intake in children. Am. J. Clin. Nutr., 2003, 78(3), 496-497.
45. Schleithoff, S.S.; Zittermann, A.; Tenderich, G.; Berthold, H.K.; Stehle, P.; Koerfer, R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a doubleblind, randomized, placebo-controlled trial. Am. J. Clin. Nutr., 2006, 83(4), 754-759.
46. Wagner, C.L.; Howard, C.; Hulsey, T.C.; Lawrence, R.A.; Taylor, S.N.; Will, H.; Ebeling, M.; Hutson, J.; Hollis, B.W. Circulating 25-hydroxyvitamin d levels in fully breastfed infants on oral vitamin d supplementation. Int. J. Endocrinol., 2010, 2010, 235035.
47. Aloia, J.F.; Patel, M.; Dimaano, R.; Li-Ng, M.; Talwar, S.A.; Mikhail, M.; Pollack, S.; Yeh, J.K. Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. Am. J. Clin. Nutr., 2008, 87(6), 1952-1958.
48. Lips, P.; Duong, T.; Oleksik, A.; Black, D.; Cummings, S.; Cox, D.; Nickelsen, T. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J. Clin. Endocrinol. Metab., 2001, 86(3), 1212-1221.
49. Houghton, L.A.; Vieth, R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am. J. Clin. Nutr., 2006, 84(4), 694-697.
50. Vieth, R. The pharmacology of vitamin D, including fortification strategies. In: Vitamin D. Second edition. Feldman D, Pike JW, Glorieux FH (Eds). Elsevier Academic Press, Amsterdam, 2005, pp. 995-1015.
51. Bischoff-Ferrari, H.A.; Dawson-Hughes, B.; Stöcklin, E.; Sidelnikov, E.; Willett, W.C.; Orav, E.J.; Stähelin, H.B.; Wolfram, S.; Jetter, A.; Schwager, J.; Henschkowski, J.; von Eckardstein, A.; Egli, A. Oral supplementation with 25(OH)D(3) versus vitamin D(3): effects on 25(OH)D levels, lower extremity function, blood pressure and markers of innate immunity. J. Bone. Miner. Res., 2011, doi: 10.1002/jbmr.551. [Epub ahead of print]
52. Ish-Shalom, S.; Segal, E.; Salganik, T.; Raz, B.; Bromberg, I.L.; Vieth, R. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J. Clin Endocrinol. Metab., 2008, 93(9), 3430-3405.
53. van Groningen, L.; Opdenoordt, S.; van Sorge, A.; Telting, D.; Giesen, A.; de Boer, H. Cholecalciferol loading dose guideline for vitamin D-deficient adults. Eur. J. Endocrinol. 2010, 162(4), 805-811.