Role of amphiphilicity in the design of synthetic mimics of antimicrobial peptides with gram-negative activity

ACS Medicinal Chemistry Letters

Volumn 4, Issue 5, 2013, Pages 481-485

  Thaker, Hitesh D ^a   Cankaya, Alper ^a   Scott, Richard W ^b   Tew, Gregory N ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b PolyMedix Inc   (United States)

Author keywords

amphiphilicity; antimicrobial peptides (AMPs); disrupted amphiphilic; facially amphiphilic; Gram negative; Gram positive; hydrophobicity; integy moment (IW); Suzuki coupling; synthetic mimics of antimicrobial peptides (SMAMPs); Volsurf software

Indexed keywords

AMIDE; POLYPEPTIDE ANTIBIOTIC AGENT; SYNTHETIC MIMIC OF ANTIMICROBIAL PEPTIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL BOND; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 84877702474     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300307b     Document Type: Article

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