Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators

ACS Medicinal Chemistry Letters

Volumn 4, Issue 5, 2013, Pages 475-480

  Yu, Li Fang ^a   Li, Yuan Yuan ^a   Su, Ming Bo ^a   Zhang, Mei ^a   Zhang, Wei ^a   Zhang, Li Na ^a   Pang, Tao ^a   Zhang, Run Tao ^a   Liu, Bing ^a   Li, Jing Ya ^a   Li, Jia ^a   Nan, Fa Jun ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

alkene oxindole; AMPK activator; diabetes; DIO mouse model; insulin sensitivity

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ALKENE OXINDOLE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INSULIN; METFORMIN; OXINDOLE; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; LIPID METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 84877695456     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400028q     Document Type: Article

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