Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 1843-1854

  Li, Man ^a   Jiang, Yuhong ^a   Xu, Chaoqun ^b   Zhang, Zhirong ^a   Sun, Xun ^a  

^a SICHUAN UNIVERSITY   (China)

^b Sichuan Academy of Chinese Medicine Sciences   (China)

Author keywords

DNA delivery; Heterologous vaccination; Human immunodeficiency virus; Immune response; Mannosylated polyethyleneimine

Indexed keywords

ADENOVIRUS VECTOR; DNA VACCINE; GAG PROTEIN; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 4; MANNOSYLATED POLYETHYLENEIMINE; PLASMID DNA; PRIMER DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL STRAIN; CELL STRAIN DC 2.4; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA TRANSFECTION; FEMALE; GAMMA INTERFERON BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; INTERLEUKIN 4 BLOOD LEVEL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SPLEEN CELL; TARGET CELL; VACCINATION; VACCINE PRODUCTION;

DNA DELIVERY; HETEROLOGOUS VACCINATION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MANNOSYLATED POLYETHYLENEIMINE;

ADENOVIRIDAE; ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; ANTIBODIES, VIRAL; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; INTERFERON-GAMMA; INTERLEUKIN-4; MANNOSE; MICE; MICE, INBRED BALB C; POLYETHYLENEIMINE; T-LYMPHOCYTES; TRANSFECTION; VACCINES, DNA;

EID: 84877704918     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S43827     Document Type: Article

References (39)

1. Fauci AS, Johnston MI, Dieffenbach CW, et al. HIV vaccine research: the way forward. Science. 2008;321(5888):530-532.
2. Duerr A, Wasserheit JN, Corey L. HIV vaccines: new frontiers in vaccine development. Clin Infect Dis. 2006;43(4):500-511.
3. Nabel GJ. HIV vaccine strategies. Vaccine. 2002;20(15):1945-1947.
4. Casimiro DR, Chen L, Fu TM, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol. 2003;77(11):6305-6313.
5. Sha BE, Onorato M, Bartlett JA, et al. Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12. AIDS. 2004;18(8):1203-1216.
6. Lo CY, Wu Z, Misplon JA, et al. Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: cold-adapted vaccine versus DNA prime-adenovirus boost strategies. Vaccine. 2008;26(17): 2062-2072.
7. + T-cell responses to hepatitis C virus core and E2 by a DNA prime-adenovirus boost. Vaccine. 2003;21(31): 4555-4564.
8. Qiu C, Xu JQ. HIV-1/AIDS vaccine development: are we in the darkness. Chin Med J (Engl). 2008;121(10):939-945.
9. + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med. 1998;4(4):397-402.
10. Kim HD, Jin JJ, Maxwell JA, Fukuchi KI. Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease. Immunol Lett. 2007;112(1):30-38.
11. Donnelly JJ, Ulmer JB, Liu MA. DNA vaccines. Life Sci. 1997;60(3): 163-172.
12. Mennuni C, Calvaruso F, Facciabene A, et al. Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous primeboost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA. Int J Cancer. 2005;117(3):444-455.
13. Forns X, Payette PJ, Ma X, et al. Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV. Hepatology. 2000;32(3):618-625.
14. Jiang HL, Kang ML, Quan JS, et al. The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization. Biomaterials. 2008;29(12):1931-1939.
15. Kawakami S, Sato A, Nishikawa M, Yamashita F, Hashida M. Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes. Gene Ther. 2000;7(4):292-299.
16. Howard KA, Alpar HO. The development of polyplex-based DNA vaccines. J Drug Target. 2002;10(2):143-151.
17. Sun X, Chen SM, Han J, Zhang Z. Mannosylated biodegradable polyethyleneimine for targeted DNA delivery to dendritic cells. Int J Nanomedicine. 2012;7:2929-2942.
18. Wu L, Kong WP, Nabel GJ. Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human immunodeficiency virus Env and Gag immunogens. J Virol. 2005;79(13): 8024-8031.
19. + T-cell responses in mice. J Virol. 2007;81(21):11840-11849.
20. Wherry EJ, Teichgräber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003;4(3):225-234.
21. Godbey WT, Wu KK, Mikos AG. Poly(ethylenimine) and its role in gene delivery. J Control Release. 1999;60(2-3):149-160.
22. Thomas M, Klibanov AM. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A. 2002;99(23):14640-14645.
23. Kukowska-Latallo JF, Raczka E, Quintana A, Chen C, Rymaszewski M, Baker JR Jr. Intravascular and endobronchial DNA delivery to murine lung tissue using a novel, nonviral vector. Hum Gene Ther. 2000;11(10):1385-1395.
24. Bieber T, Meissner W, Kostin S, Niemann A, Elsasser HP. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. J Control Release. 2002;82(2-3):441-454.
25. Huang XG, Xu JQ, Qiu C, et al. Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses. Vaccine. 2007;25(14):2620-2629.
26. Goula D, Becker N, Lemkine GF, et al. Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes. Gene Ther. 2000;7(6):499-504.
27. Garzón MR, Berraondo P, Crettaz J, et al. Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex. Vaccine. 2005;23(11): 1384-1392.
28. Wegmann F, Gartlan KH, Harandi AM, et al. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nat Biotechnol. 2012;9(30):883-888.
29. Yang ZY, Wyatt LS, Kong WP, Moodie Z, Moss B, Nabel GJ. Overcoming immunity to a viral vaccine by DNA priming before vector boosting. J Virol. 2003;77(1):799-803.
30. Feltquate DM, Heaney S, Webster RG, Robinson HL. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol. 1997;158(5):2278-2284.
31. Scheerlinck JP, Casey G, McWaters P, et al. The immune response to a DNA vaccine can be modulated by co-delivery of cytokine genes using a DNA prime-protein boost strategy. Vaccine. 2001;19(28-29): 4053-4060.
32. Kim JJ, Simbiri KA, Sin JI, et al. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV. J Interferon Cytokine Res. 1999;19(1):77-84.
33. Tritel M, Stoddard AM, Flynn BJ, et al. Prime-boost vaccina-ion with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses. J Immunol. 2003;171(5):2538-2547.
34. Pinto AR, Fitzgerald JC, Gao GP, Wilson JM, Ertl HC. Induction of CD8+ T cells to an HIV-1 antigen upon oral immunization of mice with a simian E1-deleted adenoviral vector. Vaccine. 2004;22(5-6): 697-703.
35. Jackson SS, Schmitz JE, Kuroda MJ, et al. Evaluation of CD62L expression as a marker for vaccine-elicited memory cytotoxic T lymphocytes. Immunology. 2005;116(4):443-453.
36. Keating SM, Bejon P, Berthoud T, et al. Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria. J Immunol. 2005;175(9):5675-5680.
37. Roberts AD, Woodland DL. Cutting edge: effector memory CD8+T cells play a prominent role in recall responses to secondary viral infection in the lung. J Immunol. 2004;172(11):6533-6537.
38. Wille-Reece U, Flynn BJ, Loré K, et al. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med. 2006;203(5):1249-1258.
39. Masopust D, Ha SJ, Vezys V, Ahmed R. Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination. J Immunol. 2006;177(2):831-839