Kinetic analysis of inhibition of glucoamylase and active site mutants via chemoselective oxime immobilization of acarbose on SPR chip surfaces

Carbohydrate Research

Volumn 375, Issue , 2013, Pages 21-28

  Sauer, Jørgen ^a,c   Abou Hachem, Maher ^b   Svensson, Birte ^b   Jensen, Knud J ^a   Thygesen, Mikkel B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Aldose oximes; Enzyme inhibitors; Molecular recognition; Self assembly; Surface plasmon resonance

Indexed keywords

ALDOSE OXIMES; CONFORMATIONAL CHANGE; DISSOCIATION RATE CONSTANT; ENZYME INHIBITORS; ENZYME-INHIBITOR COMPLEX; FUNCTIONALIZATIONS; IMMOBILIZED ENZYME; QUANTITATIVE STUDY;

AMINO ACIDS; ASSOCIATION REACTIONS; DISSOCIATION; KINETICS; MOLECULAR RECOGNITION; PLASMONS; RATE CONSTANTS; SELF ASSEMBLY; SURFACE PLASMON RESONANCE;

ENZYME INHIBITION;

ACARBOSE; GLUCAN 1,4 ALPHA GLUCOSIDASE; MUTANT PROTEIN; OXIME; TETRASACCHARIDE;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME IMMOBILIZATION; ENZYME INHIBITION; ENZYME KINETICS; MOLECULAR DOCKING; MOLECULAR INTERACTION; PH; PRIORITY JOURNAL; SENSOR; SURFACE PLASMON RESONANCE;

ACARBOSE; CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCAN 1,4-ALPHA-GLUCOSIDASE; GOLD; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; SURFACE PROPERTIES;

EID: 84877667169     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2013.04.012     Document Type: Article

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