Deep dermal fibroblast profibrotic characteristics are enhanced by bone marrow-derived mesenchymal stem cells

Wound Repair and Regeneration

Volumn 21, Issue 3, 2013, Pages 448-455

  Ding, Jie ^a   Ma, Zengshuan ^a   Shankowsky, Heather A ^a   Medina, Abelardo ^a   Tredget, Edward E ^a,b  

^a Wound Healing Research Group   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; MESSENGER RNA; STROMAL CELL DERIVED FACTOR 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA;

ABDOMINOPLASTY; ARTICLE; BONE MARROW; BURN; BURN PATIENT; FIBROBLAST; FIBROSIS; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; IN VITRO STUDY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; SKIN INJURY;

ADULT; BURNS; CELL PROLIFERATION; CELLS, CULTURED; CICATRIX, HYPERTROPHIC; COLLAGEN; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; STEM CELL TRANSPLANTATION; WOUND HEALING;

EID: 84877580254     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/wrr.12046     Document Type: Article

References (31)

1. Niessen FB, Spauwen PH, Schalkwijk J, Kon M,. On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 1999; 104: 1435-1458.
2. Singer AJ, Clark RAF,. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746.
3. Hersch SJ,. The early management of the burn wound and observations on hypertrophic scarring. With special reference to the deep dermal level and hypertrophic scarring. S Afr J Surg 1994; 32: 1-4.
4. Monstrey S, Hoeksema H, Verbelen J, Pirayesh A, Blondeel P,. Assessment of burn depth and burn wound healing potential. Burns 2008; 34: 761-769.
5. Dunkin CS, Pleat JM, Gillespie PH, Tyler MP, Roberts AH, McGrouther DA,. Scarring occurs at a critical depth of skin injury: precise measurement in a graduated dermal scratch in human volunteers. Plast Reconstr Surg 2007; 119: 1722-1732.
6. Bombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA, et al. What is the prevalence of hypertrophic scarring following burns? Burns 2003; 29: 299-302.
7. Kuo YR, Wang CT, Cheng JT, Wang FS, Chiang YC, Wang CJ,. Bone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetes. Plast Reconstr Surg 2011; 128: 872-880.
8. Kim CH, Lee JH, Won JH, Cho MK,. Mesenchymal stem cells improve wound healing in vivo via early activation of matrix metalloproteinase-9 and vascular endothelial growth factor. J Korean Med Sci 2011; 26: 726-733.
9. Ma K, Liao S, He L, Lu J, Ramakrishna S, Chan CK,. Effects of nanofiber/stem cell composite on wound healing in acute full-thickness skin wounds. Tissue Eng Part A 2011; 17: 1413-1424.
10. Fathke C, Wilson L, Hutter J, Kapoor V, Smith A, Hocking A, et al. Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair. Stem Cells 2004; 22: 812-822.
11. Deng J, Zou ZM, Zhou TL, Su YP, Ai GP, Wang JP, et al. Bone marrow mesenchymal stem cells can be mobilized into peripheral blood by G-CSF in vivo and integrate into traumatically injured cerebral tissue. Neurol Sci 2011; 32: 641-651.
12. Yang Y, Rossi FM, Putnins EE,. Periodontal regeneration using engineered bone marrow mesenchymal stromal cells. Biomaterials 2010; 31: 8574-8582.
13. Wu Y, Wang J, Scott PG, Tredget EE,. Bone marrow-derived stem cells in wound healing: a review. Wound Repair Regen 2007; 15 (Suppl. 1): S18-S26.
14. Chen Y, Xiang LX, Shao JZ, Pan RL, Wang YX, Dong XJ, et al. Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver. J Cell Mol Med 2010; 14 (6B): 1494-1508.
15. Chen L, Tredget EE, Wu PY, Wu Y,. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 2008; 3: e1886.
16. Crisostomo PR, Wang M, Markel TA, Lahm T, Abarbanell AM, Herrmann JL, et al. Stem cell mechanisms and paracrine effects: potential in cardiac surgery. Shock 2007; 28: 375-383.
17. Jeon YK, Jang YH, Yoo DR, Kim SN, Lee SK, Nam MJ,. Mesenchymal stem cells' interaction with skin: wound-healing effect on fibroblast cells and skin tissue. Wound Repair Regen 2010; 18: 655-661.
18. Laco F, Kun M, Weber HJ, Ramakrishna S, Chan CK,. The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture. J Dermatol Sci 2009; 55: 150-160.
19. Wang J, Dodd C, Shankowsky HA, Scott PG, Tredget EE,. Deep dermal fibroblasts contribute to hypertrophic scarring. Lab Invest 2008; 88: 1278-1290.
20. Tredget EE, Shen YJ, Liu G, Forsyth N, Smith C, Robertson Harrop A, et al. Regulation of collagen synthesis and messenger RNA levels in normal and hypertrophic scar fibroblasts in vitro by interferon alfa-2b. Wound Repair Regen 1993; 1: 156-165.
21. Lennon DP, Haynesworth SE, Arm DM, Baber MA, Caplan AI,. Dilution of human mesenchymal stem cells with dermal fibroblasts and the effects on in vitro and in vivo osteochondrogenesis. Dev Dyn 2000; 219: 50-62.
22. Hildebrandt C, Büth H, Thielecke H,. Influence of cell culture media conditions on the osteogenic differentiation of cord blood-derived mesenchymal stem cells. Ann Anat 2009; 191: 23-32.
23. Bell E, Ivarsson B, Merrill C,. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci U S A 1979; 76: 1274-1278.
24. Wang JF, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE,. Fibrocytes from burn patients regulate the activities of fibroblasts. Wound Repair Regen 2007; 15: 113-121.
25. Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, et al. Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS). Wound Rep Regen 2011; 19: 568-578.
26. Stadelmann WK, Digenis AG, Tobin GR,. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 1998; 176 (2A Suppl.): 26S-38S.
27. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS,. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res 2004; 299: 465-475.
28. Honardoust D, Ding J, Varkey M, Shankowsky HA, Tredget EE,. Deep dermal fibroblasts refractory to migration and decorin-induced apoptosis contribute to hypertrophic scarring. J Burn Care Res 2012; 33: 668-677.
29. Yamaguchi R, Takami Y, Yamaguchi Y, Shimazaki S,. Bone marrow-derived myofibroblasts recruited to the upper dermis appear beneath regenerating epidermis after deep dermal burn injury. Wound Repair Regen 2007; 15: 87-93.
30. Kurita M, Okazaki M, Kaminishi-Tanikawa A, Niikura M, Takushima A, Harii K,. Differential expression of wound fibrotic factors between facial and trunk dermal fibroblasts. Connect Tissue Res 2012; 53: 349-354.
31. Varkey M, Ding J, Tredget EE,. Differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar. Biomaterials 2011; 32: 7581-7591.