Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts

Journal of Cardiovascular Pharmacology

Volumn 61, Issue 5, 2013, Pages 416-422

  Wei, Chao ^a   Li, Hongxia ^a   Han, Lianhua ^a   Zhang, Lei ^a   Yang, Xiangjun ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CATHEPSIN D; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MESSENGER RNA; PROTEIN BAD; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; HEART VENTRICLE; ISCHEMIC POSTCONDITIONING; LYSOSOME; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TRANSMISSION ELECTRON MICROSCOPY;

ADENINE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; DNA PRIMERS; GENE EXPRESSION; HEART; HEMODYNAMICS; ISCHEMIC POSTCONDITIONING; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84877626889     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318287d501     Document Type: Article

References (34)

1. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science. 2000;290:1717-1721.
2. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
3. Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol. 2005;25:1025-1040.
4. Nishino I, Fu J, Tanji K, et al. Primary LAMP-2 deficiency causes Xlinked vacuolar cardiomyopathy and myopathy (Danon disease). Nature. 2000;406:906-910.
5. Zhao ZQ, Vinten-Johansen J. Postconditioning: reduction of reperfusioninduced injury. Cardiovasc Res. 2006;70:200-211.
6. Tawa M, Fukumoto T, Yamashita N, et al. Postconditioning improves postischemic cardiac dysfunction independently of norepinephrine overflow after reperfusion in rat hearts: comparison with preconditioning. J Cardiovasc Pharmacol. 2010;55:6-13.
7. Balakumar P, Rohilla A, Singh M. Preconditioning and postconditioning to limit ischemia reperfusion-induced myocardial injury: what could be the next footstep? Pharmacol Res. 2008;57:403-412.
8. Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol. 2004;36:2491-2502.
9. Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2004;36:2503-2518.
10. Fortunato F, Kroemer G. Impaired autophagosome-lysosome fusion in the pathogenesis of pancreatitis. Autophagy. 2009;5:850-853.
11. Hasui K, Wang J, Jia XH, et al. Enhanced autophagy and reduced expression of cathepsin D are related to autophagic cell death in Epstein-Barr virus-associated nasal natural killer/T-cell Lymphomas: an immunohistochemical analysis of beclin-1, LC3, mitochondria (AE-1), and cathepsin D in nasopharyngeal lymphomas. Acta Histochem Cytochem. 2011;44: 119-131.
12. Troncoso R, Vicencio JM, Parra V, et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res. 2012;93:320-329.
13. Zhai P, Sciarretta S, Galeotti J, et al. Differential roles of GSK-3b during myocardial ischemia and ischemia/reperfusion. Circ Res. 2011;109:502-511.
14. Georgescu SP, Aronovitz MJ, Iovvanna JL, et al. Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. Am J Physiol Cell Physiol. 2011;301:1046-1056.
15. Frustaci A, Sabbioni E, Fortaner S, et al. Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium/zinc infusion. Eur J Heart Fail. 2012;14:202-210.
16. Mughal W, Kirshenbaum LA. Cell death signaling mechanisms in heart failure. Exp Clin Cardiol. 2011;16:102-108.
17. Yan L, Vatner DE, Kim SJ, et al. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A. 2005;102:13807-13812.
18. Elsasser A, Vogt AM, Nef H, et al. Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death. J Am Coll Cardiol. 2004;43:2191-2199.
19. Knaapen MW, Davies MJ, De BM, et al. Apoptotic versus autophagic cell death in heart failure. Cardiovasc Res. 2001;51:304-312.
20. Mizushima N, Yamamoto A, Matsui M, et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101-1111.
21. Petiot A, Ogier-Denis E, Blommaart EF, et al. Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem. 2000;275:992-998.
22. Aki T, Yamaguchi K, Fujimiya T, et al. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocytederived cell line H9c2. Oncogene. 2003;22:8529-8535.
23. Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits Beclin1- mediated autophagic cell death in cardiac myocytes exposed to ischaemia/ reperfusion injury. J Mol Cell Cardiol. 2006;40:846-852.
24. Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100:914-922.
25. Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432:1032-1036.
26. Liu Y, Schiff M, Talloczy Z, et al. Autophagy genes are essential for limiting the spread of programmed cell death associated with plant innate immunity. Cell. 2005;120:567-577.
27. Lum JJ, Berardinis RJ, Thompson CB. Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol. 2005;6:439-448.
28. Nakai A, Yamaguchi O, Takeda T, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13:619-624.
29. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6:463-477.
30. Gustafsson AB, Gottlieb RA. Mechanisms of apoptosis in the heart. J Clin Immunol. 2003;23:447-459.
31. Chen Z, Chua CC, Ho YS, et al. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol. 2001;280:2313-2320.
32. You L, Li L, Xu Q, et al. Postconditioning reduces infarct size and cardiac myocyte apoptosis via the opioid receptor and JAK-STAT signaling pathway. Mol Biol Rep. 2011;38:437-443.
33. Tian Y, Zhang W, Xia D, et al. Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway. J Biomed Sci. 2011;18:53-61.
34. Maiuri C, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8: 741-752.