Addiction is not a brain disease (and it matters)

Frontiers in Psychiatry

Volumn 4, Issue APR, 2013, Pages

  Levy, Neil ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Addiction; Agency; Disease; Dysfunction; Well being

Indexed keywords

DOPAMINE; OPIATE;

ADDICTION; ARTICLE; BRAIN DISEASE; BRAIN FUNCTION; COGNITIVE DEFECT; DECISION MAKING; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC SYSTEM; DRUG ABUSE; ENVIRONMENTAL FACTOR; HUMAN; LEARNING DISORDER; LIMBIC SYSTEM; MESENCEPHALON; NERVE TRACT; NEUROPHYSIOLOGY; PATHOPHYSIOLOGY; REINFORCEMENT; REWARD; SELF CONTROL; SOCIAL STATUS; WITHDRAWAL SYNDROME;

EID: 84877702702     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2013.00024     Document Type: Article

References (30)

1. Baumeister, R. F., and Vohs, K. D. (2007). Self-regulation, ego depletion, and motivation. Soc. Personal. Psychol. Compass 1, 1-14.
2. Berridge, K. C. (2007). The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl.) 191, 391-431.
3. Booth, M. (1996). Opium: A history. London: Simon and Schuster.
4. Buchanan, A., Brock, D. W., Daniels, N., and Wikler, D. (2000). From Chance to Choice: Genetics and Justice. Cambridge: Cambridge University Press.
5. Carter, A., and Hall, W. (2012). Addiction Neuroethics: The Promises and Perils of Neuroscience Research on Addiction. Cambridge: Cambridge University Press.
6. Cosmides, L., and Tooby, J. (1992). "Cognitive adaptations for social exchange," in The Adapted Mind, eds J. Barkow, L. Cosmides, and J. Tooby (NewYork: Oxford University Press), 163-228.
7. Cummins, R. (1975). Functional analysis. J. Philos. 72, 741.765.
8. Durrant, R., Adamson, S., Todd, F., and Sellman, D. (2009). Drug use and addiction: an evolutionary perspective. Aust. N. Z. J. Psychiatry 43, 1049-1056.
9. Goldstein, R. Z., and Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am. J. Psychiatry 159, 1642-1652.
10. Graham, G. (2010). The Disordered Mind. NewYork: Routledge.
11. Koob, G. F., and Le Moal, M. (1997). Drug abuse: hedonic homeostatic dysregulation. Science 278, 52-58.
12. Koob, G. F., and Le Moal, M. (2008). Addiction and the brain antireward system. Annu. Rev. Psychol. 59, 29-53.
13. Leshner, A. I. (1997). Addiction is a brain disease, and it matters. Science 278, 45-44.
14. Levy, N. (2007). The social: a missing term in the debate over addiction and voluntary control. AJOB Neurosci. 7, 35-36.
15. Millikan, R. G. (1984). Language, Thought and Other Biological Categories. Cambridge, MA: MIT Press.
16. Montague, P. R., Dayan, P., and Sejnowski, T. J. (1996). A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16, 1936-1947.
17. Murphy, D. (2006). Psychiatry in the Scientific Image. Cambridge, MA: MIT Press.
18. Murphy, D., and Stich, S. (2000). "Darwin in the madhouse: evolutionary psychology and the classification of mental disorders," in Evolution and the Human Mind: Modularity, Language and Meta-Cognition, eds P. Carruthers and A. Chamberlain (Cambridge: Cambridge University Press), 62-92.
19. Nesse,R. M.,and Williams,G. C. (1995). Why We Get Sick. New York: Times Books.
20. Pickard, H. (2012). The purpose in chronic addiction. AJOB Neurosci. 3, 40-49.
21. Roe, K., and Murphy, D. (2011). "Function, dysfunction, and adaptation?" in Maladapting Minds: Philosophy, Psychiatry, and Evolutionary Theory, ed. P. R. Adriaens and A. de Block (Oxford: Oxford University Press), 216-237.
22. Ross, D., Sharp, C., Vuchinich, R. E., and Spurrett, D. (2008). Midbrain Mutiny: The Picoeconomics and Neuroeconomics of Disordered Gambling. Cambridge: MIT Press.
23. Schultz, W., Apicella, P., Scarnati, E., and Ljungberg, T. (1992). Neuronal activity in monkey ventral striatum related to the expectation of reward. J. Neurosci. 12, 4595-4610.
24. Schultz, W., Dayan, P., and Montague, P. R. (1997). A neural substrate of prediction and reward. Science 275, 1593-1159.
25. Solinas, M., Ferré, S., You, Z.-B., Karcz-Kubicha, M., Popoli, P., and Goldberg, S. R. (2002). Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. J. Neurosci. 22, 6321-6324.
26. Sullivan, R. J., and Hagen, E. H. (2002). Psychotropic substanceseeking: evolutionary pathology or adaptation? Addiction 97, 389-340.
27. Sutton, R. S., and Barto, A. C. (1998). Reinforcement learning: An introduction. London: MIT Press.
28. Volkow, N. D., and Li, T. K. (2004). Drug addiction: the neurobiology of behaviour gone awry. Nat. Rev. Neurosci. 5, 963-970.
29. Wakefield, J. C. (1992). The concept of mental disorder: on the boundary between biological facts and social values. Am. Psychol. 47, 373-388.
30. Wilson, E. O. (1975). Sociobiology: The New Synthesis. Cambridge, MA: Harvard University Press.