Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry

Biomedical Chromatography

Volumn 24, Issue 5, 2010, Pages 479-489

  Hu, Yong Mei ^a   Wang, Yi Tao ^b   Sze, Stephen C W ^a   Tsang, K W ^a   Wong, H K ^a   Liu, Qing ^a   Zhong, Li Dan ^a   Tong, Yao ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b University of Macau   (Macao)

Author keywords

Erxian Decoction (EXD); LC DAD ESI MS; Menopausal syndromes; Metabolites; Pharmacokinetic study; Traditional Chinese medicine prescriptions (TCMP)

Indexed keywords

BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINE; METABOLITES; ULTRAVIOLET SPECTROSCOPY;

CHEMICAL CONSTITUENTS; CHINESE MEDICINE PRESCRIPTIONS; ERXIAN DECOCTION; LC-DAD-ESI-MS; MENOPAUSAL SYNDROME; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; RAT PLASMA; TRADITIONAL CHINESE MEDICINE; TRADITIONAL CHINESE MEDICINE PRESCRIPTION;

RATS;

3 O FERUOYLQUINIC ACID; ALKALOID; BAOHUOSIDE I; BERBERINE; CHINESE DRUG; CURCULIGOSIDE; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; ERXIAN DECOCTION FRACTION; FERULIC ACID; ICARIIN; ICARISIDE; ISOQUINOLINE ALKALOID; JATRORRHIZINE; LOTUSINE; MAGNOFLORINE; MANGIFERIN; MENISPERINE; NEOMANGIFERIN; OBLONGINE; PALMATINE; PHELLODENDRINE; PHENOL; SAGITTATOSIDE A; SAPONIN; TIMOSAPONIN D; TIMOSAPONIN N; UNCLASSIFIED DRUG; UNINDEXED DRUG; XILINGSAPONIN B;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG ABSORPTION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG RETENTION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; IN VIVO STUDY; INTESTINE; KIDNEY; LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; LIVER; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLITE; NONHUMAN; OVARY; PLASMA; RAT; ULTRAVIOLET SPECTROSCOPY;

RATTUS;

EID: 77951763374     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1315     Document Type: Article

References (18)

1. Chen XJ, Guo BL, Li SP, Zhang QW, Tu PF and Wang YT. Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 2007; 1163: 96-104. (Pubitemid 47247697)
2. Chen XJ, Ji H, Zhang QW, Tu PF, Wang YT, Guo BL and Li SP. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 2008; 46: 226-235. (Pubitemid 351516294)
3. Ge BY, Chen HX, Han FM and Chen Y. Identification of amygdalin and its major metabolites in rat urine by LC-MS/MS. Journal of Chromatography B 2007; 857: 281-286. (Pubitemid 47449671)
4. Hong YF, Zhang GM, Sun LN, Han GY and Ji GZ. Isolation and identification of steroidal saponins from Anemarrhena asphodeloides Bunge. Acta Pharmaceutica Sinica 1999; 34: 518-521.
5. Hua WY, Ding L, Chen Y, Dong B, He JC and Xu GL. Determination of berberine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2007; 44: 931-937. (Pubitemid 47095187)
6. Kang LP, Ma BP, Shi TJ, Zhang J and Xiong CQ. Two new furostanol saponins from the rhizomes of Anemarrhena asphodeloides. Acta Pharmaceutica Sinica 2006; 41: 527-532. (Pubitemid 44174280)
7. Kite GC, Porter EA and Simmonds MS-J. Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry. Journal of Chromatography A 2007; 1148: 177-183.
8. Li YF, Gong ZH, Yang M, Zhao YM and Luo ZP. Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells. Life Science 2003; 72: 933-942. (Pubitemid 36001984)
9. Liu Q, Shi JR, Yang Y, Fang ZQ, Liang SH and Guo RX. Eff ects on secretory function of rat gonad by erxian decoction and its disassemblied pprescriptions. China Journal of Chinese Materia Medica 2005; 30: 1023-1026. (Pubitemid 44724741)
10. Lu T, Liang Y, Song J, Xie L, Wang GJ and Liu XD. Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method. Journal of Pharmaceutical and Biomedical Analysis 2006; 40: 1218-1224. (Pubitemid 43247461)
11. Ma BP, Dong JX, Wang BJ and Yan XZ. Studies on the furostanol saponins from Anemarrhena asphodeloides Bunge. Acta Pharmaceutica Sinica 1996; 31: 271-277.
12. Ma CH, Fan MS, Tang YH, Li ZX, Sun ZL, Ye G and Huang CG. Identification of major alkoloids and steroidal saponins in rat serum by HPLC-diode array detection-MS/MS following oral administration of Huangbai-Zhimu herb-pair extract. Biomedical Chromatography 2008; 22: 835-850.
13. Nian H, Qin LP, Zhang QY, Zheng HC, Yu Y and Huang BK. Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats. Journal of Ethnopharmacology 2006; 108: 96-102. (Pubitemid 44498986)
14. Sze SCW, Tong Y, Zhang YB, Zhang ZJ, Lan ASL, Wang HK, Tsang KW and Ng TB. A novel mechanism: Erxian Decoction. A Chinese medicine formula, for relieving menopausal syndrome. Journal of Ethnopharmacology 2009; 123: 27-33.
15. Wang DG, Hang TJ, Wu CY and Liu WY. Identification of the major metabolites of resceratrol in rat urine by HPLC-MS/MS. Journal of Chromatography B 2005; 829(1-2): 97-106.
16. Wang ZQ and Lou YJ. Proliferation-simulating eff ects of icaritin and desmethylicaritin in MCF-7 cells. European journal of Pharmacology 2004; 504(3): 147-153.
17. Zhang YF, Shi QR, Shi PY, Zhang WD and Cheng YY. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin-Guo-Lan (Tinospora sagittata and Tinospora capillipes) by highperformance liquid chromatography/electrospray onization with multistage mass spectrometry. Rapid Communications in Mass Spectrometry 2006; 20: 2328-2342.
18. Zhao HY, Sun JH, Fan MX, Li F, Zhou L, Li Z, Han J, Wang BR and Guo DA. Analysis of phenolic compounds in Epimedium plants using liquid chromatography coupled with electrospray ionization mass spectrometry Journal of Chromatography A 2008; 1190(1-2): 157-181.