Structure-activity relationships in aminosterol antibiotics: The effect of stereochemistry at the 7-OH group

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3377-3381

  Tessema, Tsemre Dingel ^a   Gassler, Frank ^a   Shu, Youheng ^a,b   Jones, Stephen ^a,c   Selinsky, Barry S ^a  

^a VILLANOVA UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c IsoSciences LLC   (United States)

Author keywords

Aminosterols; Antimicrobial; Biocidal compounds; Squalamine

Indexed keywords

ANTIBIOTIC AGENT; HYDROXYL GROUP; POLYAMINE; SPERMINE; SQUALAMINE; STEROL DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PSEUDOMONAS AERUGINOSA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CHOLESTANOLS; ESCHERICHIA COLI; LIPOSOMES; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; SPERMIDINE; SPERMINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA;

EID: 84877582919     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.094     Document Type: Article

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