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Volumn 23, Issue 11, 2013, Pages 3244-3247
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Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent
a
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Author keywords
11 HSD1; Diabetes; Fibrates; Molecular docking
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Indexed keywords
11BETA HYDROXYSTEROID DEHYDROGENASE 1;
2 (4 CHLOROPHENOXY) 2 METHYL N (1H TETRAZOL 5 YL)PROPANAMIDE;
ANTIDIABETIC AGENT;
CARBENOXOLONE;
CLOFIBRATE;
CLOFIBRIC ACID;
CLOFIBRIC ACID DERIVATIVE;
GLUCOSE;
NICOTINAMIDE;
NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;
TETRAZOLE DERIVATIVE;
UNCLASSIFIED DRUG;
ACUTE TOXICITY;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTIDIABETIC ACTIVITY;
ARTICLE;
CARBON NUCLEAR MAGNETIC RESONANCE;
COMPUTER MODEL;
CONTROLLED STUDY;
DRUG BINDING SITE;
DRUG DESIGN;
DRUG METABOLISM;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME ACTIVITY;
ENZYME INHIBITION;
ENZYME SUBUNIT;
EXPERIMENTAL MODEL;
GLUCOSE BLOOD LEVEL;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
LD 50;
LIGAND BINDING;
MOLECULAR DOCKING;
NON INSULIN DEPENDENT DIABETES MELLITUS;
NONHUMAN;
PROTON NUCLEAR MAGNETIC RESONANCE;
RAT;
SINGLE DRUG DOSE;
SUPRAMOLECULAR CHEMISTRY;
X RAY DIFFRACTION;
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1;
ANIMALS;
BINDING SITES;
BLOOD GLUCOSE;
CATALYTIC DOMAIN;
CLOFIBRIC ACID;
CRYSTALLOGRAPHY, X-RAY;
DIABETES MELLITUS, EXPERIMENTAL;
DRUG EVALUATION, PRECLINICAL;
HUMANS;
HYDROGEN BONDING;
HYPOGLYCEMIC AGENTS;
MICE;
MOLECULAR DOCKING SIMULATION;
RATS;
STRUCTURE-ACTIVITY RELATIONSHIP;
TETRAZOLES;
RATTUS;
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EID: 84877580870
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.122 Document Type: Article |
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Times cited : (26)
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References (15)
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