Heparin-functionalized nanocapsules: Enabling targeted delivery of antimalarial drugs

Future Medicinal Chemistry

Volumn 5, Issue 7, 2013, Pages 737-739

  Fernàndez Busquets, Xavier ^a,b  

^a CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^b INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

Author keywords

antimalarial; erythrocyte; glycosaminoglycan; heparin; magic bullet; malaria; nanomedicine; nanovector; Plasmodium; targeted drug delivery

Indexed keywords

ANTIBIOTIC AGENT; ANTIMALARIAL AGENT; CHLOROQUINE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARIN; INSECTICIDE; NANOCAPSULE;

ANOPHELES; ANTIGENIC VARIATION; BED NET; BRAIN HEMORRHAGE; DRUG DELIVERY SYSTEM; ERYTHROCYTE; GAMETOCYTE; HUMAN; LIVER CELL; MALARIA; MEMBRANE TRANSPORT; MICROVASCULATURE; NANOMEDICINE; NONHUMAN; PARASITEMIA; PLASMODIUM; PREGNANCY OUTCOME; PRIORITY JOURNAL; REVIEW; VACCINATION;

ANTIMALARIALS; ERYTHROCYTES; HEPARIN; HUMANS; MALARIA; NANOCAPSULES; NANOMEDICINE; PLASMODIUM;

EID: 84877622127     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.13.53     Document Type: Review

References (20)

1. Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature 415(6872), 673-679 (2002).
2. Cowman AF, Crabb BS. Invasion of red blood cells by malaria parasites. Cell 124(4), 755-766 (2006).
3. Rovira-Graells N, Gupta AP, Planet E, et al. Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome Res. 22(5), 925-938 (2012).
4. Griffith KS, Lewis LS, Mali S, Parise ME. Treatment of malaria in the United States: a systematic review. JAMA 297(20), 2264-2277 (2007).
5. WHO. Guidelines for the treatment of malaria. 2nd edition. WHO Press, Geneva, Switzerland (2010).
6. Santos-Magalhaes NS, Mosqueira VCF. Nanotechnology applied to the treatment of malaria. Adv. Drug Deliv. Rev. 62(4-5), 560-575 (2010).
7. Leavy O. Therapeutic antibodies: past, present and future. Nat. Rev. Immunol. 10(5), 297-297 (2010).
8. Yayon A, Ginsburg H. The transport of chloroquine across human erythrocyte membranes is mediated by a simple symmetric carrier. Biochim. Biophys. Acta 686(2), 197-203 (1982).
9. Duncan R, Gaspar R. Nanomedicine(s) under the microscope. Mol. Pharmaceutics 8(6), 2101-2141 (2011).
10. Petersen I, Eastman R, Lanzer M. Drug-resistant malaria: molecular mechanisms and implications for public health. FEBS Lett. 585(11), 1551-1562 (2011).
11. Urbán P, Estelrich J, Cortés A, Fernàndez-Busquets X. A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro. J. Control. Release 151(2), 202-211 (2011).
12. Beeson JG, Andrews KT, Boyle M, et al. Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity. J. Biol. Chem. 282(31), 22426-22436 (2007).
13. Juillerat A, Igonet S, Vigan-Womas I, et al. Biochemical and biophysical characterisation of DBL1a1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum. Mol. Biochem. Parasitol. 170(2), 84-92 (2010).
14. Sheehy TW, Reba RC. Complications of falciparum malaria and their treatment. Ann. Intern. Med. 66(4), 807-809 (1967).
15. Leitgeb AM, Blomqvist K, Cho-Ngwa F, et al. Low anticoagulant heparin disrupts Plasmodium falciparum rosettes in fresh clinical isolates. Am. J. Trop. Med. Hyg. 84(3), 390-396 (2011).
16. Miura Y, Aoyagi S, Kusada Y, Miyamoto K. The characteristics of anticoagulation by covalently immobilized heparin. J. Biomed. Mater. Res. 14(5), 619-630 (1980).
17. Valle-Delgado JJ, Urbán P, Fernàndez-Busquets X. Demonstration of specific binding of heparin to Plasmodium falciparum-infected vs non-infected red blood cells by single-molecule force spectroscopy. Nanoscale doi: 10.1039/C2NR32821F (2013) (Epub ahead of print).
18. Boyle MJ, Richards JS, Gilson PR, Chai W, Beeson JG. Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites. Blood 115(22), 4559-4568 (2010).
19. Delves MJ, Ramakrishnan C, Blagborough AM, Leroy D, Wells TNC, Sinden RE. A high-throughput assay for the identification of malarial transmission- blocking drugs and vaccines. Int. J. Parasitol. 42(11), 999-1006 (2012).
20. WHO. World malaria report (2011). www.who.int/malaria/world-malaria- report-2011/9789241564403-eng.pdf