Discovery of natural estrogen receptor modulators with structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3329-3333

  Cao, Xianwen ^a   Jiang, Jing ^a   Zhang, Shoude ^a,b   Zhu, Lili ^a   Zou, Juan ^c   Diao, Yanyan ^a   Xiao, Weilie ^c   Shan, Lei ^d   Sun, Handong ^c   Zhang, Weidong ^b,d   Huang, Jin ^a   Li, Honglin ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Estrogen receptor; Molecular docking; Natural product; Virtual screening

Indexed keywords

CENTCHROMAN; CYCLOARTANE TRITERPENOID; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FARNESOID X RECEPTOR; METHIONINE; NATURAL PRODUCT; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DOCKING; SCHISANDRA; SCHISANDRA GLAUCESCENS DIELS; SIMULATION; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PROTEIN BINDING; SCHISANDRA; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

SCHISANDRA GLAUCESCENS;

EID: 84877583263     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.105     Document Type: Article

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