The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue

Diabetology and Metabolic Syndrome

Volumn 5, Issue 1, 2013, Pages

  Kosacka, Joanna ^a   Koch, Karoline ^a   Gericke, Martin ^a   Nowicki, Marcin ^a   Heiker, John T ^a   Klöting, Ingrid ^b   Stumvoll, Michael ^a   Blüher, Matthias ^a   Klöting, Nora ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Adipose tissue; Atg5; Atg7; Autophagy; Insulin resistance; WOKW

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; CASPASE 3; CHOLESTEROL; GLUCOSE; INSULIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EPIDIDYMIS FAT; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAABDOMINAL FAT; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SUBCUTANEOUS FAT; SUBCUTANEOUS TISSUE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

EID: 84877611062     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-5-23     Document Type: Article

References (27)

1. Autophagy: molecular machinery for self-eating. Yorimitsu T, Klionsky DJ, Cell Death Differ 2005 12 1542 1552 (Pubitemid 41553991)
2. Autophagy and signaling: their role in cell survival and cell death. Codogno P, Meijer AJ, Cell Death Differ 2005 12 1509 1518 (Pubitemid 41553987)
3. Ubiquitin-mediated proteolysis: biological regulation via destruction. Ciechanover A, Orian A, Schwartz AL, Bioessays 2000 22 442 451 (Pubitemid 30308270)
4. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Nedelsky NB, Todd PK, Taylor JP, Biochim Biophys Acta 2008 1782 691 699
5. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y, Nat Rev Mol Cell Biol 2009 10 458 467
6. Autophagy, signaling and obesity. Lavallard VJ, Meijer AJ, Codogno P, Gual P, Pharmacol Res 2012 66 513 525
7. Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Autophagy 2012 8 1 100
8. Autophagy in the pathogenesis of disease. Levine B, Kroemer G, Cell 2008 132 27 42
9. Altered autophagy in human adipose tissues in obesity. Kovsan J, Blüher M, Tarnovscki T, Klöting N, Kirshtein B, Madar L, Shai I, Golan R, Harman-Boehm I, Schön MR, Greenberg AS, Elazar Z, Bashan N, Rudich A, J Clin Endocrinol Metab 2011 96 268 E277
10. Autophagy: a potential link between obesity and insulin resistance. Codogno P, Meijer AJ, Cell Metab 2010 11 449 451
11. Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg (RT1u Haplotype) rat. van den Brandt J, Kovacs P, Klöting I, Metabolism 2000 49 1140 1144
12. Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats. van den Brandt J, Kovacs P, Klöting I, Int J Obes Relat Metab Disord 2002 26 573 576 (Pubitemid 34407272)
13. Nociceptin/orphanin FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome. Cifani C, Kloting I, Morini G, Grandi D, Massi M, Polidori C, Peptides 2009 30 727 734
14. Phenotypic and gene expression differences between DA, BN and WOKW rats. Lange J, Barz T, Ekkernkamp A, Wilke B, Klöting I, Follak N, PLoS One 2012 7 38981
15. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Kloting N, Bluher M, Kloting I, Diabetes Metab Res Rev 2006 22 146 154
16. Genetic dissection of the syndrome X in the rat. Kovacs P, van den Brandt J, Klöting I, Biochem Biophys Res Commun 2000 269 600 605
17. Autophagy in adipose tissue. Maixner N, Kovsan J, Harman-Boehm I, Blüher M, Bashan N, Rudich A, Obes Facts 2012 5 710 721
18. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Tanida I, Mizushima N, Kiyooka M, Ohsumi M, Ueno T, Ohsumi Y, Kominami E, Mol Biol Cell 1999 10 1367 1379 (Pubitemid 29230896)
19. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Yang L, Li P, Fu S, Calay ES, Hotamisligil GS, Cell Metab 2010 11 467 478
20. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T, EMBO J 2000 19 5720 5728
21. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T, J Cell Sci 2004 117 2805 2812 (Pubitemid 38997262)
22. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Jansen HJ, van Essen P, Koenen T, Joosten LA, Netea MG, Tack CJ, Stienstra R, Endocrinology 2012 153 5866 5874
23. Cytosolic LC3 ratio as a quantitative index of macroautophagy. Kadowaki M, Karim MR, Methods Enzymol 2009 452 199 213
24. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S, Nature 2009 461 654 658
25. Autophagy in regulation of Toll-like receptor signaling. Into T, Inomata M, Takayama E, Takigawa T, Cell Signal 2012 24 1150 1162
26. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR, Proc Natl Acad Sci U S A 2011 108 17396 17401
27. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. Alkhouri N, Gornicka A, Berk MP, Thapaliya S, Dixon LJ, Kashyap S, Schauer PR, Feldstein AE, J Biol Chem 2010 285 3428 3438