Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion

Environmental Toxicology

Volumn 28, Issue 6, 2013, Pages 332-341

  Wei, Wei ^a   Gao, Yanhui ^a   Wang, Cheng ^a   Zhao, Lijun ^a   Sun, Dianjun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Ameloblasts; Dental enamel matrix; Endoplasmic reticulum stress; Fluoride; Kallikrein 4; LS8 cells; Matrix metalloproteinase 20

Indexed keywords

AMELOBLASTS; DENTAL ENAMELS; ENDOPLASMIC RETICULUM STRESS; FLUORIDE; KALLIKREIN-4;

CELL CULTURE; CELL MEMBRANES; ENAMELS; FLUORINE COMPOUNDS; MATRIX ALGEBRA; PHYSIOLOGY; PLANTS (BOTANY); SIGNALING; TOOTH ENAMEL; TRANSCRIPTION FACTORS;

BIOSYNTHESIS;

ENAMEL PROTEIN; FLUORIDE SODIUM; GLUCOSE REGULATED PROTEIN 78; KALLIKREIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 20; TRANSCRIPTION FACTOR; X BOX BINDING PROTEIN 1;

BIOLOGICAL UPTAKE; CELL ORGANELLE; CYTOLOGY; DENTAL HEALTH; DOSE-RESPONSE RELATIONSHIP; ENAMEL; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; FLUORIDE; GENE EXPRESSION; HEALTH IMPACT; METABOLISM; POLLUTION EXPOSURE; POLYMERASE CHAIN REACTION; SECRETION;

AMELOBLAST; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENAMEL; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; ENZYME SYNTHESIS; FLUOROSIS; GENE EXPRESSION; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

AMELOBLASTS; ANIMALS; CELL LINE; CELL PROLIFERATION; DENTAL ENAMEL PROTEINS; ENDOPLASMIC RETICULUM STRESS; FLUOROSIS, DENTAL; KALLIKREINS; MATRIX METALLOPROTEINASE 20; MICE; SODIUM FLUORIDE; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84877599957     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20724     Document Type: Article

References (38)

1. Aoba T, Moreno EC, Tanabe T, Fukae M. 1990. Effects of fluoride on matrix proteins and their properties in rat secretory enamel. J Dent Res 69: 1248-1255.
2. Bartlett JD, Simmer JP, Xue J, Margolis HC, Moreno EC. 1996. Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ. Gene 183: 123-128.
3. Beniash E, Skobe Z, Bartlett JD. 2006. Formaion of the dentino-enamelinterface in enamelysin(MMP-20) deficient mouse incisors. Eur J Oral Sci 114: 24-29.
4. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. 2000. Dynamic interaction of Bip and ER stress transducers in the unfolded protein response. Nat Cell Biol 2: 326-332.
5. Bronckers AL, Lyaruu DM, DenBesten PK. 2009. The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis. J Dent Res 88: 877-893.
6. Caterina JJ, Skobe Z, Shi J, Ding Y, Simmer JP, Birkedal-Hansen H, Bartlett JD. 2002. Enamelysin (matrixmetalloproteinase 20)-deficien mice display an amelogenesis imperfecta phenotype. J Biol Chem 277: 49598-49604.
7. DenBesten PK, Yan Y, Featherstone JD, Hilton JF, Smith CE, Li W. 2002. Effects of fluoride on rat dental enamel matrix proteinases. Arch Oral Biol 47: 763-770.
8. Fincham AG, Moradian-Oldak J, Simmer JP. 1999. The structural biology of the developing dental enamel matrix. J Struct Biol 126: 270-299.
9. Gao CN, Wang Q, Wu HM. 2008. Effect of overdose fIuoride on the expression of amelogenin in rat mandibular incisor. Int J Stomatol 35: 233-235.
10. Gerlach RF, de Souza AP, Cury JA, Line SR. 2000. Fluoride effect on the activity of enamel matrix proteinases in vitro. Eur J Oral Sci 108: 48-53.
11. Hendershot LM. 2004. The ER function BiP is a master regulator of ER function. Mt Sinai J Med 71: 289-297.
12. Hu JC, Chun YH, Al Hazzazzi T, Simmer JP. 2007. Enamel formation and amelogenesis imperfecta. Cells Tissues Organs 186: 78-85.
13. Hu JC, Sun X, Zhang C, Liu S, Bartlett JD, Simmer JP. 2002. Enamelysin and kallikrein-4 mRNA expression in developing mouse molars. Eur J Oral Sci 110: 307-315.
14. Kim JW, Simmer JP, Hart TC, Hart PS, Ramaswami MD, Bartlett JD, Hu JC. 2005. MMP-20 mutaion in autosomal recessive pigmented hypomaturation amelogenesis imperfecta. J Med Genet 42: 271-275.
15. Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML, Nguyen L, Urano F, Bartlett JD. 2005. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem 280: 23194-23202.
16. Lee AS. 2001. The glucose-regulated proteins: Stress induction and clinical applications. Trends Biochem Sci 26: 504-510.
17. Lee AS. 2007. GRP78 induction in cancer: Therapeutic andprognostic implications. Cancer Res 67: 3496-3499.
18. Lu Y, Papagerakis P, Yamakoshi Y, Hu JC, Bartlett JD, Simmer JP. 2008. Functions of KLK4 and MMP-20 in dental enamel formation. Biol Chem 389: 695-700.
19. Ma Y, Hendershot LM. 2004. ER chaperone functions during normal and stress conditions. J Chem Neuroanat 28: 51-65.
20. Nagano T, Oida S, Ando H, Gomi K, Arai T, Fukae M. 2003. Relative levels of mRNA encoding enamel proteins in enamel organ epithelia and odontoblasts. J Dent Res 82: 982-986.
21. Ni M, Lee AS. 2007. ER chaperones in mammalian development and human diseases. FEBS Lett 581: 3641-3651.
22. Orrenius S, Zhivotovsky B, Nicotera P. 2003. Regulation of cell death: The calcium-apoptosis link. Nat Rev Mol Cell Biol 4: 552-565.
23. Ozdemir D, Hart PS, Ryu OH, Choi SJ, Ozdemir-Karatas M, Firatli E, Piesco N, Hart TC. 2005. MMP-20 active-site mutation in hypomaturation amelogenesis imperfecta. J Dent Res 84: 1031-1035.
24. Rao RV, Bredesen DE. 2004. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 16: 653-662.
25. 2+ liaison. Sci STKE (215): re1.
26. Robinson C, Kirkham J. 1990. The effect of fluoride on the developing mineralized tissues. J Dent Res 69: 685-691.
27. Robinson C, Kirkham J, Hallsworth AS. 1988. Volume distribution and concentration of protein, mineral and water in developing bovine enamel. Arch Oral Biol 33: 159-162.
28. Robinson C, Connell S, Kirkham J, Brookes SJ, Shore RC, Smith AM. 2004. The effect of fluoride on the developing tooth. Caries Res 38: 268-276.
29. Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
30. Rutkowski DT, Kaufman RJ. 2004. A trip to the ER: Coping with stress. Trends cell Biol 14: 20-28.
31. Schroder M, Kaufman RJ. 2005. ER stress and the unfolded protein response. Mutat Res 569: 29-63.
32. Sharma R, Tsuchiya M, Bartlett JD. 2008. Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion. Environ Health Perspect 116: 1142-1146.
33. Shen X, Zhang K, Kaufman RJ. 2004. The unfolded protein response: A stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat 28: 79-92.
34. Simmer JP, Hu JC. 2002. Expression, strcture, and function of enamel proteinases. Connect Tissue Res 43: 441-449.
35. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD. 1998. Purification, characterization, and cloning of enamel matrix serine proteinase 1. J Dent Res 77: 377-386.
36. Stephanopoulos G, Garefalaki ME, Lyroudia K. 2005. Genes and related proteins involved in Amelogenesis imperfecta. J Dent Res 84: 1117-1126.
37. Wright JT, Hart TC, Hart PS, Simmons D, Suggs C, Daley B, Simmer J, Hu J, Bartlett JD, Li Y, Yuan ZA, Seow WK, Gibson CW. 2009. Human and mouse enamel phenotypes resultion from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4. Cells Tissues Organs 189: 224-229.
38. Zhang Y, Yan Q, Li W, Denbesten PK. 2006. Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro. Eur J Oral Sci 114: 105-110.