Total saponins of panax notoginseng enhance VEGF and relative receptors signals and promote angiogenesis derived from rat bone marrow mesenchymal stem cells

Journal of Ethnopharmacology

Volumn 147, Issue 3, 2013, Pages 595-602

  Zheng, Huizhen ^a   Liu, Chen ^a   Ou, Yongfang ^a   Zhang, Yongjuan ^a   Fu, Xuekun ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Bone marrow mesenchymal stem cells; Rat; Total saponins of Panax notoginseng; Vascular endothelial growth factor; Vascular endothelial growth factor receptor

Indexed keywords

MESSENGER RNA; PANAX NOTOGINSENG EXTRACT; SAPONIN DERIVATIVE; TOTAL SAPONIN OF PANAX NOTOGINSENG; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MESENCHYMAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; MALE; MESENCHYMAL STROMAL CELLS; NEOVASCULARIZATION, PHYSIOLOGIC; PANAX NOTOGINSENG; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SAPONINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

PANAX NOTOGINSENG; RATTUS;

EID: 84877626830     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.03.043     Document Type: Article

References (35)

1. G Bernardini, D. Ribatti, and G. Spinetti In vitro and in vivo models to study chemokine regulation of angiogenesis D. D'Ambrosio, F. Sinigaglia.; Cell Migration In Inflammation and Immunity Methods and Protocols. Methods in Molecular Biology™ 239 2003 Humana Press Inc 223 232
2. G Chamberlain, J Fox, B Ashton, and J. Middleton Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Stem Cells 25 2007 2739 2749
3. C. De Vries, J.A. Escobedo, H. Ueno, K. Houck, N Ferrara, and L.T. Williams The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor Science 255 1992 989 991
4. PF Feng, NP Qin, and Q. Qiao Clinical and experimental study of improving left ventricular diastolic function by total saponins of Panax notoginseng Zhongguo Zhong Xi Yi Jie He Za Zhi 17 1997 714 717
5. JH Fu, XZ Li, XH Shang, and JX. Liu Protective effects of saponines of stem and leaf of Panax notoginseng on acute myocardial ischemia in anaesthetic dogs Zhongguo Zhong Yao Za Zhi 31 2006 62 65
6. SB Freedman, and JM. Isner Therapeutic angiogenesis for coronary artery disease Annals of Internal Medicine 136 2002 54 71
7. S Guiducci, M Manetti, E Romano, B Mazzanti, C Ceccarelli, S Dal Pozzo, AF Milia, S Bellando-Randone, G Fiori, ML Conforti, R Saccardi, L Ibba-Manneschi, and M. Matucci-Cerinic Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro Annals of the Rheumatic Diseases 70 2011 21 2011
8. EM Horwitz, PL Gordon, WK Koo, JC Marx, MD Neel, RY McNall, L Muul, and T. Hofmann Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone Proceedings of the National Academy of Sciences of the United States of America 99 2002 8932 8937
9. SJ Hong, JB Wan, Y Zhang, G Hu, HC Lin, SW Seto, YW Kwan, ZX Lin, YT Wang, and SM. Lee Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo Phytotherapy Research 23 2009 677 686
10. Y Iso, JL Spees, C Serrano, B Bakondi, R Pochampally, YH Song, BE Sobel, P Delafontaine, and DJ. Prockop Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment Biochemical and Biophysical Research Communications 354 2007 700 706
11. MN Jameel, and J. Zhang Stem cell therapy for ischemic heart disease Antioxidants & Redox Signaling 13 2010 1879 1897
12. Joseph B. Kearney, Nicholas C. Kappas, Catharina Ellerstrom, Frank W. DiPaola, and Victoria L. Bautch. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis Blood 103 2004 4527 4535
13. Y Liu, J Guo, P Zhang, S Zhang, P Chen, K Ma, and C. Zhou Bone marrow mononuclear cell transplantation into heart elevates the expression of angiogenic factors Microvascular Research 68 2004 156 160
14. X Li, JX Chen, and JJ. Sun Protective effects of Panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat Zhongguo Yao Li Xue Bao 11 1990 26 29
15. H Li, G Chen, and CQ. Deng Effects of plasma containing Buyang Huanwu Decoction and its effective components and total Panax notoginseng saponins on vascular smooth muscle cell proliferation induced by platelet-derived growth factor Zhong Xi Yi Jie He Xue Bao 7 2009 1078 1085
16. KM. Malinda In vivo matrigel migration and angiogenesis assays Methods in Molecular Medicine 78 2003 329 335
17. KM. Malinda In vivo matrigel migration and angiogenesis assay Methods in Molecular Medicine 467 2009 287 294
18. N Nakano, Y Nakai, TB Seo, Y Yamada, T Ohno, A Yamanaka, Y Nagai, M Fukushima, Y Suzuki, T Nakatani, and C. Ide Characterization of conditioned medium of cultured bone marrow stromal cells Neuroscience Letters 483 2010 57 61
19. D Orlic, J Kajstura, S Chimenti, F Limana, I Jakoniuk, F Quaini, B Nadal-Ginard, DM Bodine, A Leri, and P. Anversa Mobilized bone marrow cells repair the infarcted heart, improving function and survival Proceedings of the National Academy of Sciences of the United States of America 98 2001 10344 10349
20. D Orlic, J Kajstura, S Chimenti, DM Bodine, A Leri, and P. Anversa Transplanted adult bone marrow cells repair myocardial infarcts in mice Annals of the New York Academy of Sciences 938 2001 221 229 discussion 229-230
21. DG Phinney, and DJ. Prockop Concise review: mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair - current views Stem Cells 25 2007 2896 2902
22. D Paul, SM Samuel, and N. Maulik Mesenchymal stem cell: present challenges and prospective cellular cardiomyoplasty approaches for myocardial regeneration Antioxidants & Redox Signaling 11 2009 55 1841
23. H Qiang, KZ Wang, ZB Shi, and LH. Fan Panax notoginseng saponins protect rabbit bone marrow stromal cells from hydrogen peroxide-induced apoptosis Zhong Xi Yi Jie He Xue Bao 8 2010 131 137
24. K Shen, L Ji, C Gong, Y Ma, L Yang, Y Fan, M Hou, and Z. Wang Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways Biochemical Pharmacology Jul. 2012 4 [Epub ahead of print]
25. YC Si, JP Zhang, CE Xie, LJ Zhang, and XN. Jiang Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells American Journal of Chinese Medicine 39 2011 999 1013
26. M. Shibuya Role of VEGF-Flt receptor system in normal and tumor angiogenesis Advances in Cancer Research 67 1995 281 316
27. M. Shibuya Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis Journal of Biochemistry and Molecular Biology 39 2006 469 478
28. M. Shibuya, and L. Claesson-Welsh Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis Experimental Cell Research 312 2006 549 560
29. L Wei, JL Fraser, ZY Lu, X Hu, and SP. Yu Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats Neurobiology of Disease 46 2012 635 645
30. L Xu, JT Liu, N Liu, PP Lu, and XM. Pang Effects of Panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells Journal of Ethnopharmacology 137 2011 226 230
31. H Yao, P Shi, Q Shao, and X. Fan Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS Chinese Medicine 6 2011 9
32. LM Yin, X Wang, XD Qian, XJ Lin, XH Chen, and RL. Gao Effects of Panax notoginseng saponins on proliferation and differentiation in NIH3T3 cells Chinese Journal of Integrative Medicine 18 2012 616 620
33. HZ Zheng, H Qiu, and AH. Fan Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro Sheng Li Xue Bao 61 2009 339 346
34. HZ Zheng, and J. Zhao Rat bone marrow mesenchymal stem cells-differentiated endothelial like cells facilitate angiogenesis and the Rho kinase contribution Sheng Li Xue Bao 63 2011 359 366
35. W Zhang, G Chen, and CQ. Deng Effects and mechanisms of total Panax notoginseng saponins on proliferation of vascular smooth muscle cells with plasma pharmacology method Journal of Pharmacy and Pharmacology 64 2012 139 145