Molecular mechanism of inflammatory response in mouse liver caused by exposure to CeCl3

Environmental Toxicology

Volumn 28, Issue 6, 2013, Pages 349-358

  Li, Na ^a   Cheng, Jie ^a   Cheng, Zhe ^a   Hu, Renping ^a   Cai, Jingwei ^a   Gao, Guodong ^a   Cui, Yaling ^a   Wang, Ling ^a   Hong, Fashui ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Cerium; Histopathological changes; Inflammatory cytokines; Liver; Mice

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGICAL CHANGES; INFLAMMATORY CYTOKINES; MICE; PROTEIN EXPRESSION LEVELS; REVERSE TRANSCRIPTASE- POLYMERASE CHAIN REACTION;

AMINO ACIDS; BODY FLUIDS; CERIUM; LIVER; MACROPHAGES; PATHOLOGY; PHOSPHATASES;

LIVING SYSTEMS STUDIES;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CERIUM; CERIUM CHLORIDE; CHOLINESTERASE; CYTOSOL AMINOPEPTIDASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; INTERLEUKIN 2; LACTATE DEHYDROGENASE; MESSENGER RNA; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIBODY; BIOACCUMULATION; BIOCHEMISTRY; BODY MASS; CERIUM; CHLORIDE; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOASSAY; MOLECULAR ANALYSIS; POLLUTION EFFECT; POLLUTION EXPOSURE; POLYMERASE CHAIN REACTION; RODENT; SERUM; TUMOR;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEPATITIS; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY CELL; LIVER FUNCTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ALANINE TRANSAMINASE; ANIMALS; CERIUM; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN M; INFLAMMATION; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

MUS;

EID: 84877597484     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20727     Document Type: Article

References (41)

1. Aderem A. 2003. Phagocytosis and the inflammatory response. J Infect Dis 187: S340-S345.
2. Calandra T, Roger T. 2003. Macrophage migration inhibitory factor: A regulator of innate immunity. Nat Rev Immunol 3: 791-800.
3. Chen ZY. 1999. Reflection on the biological effects of rare earth and the cumulative impacts of its agricultural application. Rural Eco-Environment 15: 44-48.
4. Chen TL, Chang CC, Lin YL, Ueng YF, Chen RM. 2009. Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells. Toxicol Appl Pharmacol 240: 15-25.
5. Cheng J, Cheng Z, Gong XL, Cui YL, Hu RP, Cai JW, Hong FS. 2011a. Splenocyte apoptotic pathway in mice following oral exposure to cerium trichloride. Chemosphere 83:612-617.
6. Cheng Z, Li N, Cheng J, Hu RP., Gao GD, Cui YL, Gong XL, Wang L, Hong FS. 2011b. Signal pathway of hippocampal apoptosis and cognitive impairment of mice caused by cerium chloride. Environ Toxicol DOI 10.1002/tox. 20696, in press.
7. De Gusseme B, Du Laing G, Hennebel T, Renard P, Chidambaram D, Fitts JP, Bruneel E, Van Driessche I, Verbeken K, Boon N, Verstraete W. 2010. Virus removal by biogenic cerium. Environ Sci Technol 44: 6350-6356.
8. Evans CH. 2003. Biochemistry of the Lanthanides. New York: Plenum Press.
9. Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA. 2004. Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation. Shock 22: 57-62.
10. Fei M, Li N, Ze Y, Liu J, Wang S, Gong X, Duan Y, Zhao X, Wang H, Hong F. 2011a. The mechanism of liver injury in mice caused by lanthanides. Biol Trace Elem Res DOI 10.1007/s12011-010-8698-x, in press.
11. Fei M, Li N, Ze YG, Liu J, Gong XL, Duan YM, Zhao XY, Wang H, Hong FS. 2011b. Oxidative stress in the liver of mice caused by intraperitoneal injection with lanthanides. Biol Trace Elem Res 139: 72-80.
12. Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: Evolutionarily conservedmediators of immune responses. Annu Rev Immunol 16: 225-260.
13. Huang SF, Li ZY, Wang XQ, Wang QX, Hu FF. 2010. Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster. Ecotoxicol Environ Saf 73: 89-93.
14. Iwasaki A Medzhitov R. 2004. Toll-like receptor control of adaptive immune responses. Nat Immunol 5: 987-995.
15. Jones BW, Means TK, Heldwein KA, Keen MA, Hill PJ, Belisle JT, Fenton MJ. 2001. Different Toll-like receptor agonists induce distinct macrophage responses. J Leukoc Biol 69: 1036-1044.
16. Ke LD, Chen Z, Yung WK. 2000. A reliability test of standard-based quantitative PCR: Exogenous vs endogenous standards. Mol Cell Probes 14: 127-135.
17. Li Q, Verma IM. 2002. NF-κB regulation in the immune system. Nat Rev Immunol 2: 725-734.
18. Li N, Wang SS, Liu J, Ma LL, Duan YM, Hong FS. 2010. The oxidative damage in lung of mice caused by lanthanoide. Biol Trace Elem Res 134: 68-78.
19. Liu Y, Chen D, Chen AJ, Liu B, Sun SY, Nie YX. 2001. Subchronic toxicity of lanthanum nitrate on liver of rats. J Chin Rare Earth Soc 19: 167-170 (abstract in English).
20. Liu W, Saint DA. 2002. Validation of a quantitative method for real time PCR kinetics. Biochem Biophys Res Commun 294: 347-353.
21. Liu J, Li N, Ma LL, Duan YM, Wang J, Zhao XY, Wang SS, Wang H, Hong FS. 2010. Oxidative injury in the mouse spleen caused by lanthanides. J Alloys Compd 489: 708-713.
22. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method. Methods 25: 402-408.
23. Ma JY, Zhao H, Mercer RR, Barger M, Rao M, Meighan T, Schwegler-Berry D, Castranova V, Ma JK. 2010. Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats. Nanotoxicology PMID 20925443.
24. Nair RR, Preeta R, Smitha G, Adiga I. 2003. Variation in mitogenic response of cardiac and pulmonary fibroblasts to cerium. Biol Trace Elem Res 94: 237-246.
25. Nakamura Y, Tumura Y, Tonogai Y, Shibata T, Ito Y. 1997. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. Fundam Appl Toxicol. 37: 106-116.
26. Nathan CF. 1987. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products ofmacrophages and lymphocytes. J Clin Invest 80: 1550-1560.
27. National Institutes of Health (NIH). 1996. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press.
28. 3+ on the activities of ATPase of hepatocytes. Chin Rare Earths 22: 35-37 (abstract in English).
29. Siebenlist U, Franzoso G, Brown K. 1994. Structure, regulation and function of NF-κB. Annu Rev Cell Biol 10: 405-455.
30. Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P, Rivero F. 2006. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryot Cell 5: 1648-1663.
31. Vives-Pi M, Somoza N, Fernandez- Alvarez J, Vargas F, Caro P, Alba A, Gomis R, Labeta MO, Pujol-Borrell R. 2003. Evidence of expression of endotoxin receptors CD14. Toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endofoxin (LPS) in islet beta cells. J Clin Exp Immunol 133: 208-218.
32. Wang K, Cheng Y, Yang Li XR. 2003. Cell responses to lanthanides and potential pharmacological actions of lanthanides. Met Ions Biol Syst 40: 707-751.
33. Xu X, Zhu W, Wang Z, Witkamp GJ. 2002. Distribution of rare earths and heavy metals in field-grown maize after application of rare earth-containing fertilizers. Sci Total Environ 293: 97-105.
34. Yang W, Wang T, Lei H, Yang Y. 1999. Study on the hepatic toxicity of cerous nitrate in rats. J Hyg Res 28: 91-92 (abstract in English).
35. Yuan BJ, Liao MY, Li B. 2007. Drug Toxicological Method and Technic. Beijing: Chemical Industry Press. pp 215-217 (in Chin).
36. 3. Biol Trace Elem Res DOI 10.1007/s12011-010-8880-1, in press.
37. Zhang S, Shan X. 2001. Speciation of rare earth elements in soil and accumulation by wheat with rare earth fertilizer application. Environ Pollut 112: 395-405.
38. Zhang H, Feng J, Zhu WF. 1999. Characteristic of rare earth distribution in biologicol chains of rare earth-rich background regions. J Rare Earths 17: 356-358.
39. Zhang ZG, Shen XY, Xu XL, Wu AF. 2004. Effects of cerium nitrate on learning-memmory and antioxidantion of rats. J Zhejiang Nor Univ 24: 167-170 (abstract in English).
40. Zhao H, Cheng Z, Hu R, Chen J, Hong M, Zhou M, Gong X, Wang L, Hong F. 2010. Oxidative injury in the brain of mice caused by lanthanides. Biol Trace Elem Res DOI 10.1007/s12011-010-8759-1.
41. Zhu WF, Xu SQ, Shao PP, Zhang H, Feng J, Wu DL, Yang WJ. 1997. Investigation on intake allowance of rare earth-A study on bio-effect of rare earth in South Jiangxi. Chin Environ Sci 17: 64-66.