-
1
-
-
84862849188
-
Pre-exposure prophylaxis for HIV prevention: How to predict success
-
Kashuba, A. D.; Patterson, K. B.; Dumond, J. B.; Cohen, M. S. Pre-exposure prophylaxis for HIV prevention: how to predict success Lancet 2012, 379, 2409-2411
-
(2012)
Lancet
, vol.379
, pp. 2409-2411
-
-
Kashuba, A.D.1
Patterson, K.B.2
Dumond, J.B.3
Cohen, M.S.4
-
2
-
-
80051633217
-
Prevention of HIV-1 infection with early antiretroviral therapy
-
Cohen, M. S.; Chen, Y. Q.; McCauley, M.; Gamble, T.; Hosseinipour, M. C.; Kumarasamy, N.; Hakim, J. G.; Kumwenda, J.; Grinsztejn, B.; Pilotto, J. H.; Godbole, S. V.; Mehendale, S.; Chariyalertsak, S.; Santos, B. R.; Mayer, K. H.; Hoffman, I. F.; Eshleman, S. H.; Piwowar-Manning, E.; Wang, L.; Makhema, J.; Mills, L. A.; De Bruyn, G.; Sanne, I.; Eron, J.; Gallant, J.; Havlir, D.; Swindells, S.; Ribaudo, H.; Elharrar, V.; Burns, D.; Taha, T. E.; Nielsen-Saines, K.; Celentano, D.; Essex, M.; Fleming, T. R. Prevention of HIV-1 infection with early antiretroviral therapy N. Engl. J. Med. 2011, 365, 493-505
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 493-505
-
-
Cohen, M.S.1
Chen, Y.Q.2
McCauley, M.3
Gamble, T.4
Hosseinipour, M.C.5
Kumarasamy, N.6
Hakim, J.G.7
Kumwenda, J.8
Grinsztejn, B.9
Pilotto, J.H.10
Godbole, S.V.11
Mehendale, S.12
Chariyalertsak, S.13
Santos, B.R.14
Mayer, K.H.15
Hoffman, I.F.16
Eshleman, S.H.17
Piwowar-Manning, E.18
Wang, L.19
Makhema, J.20
Mills, L.A.21
De Bruyn, G.22
Sanne, I.23
Eron, J.24
Gallant, J.25
Havlir, D.26
Swindells, S.27
Ribaudo, H.28
Elharrar, V.29
Burns, D.30
Taha, T.E.31
Nielsen-Saines, K.32
Celentano, D.33
Essex, M.34
Fleming, T.R.35
more..
-
3
-
-
2342595186
-
Nonnucleoside inhibitors of HIV-1 reverse transcriptase: From the biology of reverse transcription to molecular design
-
Tronchet, J. M.; Seman, M. Nonnucleoside inhibitors of HIV-1 reverse transcriptase: from the biology of reverse transcription to molecular design Curr. Top. Med. Chem. 2003, 3, 1496-1511
-
(2003)
Curr. Top. Med. Chem.
, vol.3
, pp. 1496-1511
-
-
Tronchet, J.M.1
Seman, M.2
-
4
-
-
3042760870
-
Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors
-
Tarby, C. M. Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors Curr. Top. Med. Chem. 2004, 4, 1045-1057
-
(2004)
Curr. Top. Med. Chem.
, vol.4
, pp. 1045-1057
-
-
Tarby, C.M.1
-
5
-
-
0028847410
-
Novel Non-Nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 5. 4-Substituted and 2,4-Disubstituted Analogs of Nevirapine
-
Kelly, T. A.; Proudfoot, J. R.; McNeil, D. W.; Patel, U. R.; David, E.; Hargrave, D. K.; Grob, P. M.; Cardozo, M.; Agarwal, A.; Adam, J. Novel Non-Nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 5. 4-Substituted and 2,4-Disubstituted Analogs of Nevirapine J. Med. Chem. 1995, 38, 4839-4847
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4839-4847
-
-
Kelly, T.A.1
Proudfoot, J.R.2
McNeil, D.W.3
Patel, U.R.4
David, E.5
Hargrave, D.K.6
Grob, P.M.7
Cardozo, M.8
Agarwal, A.9
Adam, J.10
-
6
-
-
9544229686
-
Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors
-
Romero, D. L.; Olmsted, R. A.; Poel, T. J.; Morge, R. A.; Biles, C.; Keiser, B. J.; Kopta, L. A.; Friis, J. M.; Hosley, J. D.; Stefanski, K. J.; Wishka, D. G.; Evans, D. B.; Morris, J.; Stehle, R. G.; Sharma, S. K.; Yagi, Y.; Voorman, R. L.; Adams, W. J.; Tarpley, W. G.; Thomas, R. C. Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino) piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors J. Med. Chem. 1996, 39, 3769-3789
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3769-3789
-
-
Romero, D.L.1
Olmsted, R.A.2
Poel, T.J.3
Morge, R.A.4
Biles, C.5
Keiser, B.J.6
Kopta, L.A.7
Friis, J.M.8
Hosley, J.D.9
Stefanski, K.J.10
Wishka, D.G.11
Evans, D.B.12
Morris, J.13
Stehle, R.G.14
Sharma, S.K.15
Yagi, Y.16
Voorman, R.L.17
Adams, W.J.18
Tarpley, W.G.19
Thomas, R.C.20
more..
-
7
-
-
2342620790
-
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
-
Das, K.; Clark, A. D.; Lewi, P. J.; Heeres, J.; de Jonge, M. R.; Koymans, L. M. H.; Vinkers, H. M.; Daeyaert, F.; Ludovici, D. W.; Kukla, M. J.; Corte, B. D.; Kavash, R. W.; Ho, C. Y.; Ye, H.; Lichtenstein, M. A.; Andries, K.; Pauwels, R.; de Béthune, M. P.; Boyer, P. L.; Clark, P.; Hughes, S. H.; Janssen, Paul, A. J.; Arnold, E. Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants J. Med. Chem. 2004, 47, 2550-2560
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2550-2560
-
-
Das, K.1
Clark, A.D.2
Lewi, P.J.3
Heeres, J.4
De Jonge, M.R.5
Koymans, L.M.H.6
Vinkers, H.M.7
Daeyaert, F.8
Ludovici, D.W.9
Kukla, M.J.10
Corte, B.D.11
Kavash, R.W.12
Ho, C.Y.13
Ye, H.14
Lichtenstein, M.A.15
Andries, K.16
Pauwels, R.17
De Béthune, M.P.18
Boyer, P.L.19
Clark, P.20
Hughes, S.H.21
Janssen Paul, A.J.22
Arnold, E.23
more..
-
8
-
-
15444380338
-
From 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk ](1,4)benzodiazepin-2(1 H)-one (TIBO) to Etravirine (TMC125): Fifteen Years of Research on Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
-
De Corte, B. L. From 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk ](1,4)benzodiazepin-2(1 H)-one (TIBO) to Etravirine (TMC125): Fifteen Years of Research on Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase J. Med. Chem. 2005, 48, 1689-1696
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1689-1696
-
-
De Corte, B.L.1
-
9
-
-
77952724079
-
Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design
-
Lansdon, E. B.; Brendza, K. M.; Hung, M.; Wang, R.; Mukund, S.; Jin, D.; Birkus, G.; Kutty, N.; Xiaohong, Liu. Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design J. Med. Chem. 2010, 53, 4295-4299
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4295-4299
-
-
Lansdon, E.B.1
Brendza, K.M.2
Hung, M.3
Wang, R.4
Mukund, S.5
Jin, D.6
Birkus, G.7
Kutty, N.8
Xiaohong, Liu.9
-
10
-
-
84859231900
-
2011 update of the drug resistance mutations in HIV-1
-
Johnson, V. A.; Calvez, V.; Gunthard, H. F.; Paredes, R.; Pillay, D.; Shafer, R.; Wensing, A. M.; Richman, D. D. 2011 update of the drug resistance mutations in HIV-1 Top. Antiviral Med. 2011, 19, 156-164
-
(2011)
Top. Antiviral Med.
, vol.19
, pp. 156-164
-
-
Johnson, V.A.1
Calvez, V.2
Gunthard, H.F.3
Paredes, R.4
Pillay, D.5
Shafer, R.6
Wensing, A.M.7
Richman, D.D.8
-
11
-
-
0028947588
-
High resolution structures of HIV-1 RT from four RT-inhibitor complexes
-
Ren, J.; Esnouf, R.; Garman, E.; Somers, D.; Ross, C.; Kirby, I.; Keeling, J.; Darby, G.; Jones, Y.; Stuart, D.; Et, A. High resolution structures of HIV-1 RT from four RT-inhibitor complexes Nature Struct. Biol. 1995, 2, 293-302
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 293-302
-
-
Ren, J.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
Kirby, I.6
Keeling, J.7
Darby, G.8
Jones, Y.9
Stuart, D.10
Et, A.11
-
12
-
-
9644291579
-
TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1
-
Andries, K.; Azijn, H.; Thielemans, T.; Ludovici, D.; Kukla, M.; Heeres, J.; Janssen, P.; De Corte, B.; Vingerhoets, J.; Pauwels, R.; de Bethune, M. P. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1 Antimicrob. Agents Chemother. 2004, 48, 4680-4686
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4680-4686
-
-
Andries, K.1
Azijn, H.2
Thielemans, T.3
Ludovici, D.4
Kukla, M.5
Heeres, J.6
Janssen, P.7
De Corte, B.8
Vingerhoets, J.9
Pauwels, R.10
De Bethune, M.P.11
-
13
-
-
75749118495
-
TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1
-
Azijn, H.; Tirry, I.; Vingerhoets, J.; de Bethune, M. P.; Kraus, G.; Boven, K.; Jochmans, D.; Van Craenenbroeck, E.; Picchio, G.; Rimsky, L. T. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1 Antimicrob. Agents Chemother. 2010, 54, 718-727
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 718-727
-
-
Azijn, H.1
Tirry, I.2
Vingerhoets, J.3
De Bethune, M.P.4
Kraus, G.5
Boven, K.6
Jochmans, D.7
Van Craenenbroeck, E.8
Picchio, G.9
Rimsky, L.T.10
-
14
-
-
1442355578
-
HIV drug resistance
-
reference 11
-
Clavel, F.; Hance, A. J. HIV drug resistance N. Engl. J. Med. 2004, 350, 1023-1035 reference 11.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 1023-1035
-
-
Clavel, F.1
Hance, A.J.2
-
15
-
-
84866325636
-
Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors
-
Asahchop, E. L.; Wainberg, M. A.; Sloan, R. D.; Tremblay, C. L. Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors Antimicrob. Agents Chemother. 2012, 56, 5000-5008
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5000-5008
-
-
Asahchop, E.L.1
Wainberg, M.A.2
Sloan, R.D.3
Tremblay, C.L.4
-
16
-
-
33847034809
-
Persistence of K103N-containing HIV-1 variants after single-dose nevirapine for prevention of HIV-1 mother-to-child transmission
-
Flys, T. S.; Donnell, D.; Mwatha, A.; Nakabiito, C.; Musoke, P.; Mmiro, F.; Jackson, J. B.; Guay, L. A.; Eshleman, S. H. Persistence of K103N-containing HIV-1 variants after single-dose nevirapine for prevention of HIV-1 mother-to-child transmission J. Infect. Dis. 2007, 195, 711-715
-
(2007)
J. Infect. Dis.
, vol.195
, pp. 711-715
-
-
Flys, T.S.1
Donnell, D.2
Mwatha, A.3
Nakabiito, C.4
Musoke, P.5
Mmiro, F.6
Jackson, J.B.7
Guay, L.A.8
Eshleman, S.H.9
-
17
-
-
80051829496
-
Development of antiretroviral drug resistance
-
Wainberg, M. A.; Zaharatos, G. J.; Brenner, B. G. Development of antiretroviral drug resistance N. Engl. J. Med. 2011, 365, 637-646
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 637-646
-
-
Wainberg, M.A.1
Zaharatos, G.J.2
Brenner, B.G.3
-
18
-
-
0028271687
-
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
-
Smerdon, S. J.; Jager, J.; Wang, J.; Kohlstaedt, L. A.; Chirino, A. J.; Friedman, J. M.; Rice, P. A.; Steitz, T. A. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1 Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 3911-3915
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 3911-3915
-
-
Smerdon, S.J.1
Jager, J.2
Wang, J.3
Kohlstaedt, L.A.4
Chirino, A.J.5
Friedman, J.M.6
Rice, P.A.7
Steitz, T.A.8
-
19
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence, R. A.; Kati, W. M.; Anderson, K. S.; Johnson, K. A. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors Science 1995, 267, 988-993
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
20
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
Esnouf, R.; Ren, J.; Ross, C.; Jones, Y.; Stammers, D.; Stuart, D. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors Nature Struct. Biol. 1995, 2, 303-308
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
21
-
-
0026489556
-
Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1 H)-one
-
Saari, W. S.; Wai, J. S.; Fisher, T. E.; Thomas, C. M.; Hoffman, J. M.; Clarence S. Rooney, C. S.; Smith, A. M.; Jones, J. H.; Bamberger, D. J.; Goldman, M. E.; OBrien, J. A.; Nunberg, J. H.; Quintero, J. C.; Schleif, W. A.; Emini, E. A.; Anderson, P. S. Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1 H)-one J. Med. Chem. 1992, 35, 3192-3802
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3192-3802
-
-
Saari, W.S.1
Wai, J.S.2
Fisher, T.E.3
Thomas, C.M.4
Hoffman, J.M.5
Clarence Rooney, S.C.S.6
Smith, A.M.7
Jones, J.H.8
Bamberger, D.J.9
Goldman, M.E.10
Obrien, J.A.11
Nunberg, J.H.12
Quintero, J.C.13
Schleif, W.A.14
Emini, E.A.15
Anderson, P.S.16
-
22
-
-
0029976422
-
Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors
-
ref 23
-
Hopkins, A. L.; Ren, J.; Esnouf, R. M.; Willcox, B. E.; Jones, E. Y.; Ross, C.; Miyasaka, T.; Walker, R. T.; Tanaka, H.; Stammers, D. K.; Stuart, D. I. Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors J. Med. Chem. 1996, 39, 1589-1600 ref 23.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1589-1600
-
-
Hopkins, A.L.1
Ren, J.2
Esnouf, R.M.3
Willcox, B.E.4
Jones, E.Y.5
Ross, C.6
Miyasaka, T.7
Walker, R.T.8
Tanaka, H.9
Stammers, D.K.10
Stuart, D.I.11
-
23
-
-
84863290357
-
Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl) methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile
-
Wang, X.; Zhang, J.; Huang, Y.; Wang, R.; Zhang, L.; Qiao, K.; Li, L.; Liu, C.; Ouyang, Y.; Xu, W.; Zhang, Z.; Zhang, L.; Shao, Y.; Jiang, S.; Ma, L.; Liu, J. Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/ alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile J. Med. Chem. 2012, 55, 2242-2250
-
(2012)
J. Med. Chem.
, vol.55
, pp. 2242-2250
-
-
Wang, X.1
Zhang, J.2
Huang, Y.3
Wang, R.4
Zhang, L.5
Qiao, K.6
Li, L.7
Liu, C.8
Ouyang, Y.9
Xu, W.10
Zhang, Z.11
Zhang, L.12
Shao, Y.13
Jiang, S.14
Ma, L.15
Liu, J.16
-
24
-
-
33846378472
-
Structure-activity relationship in the 3-iodo-4-phenoxy pyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity
-
Benjahad, A.; Oumouch, S.; Guillemont, J.; Pasquier, E.; Mabire, D.; Andries, K.; Chi Hung Nguyena, C. H.; Griersona, D. S. Structure-activity relationship in the 3-iodo-4-phenoxy pyridinone (IOPY) series: the nature of the C-3 substituent on anti-HIV activity Bioorg. Med. Chem. Lett. 2007, 17, 712-716
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 712-716
-
-
Benjahad, A.1
Oumouch, S.2
Guillemont, J.3
Pasquier, E.4
Mabire, D.5
Andries, K.6
Chi Hung Nguyena, C.H.7
Griersona, D.S.8
-
25
-
-
9744258219
-
Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Das, K.; Lewi, P. J.; Hughes, S. H.; Arnold, E. Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors Prog. Biophys. Mol. Biol. 2005, 88, 209-231
-
(2005)
Prog. Biophys. Mol. Biol.
, vol.88
, pp. 209-231
-
-
Das, K.1
Lewi, P.J.2
Hughes, S.H.3
Arnold, E.4
-
26
-
-
0028877325
-
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors
-
Dolle, V.; Fan, E.; Nguyen, C. H.; Aubertin, A. M.; Kirn, A.; Andreola, M. L.; Jamieson, G.; Tarrago-Litvak, L.; Bisagni, E. A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors J. Med. Chem. 1995, 38, 4679-4686
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4679-4686
-
-
Dolle, V.1
Fan, E.2
Nguyen, C.H.3
Aubertin, A.M.4
Kirn, A.5
Andreola, M.L.6
Jamieson, G.7
Tarrago-Litvak, L.8
Bisagni, E.9
-
27
-
-
20144370682
-
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1 H)-ones: In vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains
-
Benjahad, A.; Croisy, M.; Monneret, C.; Bisagni, E.; Mabire, D.; Coupa, S.; Poncelet, A.; Csoka, I.; Guillemont, J.; Meyer, C.; Andries, K.; Pauwels, R.; de Bethune, M. P.; Himmel, D. M.; Das, K.; Arnold, E.; Nguyen, C. H.; Grierson, D. S. 4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1 H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains J. Med. Chem. 2005, 48, 1948-1964
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1948-1964
-
-
Benjahad, A.1
Croisy, M.2
Monneret, C.3
Bisagni, E.4
Mabire, D.5
Coupa, S.6
Poncelet, A.7
Csoka, I.8
Guillemont, J.9
Meyer, C.10
Andries, K.11
Pauwels, R.12
De Bethune, M.P.13
Himmel, D.M.14
Das, K.15
Arnold, E.16
Nguyen, C.H.17
Grierson, D.S.18
-
28
-
-
67549128954
-
New Pyridinone Derivatives as Potent HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors
-
Van, K. L.; Cauvin, C.; de Walque, S.; Georges, B.; Boland, S.; Martinelli, V.; Demonté, D.; Durant, F.; Hevesi, L.; Van Lint, C. New Pyridinone Derivatives as Potent HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors J. Med. Chem. 2009, 52, 3636-3643
-
(2009)
J. Med. Chem.
, vol.52
, pp. 3636-3643
-
-
Van, K.L.1
Cauvin, C.2
De Walque, S.3
Georges, B.4
Boland, S.5
Martinelli, V.6
Demonté, D.7
Durant, F.8
Hevesi, L.9
Van Lint, C.10
-
29
-
-
35148883143
-
The design and synthesis of N-1-alkylated-5-aminoarylalkyl-substituted-6- methyluracils as potential non-nucleoside HIV-1 RT inhibitors
-
Lu, X.; Chen, Y.; Guo, Y.; Liu, Z.; Shi, Y.; Xu, Y.; Wang, X.; Zhang, Z.; Liu, J. The design and synthesis of N-1-alkylated-5-aminoarylalkyl-substituted- 6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors Bioorg. Med. Chem. 2007, 15, 7399-7407
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 7399-7407
-
-
Lu, X.1
Chen, Y.2
Guo, Y.3
Liu, Z.4
Shi, Y.5
Xu, Y.6
Wang, X.7
Zhang, Z.8
Liu, J.9
-
30
-
-
77951206884
-
Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
-
Qin, H.; Liu, C.; Guo, Y.; Wang, R.; Zhang, J.; Ma, L.; Zhang, Z.; Wang, X.; Cui, Y.; Liu, J. Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors Bioorg. Med. Chem. 2010, 18, 3231-3237
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 3231-3237
-
-
Qin, H.1
Liu, C.2
Guo, Y.3
Wang, R.4
Zhang, J.5
Ma, L.6
Zhang, Z.7
Wang, X.8
Cui, Y.9
Liu, J.10
-
31
-
-
0031552362
-
Development and validation of a genetic algorithm for flexible docking
-
Jones, G.; Willett, P.; Glen, R. C.; Leach, A. R.; Taylor, R. Development and validation of a genetic algorithm for flexible docking J. Mol. Biol. 1997, 267, 727-748
-
(1997)
J. Mol. Biol.
, vol.267
, pp. 727-748
-
-
Jones, G.1
Willett, P.2
Glen, R.C.3
Leach, A.R.4
Taylor, R.5
-
32
-
-
0033574492
-
A Pyrazole to Furan Rearrangement. Thermolysis of 5-Azido-4- formylpyrazoles
-
Svenstrup, N.; Simonsen, K. B.; Thorup, N.; Brodersen, J.; Dehaen, W.; Becher, J. A Pyrazole to Furan Rearrangement. Thermolysis of 5-Azido-4-formylpyrazoles J. Org. Chem. 1999, 64, 2814-2820
-
(1999)
J. Org. Chem.
, vol.64
, pp. 2814-2820
-
-
Svenstrup, N.1
Simonsen, K.B.2
Thorup, N.3
Brodersen, J.4
Dehaen, W.5
Becher, J.6
-
33
-
-
51849105600
-
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: Synthesis, X-ray crystallographic analysis, and biological activities
-
Kim, K. S.; Zhang, L.; Schmidt, R.; Cai, Z. W.; Wei, D.; Williams, D. K.; Lombardo, L. J.; Trainor, G. L.; Xie, D.; Zhang, Y.; An, Y.; Sack, J. S.; Tokarski, J. S.; Darienzo, C.; Kamath, A.; Marathe, P.; Zhang, Y.; Lippy, J.; Jeyaseelan, R. S.; Wautlet, B.; Henley, B.; Gullo-Brown, J.; Manne, V.; Hunt, J. T.; Fargnoli, J.; Borzilleri, R. M. Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities J. Med. Chem. 2008, 51, 5330-5341
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5330-5341
-
-
Kim, K.S.1
Zhang, L.2
Schmidt, R.3
Cai, Z.W.4
Wei, D.5
Williams, D.K.6
Lombardo, L.J.7
Trainor, G.L.8
Xie, D.9
Zhang, Y.10
An, Y.11
Sack, J.S.12
Tokarski, J.S.13
Darienzo, C.14
Kamath, A.15
Marathe, P.16
Zhang, Y.17
Lippy, J.18
Jeyaseelan, R.S.19
Wautlet, B.20
Henley, B.21
Gullo-Brown, J.22
Manne, V.23
Hunt, J.T.24
Fargnoli, J.25
Borzilleri, R.M.26
more..
-
34
-
-
33744804003
-
Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe
-
Terai, T.; Kikuchi, K.; Iwasawa, S. Y.; Kawabe, T.; Hirata, Y.; Urano, Y.; Nagano, T. Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe J. Am. Chem. Soc. 2006, 128, 6938-6946
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 6938-6946
-
-
Terai, T.1
Kikuchi, K.2
Iwasawa, S.Y.3
Kawabe, T.4
Hirata, Y.5
Urano, Y.6
Nagano, T.7
-
35
-
-
0037319206
-
Microwave-Assisted Solution-Phase Synthesis of 1,4,5-Trisubstituted Pyrazoles
-
Giacomelli, G.; Porcheddu, A.; Salaris, M.; Taddei, M. Microwave-Assisted Solution-Phase Synthesis of 1,4,5-Trisubstituted Pyrazoles Eur. J. Org. Chem. 2003, 3, 537-541
-
(2003)
Eur. J. Org. Chem.
, vol.3
, pp. 537-541
-
-
Giacomelli, G.1
Porcheddu, A.2
Salaris, M.3
Taddei, M.4
-
36
-
-
84877702089
-
Preparation of 2(1 H)-pyridinone derivatives as HIV-1 reverse transcriptase inhibitors
-
CN 201010515280.1
-
Li, A. M.; Wang, X. W.; Ma, L. Y.; Shao, Y. M.; Liu, J. Y.; Preparation of 2(1 H)-pyridinone derivatives as HIV-1 reverse transcriptase inhibitors. Faming Zhuanli Shenqing. CN 201010515280.1, 2010.
-
(2010)
Faming Zhuanli Shenqing
-
-
Li, A.M.1
Wang, X.W.2
Ma, L.Y.3
Shao, Y.M.4
Liu, J.Y.5
-
37
-
-
7244253012
-
N-Substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion
-
Jiang, S.; Lu, H.; Liu, S.; Zhao, Q.; He, Y.; Debnath, A. K. N-Substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion Antimicrob. Agents Chemother. 2004, 48, 4349-4359
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4349-4359
-
-
Jiang, S.1
Lu, H.2
Liu, S.3
Zhao, Q.4
He, Y.5
Debnath, A.K.6
-
38
-
-
76149120388
-
Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization and Multithreading
-
Trott, O.; Olson, A. J. Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization and Multithreading J. Comput. Chem. 2010, 31, 455-461
-
(2010)
J. Comput. Chem.
, vol.31
, pp. 455-461
-
-
Trott, O.1
Olson, A.J.2
-
39
-
-
0033954256
-
The Protein Data Bank
-
Berman, H. M. The Protein Data Bank Nucleic Acids Res. 2000, 28 (1) 235-242
-
(2000)
Nucleic Acids Res.
, vol.28
, Issue.1
, pp. 235-242
-
-
Berman, H.M.1
|