메뉴 건너뛰기




Volumn 121, Issue 10, 2008, Pages 939-945

HIV-1/AIDS vaccine development: Are we in the darkness before the dawn?

Author keywords

Human immunodeficiency virus; Neutralization antibody; T cell immunity; Vaccine

Indexed keywords

ADENOVIRUS VECTOR; CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; DOUBLE STRANDED DNA; GAG PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INFLUENZA VACCINE; LIVE VACCINE; NEF PROTEIN; NEUTRALIZING ANTIBODY; ORAL POLIOMYELITIS VACCINE; POL PROTEIN; POLIOMYELITIS VACCINE; PROTEINASE; REV PROTEIN; SINGLE STRANDED RNA; TRANSACTIVATOR PROTEIN; VIRUS ENVELOPE PROTEIN; VPU PROTEIN;

EID: 51149112018     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200805020-00014     Document Type: Article
Times cited : (7)

References (62)
  • 1
    • 36849078038 scopus 로고    scopus 로고
    • Reverse transcription of the HIV-1 pandemic
    • Basavapathruni A, Anderson KS. Reverse transcription of the HIV-1 pandemic. Faseb J 2007; 21: 3795-3808.
    • (2007) Faseb J , vol.21 , pp. 3795-3808
    • Basavapathruni, A.1    Anderson, K.S.2
  • 2
    • 0030902816 scopus 로고    scopus 로고
    • Thomas M, Brady L. HIV integrase: a target for AIDS therapeutics. Trends Biotechnol 1997; 15: 167-172.
    • Thomas M, Brady L. HIV integrase: a target for AIDS therapeutics. Trends Biotechnol 1997; 15: 167-172.
  • 3
    • 33745890578 scopus 로고    scopus 로고
    • The role of neutralizing antibodies in HIV infection
    • Humbert M, Dietrich U. The role of neutralizing antibodies in HIV infection. AIDS Rev 2006; 8: 51-59.
    • (2006) AIDS Rev , vol.8 , pp. 51-59
    • Humbert, M.1    Dietrich, U.2
  • 4
    • 0022967777 scopus 로고
    • CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication
    • Walker CM, Moody DJ, Stites DP, Levy JA. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986; 234: 1563-1566.
    • (1986) Science , vol.234 , pp. 1563-1566
    • Walker, C.M.1    Moody, D.J.2    Stites, D.P.3    Levy, J.A.4
  • 6
    • 0037303113 scopus 로고    scopus 로고
    • Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    • Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, et al. Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol 2003; 77: 2165-2173.
    • (2003) J Virol , vol.77 , pp. 2165-2173
    • Schmitz, J.E.1    Kuroda, M.J.2    Santra, S.3    Simon, M.A.4    Lifton, M.A.5    Lin, W.6
  • 7
    • 0025133520 scopus 로고
    • Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain
    • Scott CF, Jr., Silver S, Profy AT, Putney SD, Langlois A, Weinhold K, Robinson JE. Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain. Proc Natl Acad Sci U S A 1990; 87: 8597-8601.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 8597-8601
    • Scott Jr., C.F.1    Silver, S.2    Profy, A.T.3    Putney, S.D.4    Langlois, A.5    Weinhold, K.6    Robinson, J.E.7
  • 8
    • 0025721018 scopus 로고
    • A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120
    • Ohno T, Terada M, Yoneda Y, Shea KW, Chambers RF, Stroka DM, et al. A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120. Proc Natl Acad Sci U S A 1991; 88: 10726-10729.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10726-10729
    • Ohno, T.1    Terada, M.2    Yoneda, Y.3    Shea, K.W.4    Chambers, R.F.5    Stroka, D.M.6
  • 9
    • 0027985431 scopus 로고
    • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
    • Burton DR, Pyati J, Koduri R, Sharp SJ, Thomton GB, Parren PW, et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 1994; 266: 1024-1027.
    • (1994) Science , vol.266 , pp. 1024-1027
    • Burton, D.R.1    Pyati, J.2    Koduri, R.3    Sharp, S.J.4    Thomton, G.B.5    Parren, P.W.6
  • 10
    • 0032947286 scopus 로고    scopus 로고
    • Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    • Mascola JR, Lewis MG, Stiegler G, Harris D, VanCott TC, Hayes D, et al. Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol 1999; 73: 4009-4018.
    • (1999) J Virol , vol.73 , pp. 4009-4018
    • Mascola, J.R.1    Lewis, M.G.2    Stiegler, G.3    Harris, D.4    VanCott, T.C.5    Hayes, D.6
  • 11
    • 0035175383 scopus 로고    scopus 로고
    • Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes
    • Chen X, Scala G, Quinto I, Liu W, Chun TW, Justement JS, et al. Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes. Nat Med 2001; 7: 1225-1231.
    • (2001) Nat Med , vol.7 , pp. 1225-1231
    • Chen, X.1    Scala, G.2    Quinto, I.3    Liu, W.4    Chun, T.W.5    Justement, J.S.6
  • 12
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    • Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995; 270: 1811-1815.
    • (1995) Science , vol.270 , pp. 1811-1815
    • Cocchi, F.1    DeVico, A.L.2    Garzino-Demo, A.3    Arya, S.K.4    Gallo, R.C.5    Lusso, P.6
  • 13
    • 0029955497 scopus 로고    scopus 로고
    • The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    • Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med 1996; 2: 1244-1247.
    • (1996) Nat Med , vol.2 , pp. 1244-1247
    • Cocchi, F.1    DeVico, A.L.2    Garzino-Demo, A.3    Cara, A.4    Gallo, R.C.5    Lusso, P.6
  • 14
    • 0030670330 scopus 로고    scopus 로고
    • In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
    • Scarlatti G, Tresoldi E, Bjorndal A, Fredriksson R, Colognesi C, Deng HK, et al. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med 1997; 3: 1259-1265.
    • (1997) Nat Med , vol.3 , pp. 1259-1265
    • Scarlatti, G.1    Tresoldi, E.2    Bjorndal, A.3    Fredriksson, R.4    Colognesi, C.5    Deng, H.K.6
  • 15
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994; 68: 4650-4655.
    • (1994) J Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6
  • 17
    • 0033559648 scopus 로고    scopus 로고
    • Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
    • Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J, et al. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 1999; 189: 991-998.
    • (1999) J Exp Med , vol.189 , pp. 991-998
    • Jin, X.1    Bauer, D.E.2    Tuttleton, S.E.3    Lewin, S.4    Gettie, A.5    Blanchard, J.6
  • 18
    • 0034699512 scopus 로고    scopus 로고
    • Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
    • Allen TM, O'Connor DH, Jing P, Dzuris JL, Mothe BR, Vogel TU, et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature 2000; 407: 386-390.
    • (2000) Nature , vol.407 , pp. 386-390
    • Allen, T.M.1    O'Connor, D.H.2    Jing, P.3    Dzuris, J.L.4    Mothe, B.R.5    Vogel, T.U.6
  • 19
    • 16944366524 scopus 로고    scopus 로고
    • Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
    • Goulder PJ, Phillips RE, Colbert RA, McAdam S, Ogg G, Nowak MA, et al. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat Med 1997; 3: 212-217.
    • (1997) Nat Med , vol.3 , pp. 212-217
    • Goulder, P.J.1    Phillips, R.E.2    Colbert, R.A.3    McAdam, S.4    Ogg, G.5    Nowak, M.A.6
  • 20
    • 0035808775 scopus 로고    scopus 로고
    • Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
    • Kelleher AD, Long C, Holmes EC, Allen RL, Wilson J, Conlon C, et al. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J Exp Med 2001; 193: 375-386.
    • (2001) J Exp Med , vol.193 , pp. 375-386
    • Kelleher, A.D.1    Long, C.2    Holmes, E.C.3    Allen, R.L.4    Wilson, J.5    Conlon, C.6
  • 21
    • 33744990609 scopus 로고    scopus 로고
    • Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys
    • Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, et al. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 2006; 312: 1530-1533.
    • (2006) Science , vol.312 , pp. 1530-1533
    • Letvin, N.L.1    Mascola, J.R.2    Sun, Y.3    Gorgone, D.A.4    Buzby, A.P.5    Xu, L.6
  • 22
    • 0023187204 scopus 로고
    • Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees
    • Hu SL, Fultz PN, McClure HM, Eichberg JW, Thomas EK, Zarling J, et al. Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees. Nature 1987; 328: 721-723.
    • (1987) Nature , vol.328 , pp. 721-723
    • Hu, S.L.1    Fultz, P.N.2    McClure, H.M.3    Eichberg, J.W.4    Thomas, E.K.5    Zarling, J.6
  • 23
    • 0023114641 scopus 로고
    • Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease
    • Redfield RR, Wright DC, James WD, Jones TS, Brown C, Burke DS. Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease. N Engl J Med 1987; 316: 673-676.
    • (1987) N Engl J Med , vol.316 , pp. 673-676
    • Redfield, R.R.1    Wright, D.C.2    James, W.D.3    Jones, T.S.4    Brown, C.5    Burke, D.S.6
  • 24
    • 0042335760 scopus 로고    scopus 로고
    • Smallpox vaccine: Contraindications, administration, and adverse reactions
    • Maurer DM, Harrington B, Lane JM. Smallpox vaccine: contraindications, administration, and adverse reactions. Am Fam Physician 2003; 68: 889-896.
    • (2003) Am Fam Physician , vol.68 , pp. 889-896
    • Maurer, D.M.1    Harrington, B.2    Lane, J.M.3
  • 26
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 1992; 258: 1938-1941.
    • (1992) Science , vol.258 , pp. 1938-1941
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3    Sehgal, P.K.4    Desrosiers, R.C.5
  • 27
    • 0028944667 scopus 로고
    • Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
    • Baba TW, Jeong YS, Pennick D, Bronson R, Greene MF, Ruprecht RM. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 1995; 267: 1820-1825.
    • (1995) Science , vol.267 , pp. 1820-1825
    • Baba, T.W.1    Jeong, Y.S.2    Pennick, D.3    Bronson, R.4    Greene, M.F.5    Ruprecht, R.M.6
  • 28
    • 0032905068 scopus 로고    scopus 로고
    • Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
    • Baba TW, Liska V, Khimani AH, Ray NB, Dailey PJ, Penninck D, et al. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med 1999; 5: 194-203.
    • (1999) Nat Med , vol.5 , pp. 194-203
    • Baba, T.W.1    Liska, V.2    Khimani, A.H.3    Ray, N.B.4    Dailey, P.J.5    Penninck, D.6
  • 30
    • 0031764239 scopus 로고    scopus 로고
    • Development of bivalent rgp120 vaccines to prevent HIV type 1 infection
    • Berman PW. Development of bivalent rgp120 vaccines to prevent HIV type 1 infection. AIDS Res Hum Retroviruses 1998; 14 Suppl3: s277-s289.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , Issue.SUPPL.3
    • Berman, P.W.1
  • 31
    • 0037470407 scopus 로고    scopus 로고
    • Public health. AIDS vaccine trial produces disappointment and confusion
    • Cohen J. Public health. AIDS vaccine trial produces disappointment and confusion. Science 2003; 299: 1290-1291.
    • (2003) Science , vol.299 , pp. 1290-1291
    • Cohen, J.1
  • 32
    • 7244229666 scopus 로고    scopus 로고
    • Recruitment and baseline epidemiologic profile of participants in the first phase 3 HIV vaccine efficacy trial
    • Harro CD, Judson FN, Gorse GJ, Mayer KH, Kostman JR, Brown SJ, et al. Recruitment and baseline epidemiologic profile of participants in the first phase 3 HIV vaccine efficacy trial. J Acquir Immune Defic Syndr 2004; 37: 1385-1392.
    • (2004) J Acquir Immune Defic Syndr , vol.37 , pp. 1385-1392
    • Harro, C.D.1    Judson, F.N.2    Gorse, G.J.3    Mayer, K.H.4    Kostman, J.R.5    Brown, S.J.6
  • 33
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-1749.
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3    Rhodes, G.H.4    Felgner, P.L.5    Dwarki, V.J.6
  • 34
    • 0033761221 scopus 로고    scopus 로고
    • Preventing AIDS but not HIV-1 infection with a DNA vaccine
    • She X, Siliciano RF. Preventing AIDS but not HIV-1 infection with a DNA vaccine. Science 2000; 290: 463-465.
    • (2000) Science , vol.290 , pp. 463-465
    • She, X.1    Siliciano, R.F.2
  • 35
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000; 290:486-492.
    • (2000) Science , vol.290 , pp. 486-492
    • Barouch, D.H.1    Santra, S.2    Schmitz, J.E.3    Kuroda, M.J.4    Fu, T.M.5    Wagner, W.6
  • 36
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: Immunology application, and optimization
    • Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology application, and optimization. Annu Rev Immunol 2000; 18: 927-974.
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 37
    • 33947146120 scopus 로고    scopus 로고
    • Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses
    • Huang X, Xu J, Qiu C, Ren L, Liu L, Wan Y, et al. Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses. Vaccine 2007; 25: 2620-2629.
    • (2007) Vaccine , vol.25 , pp. 2620-2629
    • Huang, X.1    Xu, J.2    Qiu, C.3    Ren, L.4    Liu, L.5    Wan, Y.6
  • 38
    • 0035815437 scopus 로고    scopus 로고
    • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    • Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 2001; 292: 69-74.
    • (2001) Science , vol.292 , pp. 69-74
    • Amara, R.R.1    Villinger, F.2    Altman, J.D.3    Lydy, S.L.4    O'Neil, S.P.5    Staprans, S.I.6
  • 39
    • 0037083309 scopus 로고    scopus 로고
    • Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys
    • Santra S, Schmitz JE, Kuroda MJ, Lifton MA, Nickerson CE, Lord CI, et al. Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys. J Immunol 2002; 168: 1847-1853.
    • (2002) J Immunol , vol.168 , pp. 1847-1853
    • Santra, S.1    Schmitz, J.E.2    Kuroda, M.J.3    Lifton, M.A.4    Nickerson, C.E.5    Lord, C.I.6
  • 40
    • 20944447526 scopus 로고    scopus 로고
    • Comparison of whole gene and whole virus scrambled antigen approaches for DNA prime and fowlpox virus boost HIV type 1 vaccine regimens in macaques
    • Pamungkas J, De Rose R, Iskandriati D, Noviana R, Paramastri Y, Dale CJ, et al. Comparison of whole gene and whole virus scrambled antigen approaches for DNA prime and fowlpox virus boost HIV type 1 vaccine regimens in macaques. AIDS Res Hum Retroviruses 2005; 21; 292-300.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 292-300
    • Pamungkas, J.1    De Rose, R.2    Iskandriati, D.3    Noviana, R.4    Paramastri, Y.5    Dale, C.J.6
  • 42
    • 38749132973 scopus 로고    scopus 로고
    • An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
    • Harari A, Bart PA, Stohr W, Tapia G, Garcia M, Medjitna-Rais E, et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med 2008; 205: 63-77.
    • (2008) J Exp Med , vol.205 , pp. 63-77
    • Harari, A.1    Bart, P.A.2    Stohr, W.3    Tapia, G.4    Garcia, M.5    Medjitna-Rais, E.6
  • 43
    • 1542299092 scopus 로고    scopus 로고
    • Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors
    • Shiver JW, Emini EA. Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors. Annu Rev Med 2004; 55: 355-372.
    • (2004) Annu Rev Med , vol.55 , pp. 355-372
    • Shiver, J.W.1    Emini, E.A.2
  • 44
    • 36249005448 scopus 로고    scopus 로고
    • AIDS research. Did Merck's failed HIV vaccine cause harm?
    • Cohen J. AIDS research. Did Merck's failed HIV vaccine cause harm? Science 2007; 318: 1048-1049.
    • (2007) Science , vol.318 , pp. 1048-1049
    • Cohen, J.1
  • 45
    • 36248941489 scopus 로고    scopus 로고
    • HIV vaccine may raise risk
    • Ledford H. HIV vaccine may raise risk. Nature 2007; 450: 325.
    • (2007) Nature , vol.450 , pp. 325
    • Ledford, H.1
  • 46
    • 35148818748 scopus 로고    scopus 로고
    • AIDS research. Promising AIDS vaccine's failure leaves field reeling
    • Cohen J. AIDS research. Promising AIDS vaccine's failure leaves field reeling. Science 2007; 318: 28-29.
    • (2007) Science , vol.318 , pp. 28-29
    • Cohen, J.1
  • 48
    • 0034176364 scopus 로고    scopus 로고
    • The prime-boost strategy: Exciting prospects for improved vaccination
    • Ramshaw LA, Ramsay AJ. The prime-boost strategy: exciting prospects for improved vaccination. Immunol Today 2000; 21: 163-165.
    • (2000) Immunol Today , vol.21 , pp. 163-165
    • Ramshaw, L.A.1    Ramsay, A.J.2
  • 49
    • 0037189323 scopus 로고    scopus 로고
    • Diversity considerations in HIV-1 vaccine selection
    • Gaschen B, Taylor J, Yusim K, Foley P, Gao F, Lang D, et al. Diversity considerations in HIV-1 vaccine selection. Science 2002; 296: 2354-2360.
    • (2002) Science , vol.296 , pp. 2354-2360
    • Gaschen, B.1    Taylor, J.2    Yusim, K.3    Foley, P.4    Gao, F.5    Lang, D.6
  • 50
    • 0036094391 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 subtype C molecular phylogeny: Consensus sequence for an AIDS vaccine design?
    • Novitsky V, Smith UR, Gilbert P, McLane MF, Chigwedere P, Williamson C, et al. Human immunodeficiency virus type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design? J Virol 2002; 76: 5435-5451.
    • (2002) J Virol , vol.76 , pp. 5435-5451
    • Novitsky, V.1    Smith, U.R.2    Gilbert, P.3    McLane, M.F.4    Chigwedere, P.5    Williamson, C.6
  • 52
    • 33846301454 scopus 로고    scopus 로고
    • Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine
    • Yan J, Yoon H, Kumar S, Ramanathan MP, Corbitt N, Kutzler M, et al. Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine. Mol Ther 2007; 15: 411-421.
    • (2007) Mol Ther , vol.15 , pp. 411-421
    • Yan, J.1    Yoon, H.2    Kumar, S.3    Ramanathan, M.P.4    Corbitt, N.5    Kutzler, M.6
  • 53
    • 34547811379 scopus 로고    scopus 로고
    • Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteins
    • Rolland M, Jensen MA, Nickle DC, Yan J, Learn GH, Heath L, et al. Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteins. J Virol 2007; 81: 8507-8514.
    • (2007) J Virol , vol.81 , pp. 8507-8514
    • Rolland, M.1    Jensen, M.A.2    Nickle, D.C.3    Yan, J.4    Learn, G.H.5    Heath, L.6
  • 54
    • 0242576821 scopus 로고    scopus 로고
    • Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines
    • Kong WP, Huang Y, Yang ZY, Chakrabarti BK, Moodie Z, Nabel GJ. Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines. J Virol 2003; 77: 12764-12772.
    • (2003) J Virol , vol.77 , pp. 12764-12772
    • Kong, W.P.1    Huang, Y.2    Yang, Z.Y.3    Chakrabarti, B.K.4    Moodie, Z.5    Nabel, G.J.6
  • 55
    • 20244366399 scopus 로고    scopus 로고
    • Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate
    • Chakrabarti BK, Ling X, Yang ZY, Montefiori DC, Panet A, Kong WP, et al. Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate. Vaccine 2005; 23: 3434-3445.
    • (2005) Vaccine , vol.23 , pp. 3434-3445
    • Chakrabarti, B.K.1    Ling, X.2    Yang, Z.Y.3    Montefiori, D.C.4    Panet, A.5    Kong, W.P.6
  • 56
    • 13944277994 scopus 로고    scopus 로고
    • Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys
    • Seaman MS, Xu L, Beaudry K, Martin KL, Beddall MH, Miura A, et al. Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys. J Virol 2005; 79: 2956-2963.
    • (2005) J Virol , vol.79 , pp. 2956-2963
    • Seaman, M.S.1    Xu, L.2    Beaudry, K.3    Martin, K.L.4    Beddall, M.H.5    Miura, A.6
  • 57
    • 20744452323 scopus 로고    scopus 로고
    • Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human immunodeficiency virus Env and Gag immunogens
    • Wu L, Kong WP, Nabel GJ. Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human immunodeficiency virus Env and Gag immunogens. J Virol 2005; 79: 8024-8031.
    • (2005) J Virol , vol.79 , pp. 8024-8031
    • Wu, L.1    Kong, W.P.2    Nabel, G.J.3
  • 58
    • 33751226889 scopus 로고    scopus 로고
    • Sequential priming and boosting with hetorologous HIV immunogens predominantly stimulated T cell immunity against conserved epitopes
    • Xu J, Ren L, Huang X, Qiu C, Liu Y, Liu Y, et al. Sequential priming and boosting with hetorologous HIV immunogens predominantly stimulated T cell immunity against conserved epitopes. AIDS 2006; 20: 2293-2303.
    • (2006) AIDS , vol.20 , pp. 2293-2303
    • Xu, J.1    Ren, L.2    Huang, X.3    Qiu, C.4    Liu, Y.5    Liu, Y.6
  • 59
    • 33751071573 scopus 로고    scopus 로고
    • Combination DNA plus protein HIV vaccines
    • Lu S. Combination DNA plus protein HIV vaccines. Springer Semin Immunopathol 2006; 28: 255-265.
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 255-265
    • Lu, S.1
  • 61
    • 38949214786 scopus 로고    scopus 로고
    • CD4-induced epitopes in the HIV envelope glycoprotein, gp120
    • DeVico AL. CD4-induced epitopes in the HIV envelope glycoprotein, gp120. Curr HIV Res 2007; 5: 561-571.
    • (2007) Curr HIV Res , vol.5 , pp. 561-571
    • DeVico, A.L.1
  • 62
    • 34547154404 scopus 로고    scopus 로고
    • Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization
    • Zhang PF, Chain F, Dong M, Choudhary A, Bouma P, Zhang Z, et al. Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization. Proc Natl Acad Sci U S A 2007; 104: 10193-10198.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10193-10198
    • Zhang, P.F.1    Chain, F.2    Dong, M.3    Choudhary, A.4    Bouma, P.5    Zhang, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.