Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Food Chemistry

Volumn 141, Issue 1, 2013, Pages 148-152

  Habib, Hosam M ^a   Ibrahim, Wissam H ^a   Schneider Stock, Regine ^b   Hassan, Hassan M ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Camel milk; DNA damage; DPPH; FRAP; HCT 116 colon cancer cells; Lactoferrin

Indexed keywords

AGENTS; ANTIOXIDANTS; ASSAYS; CELL CULTURE; CELLS; DNA; FREE RADICALS; NITRIC OXIDE;

CAMEL MILKS; COLON CANCER CELLS; DNA DAMAGES; DPPH; FRAP; LACTOFERRIN;

DISEASES;

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ASCORBIC ACID; DNA; LACTOFERRIN; NITRIC OXIDE; RUTOSIDE;

ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CAMEL; CANCER CELL; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; IN VITRO STUDY; MILK; SCAVENGING SYSTEM;

EID: 84877631392     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.03.039     Document Type: Article

References (16)

1. Adlerova, L., Bartoskova, A., & Faldyna, M. (2008). Lactoferrin: A review. Veterinarni Medicina, 9, 457-468.
2. Benzie, I. F. F., & Strain, J. J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Analytical Biochemistry, 239, 70-76.
3. Bezault, J., Bhimani, R., Wiprovnick, J., & Furmanski, P. (1994). Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Research, 54, 2310-2312. (Pubitemid 24138715)
4. De Ancos, B., Sgroppo, S., Plaza, L., & Cano, M. P. (2002). Possible nutritional and health-related value promotion in orange juice preserved by high-pressure treatment. Journal of the Science of Food and Agriculture, 82, 790-796. (Pubitemid 34589466)
5. Fujita, K., Matsuda, E., Sekine, K., Iigo, M., & Tsuda, H. (2004). Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis, 25, 1961-1966. (Pubitemid 39405916)
6. Guitteridge, J. M. (1984). Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate. Biochemical Journal, 224, 761-767.
7. Young, J., Je Park, P.-J., Kim, E.-K., & Ahn, C.-B. (2009). Antioxidant and angiotensin I converting enzyme inhibitory activity. Food Chemistry, 113, 932-935.
8. Kumar, A., & Chattopadhyay, S. (2007). DNA damage protecting activity and antioxidant potential of pudina extract. Food Chemistry, 100, 1377-1384. (Pubitemid 44160746)
9. Metz-Boutique, M. H., Jolles, J., Mazurier, J., Schoentgen, F., Legrand, D., Spik, G., et al.. (1984). Human lactotransferrin: Amino acid sequence and structural comparisons with other transferrins. European Journal of Biochemistry, 145, 659-676. (Pubitemid 15178137)
10. Mickuviene, I., Kirveliene, V., & Juodka, B. (2004). Experimental survey of nonclonogenic viability assays for adherent cells in vitro. Toxicology In Vitro, 18, 639-648. (Pubitemid 38900872)
11. Prieto, P., Pineda, M., & Aguilar, M. (1999). Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E. Analytical Biochemistry, 269, 337-341. (Pubitemid 29201033)
12. Sreejayan, N., & Rao, M. N. A. (1997). Nitric oxide scavenging by curcuminoids. Journal of Pharmacy and Pharmacology, 49, 105-107. (Pubitemid 27051040)
13. Wang, W. P., Iigo, M., Sato, J., Sekine, K., Adachi, I., & Tsuda, H. (2000). Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Japanese Journal of Cancer Research, 91, 1022-1027.
14. Wolf, J. S., Li, D., Taylor, R. J., & O'malley, B. W. Jr., (2003). Lactoferrin inhibits growth of malignant tumors of the head and neck. ORL; Journal for Oto-Rhino-Laryngology and its Related Specialties, 65, 245-249. (Pubitemid 38134868)
15. Xu, B. J., & Chang, S. K. C. (2007). A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. Journal of Food Science, 72, 159-166.
16. Zemann, N., Klein, P., Wetzel, E., Huettinger, F., & Huettinger, M. (2010). Lactoferrin induces growth arrest and nuclear accumulation of Smad-2 in HeLa cells. Biochimie, 92, 880-884.