Antimicrobial activity of newly synthesized methylsulfanyl- triazoloquinazoline derivatives

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 6, 2013, Pages 790-797

  Al Salahi, Rashad ^a   Marzouk, Mohamed ^a,c   Awad, Ghada ^b   Al Omar, Mohamed ^a   Ezzeldin, Essam ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Chemistry of Natural and Microbial Products   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

1,2,4 triazoloquinazoline; antimicrobial; ciprofloxacin; ketoconazole

Indexed keywords

CIPROFLOXACIN; KETOCONAZOLE; METHYLSULFANYLTRIAZOLOQUINAZOLINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; FUNGI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MESYLATES; MICROBIAL SENSITIVITY TESTS; QUINAZOLINES;

EID: 84877578248     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12039     Document Type: Article

References (30)

1. Martin YC, Austel KE,. Paths to Better and Safer Drugs, Modern Drug Research. New York: Marcel Dekker, 1989: 243.
2. Roth HJ, Fenner H,. Arzneistoffe, 3rd edn. Stuttgart: Deutscher Apotheker Verlag, 2000: 51.
3. Harris CR, Thorarensen A,. Advances in the discovery of novel antibacterial agents during the year 2002. Curr Med Chem 2004; 11: 2213-2243.
4. Andries K, et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 2005; 307: 223-226.
5. Vangapandu S, et al. Ring-substituted quinolines as potential antituberculosis agents. Bioorg Med Chem 2004; 12: 2501-2508.
6. Carta A, et al. Anti-mycobacterial activity of quinolones. Triazoloquinolones a new class of potent anti-mycobacterial agents. Anti Infect Agents Med Chem 2008; 7: 134-147.
7. Wolfe JF, et al. Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones. J Med Chem 1990; 33: 161-166.
8. Xia Y, et al. Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones. Bioorg Med Chem Lett 2001; 11: 1193-1196.
9. Kenichi O, et al. Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives. J Med Chem 1985; 28: 568-576.
10. Buchanan JG, Sable HZ,. In:, Thyagarajan BS, ed. Selective Organic Transformations. New York: Wiley-InterScience, 1972: 1-95.
11. Lyle FR,. US Pat. 5973257. Chem. Abstr. 1985; 65: 2.
12. Birendra NG, et al. Quinoline-based fused heterocyclic systems are found as potential anticancer. J Heterocycl Chem 1984; 21: 1225-1229.
13. Kothari PJ, et al. Synthesis of some new 5-methyl-2-benzoxazolinone derivatives and investigation on their analgesic-antiinflammatory activities. J Heterocycl Chem 1980; 17: 1369-1372.
14. Sengupta AK, Misra HK,. Studies on potential pesticides 13 Synthesis and evaluation of S-(3-substituted phenoxymethyl-4-aryl/cyclohexyl-4H-1,2,4-triazol- 5-yl)-2-mercaptomethyl benzimidazoles for anti-bacterial and insecticidal activities. J Indian Chem Soc 1981; 8: 508.
15. Sarmah SC, Bahel SC,. Synthesis of aryloxy/aryl acetyl thiosemicarbazides, substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and related compounds as potential fungicides. J Indian Chem Soc 1982; 59: 877-880.
16. Francis JE, et al. Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists. J Med Chem 1988; 31: 1014-1020.
17. Kim Y-C, et al. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) having high potency at the human A2B and A3 receptor subtypes. J Med Chem 1998; 41: 2835-2845.
18. 2A receptor antagonists. Farmaco 2001; 56: 87-90.
19. Francis JE, et al. Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem 1991; 34: 281-290.
20. Alagarsamy V, et al. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg Med Chem 2007; 15: 4009-4015.
21. Alagarsamy V, et al. Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents. Bioorg Med Chem Lett 2005; 15: 1877-1880.
22. Al-Salahi R, et al. A new series of 2-alkoxy(aralkoxy)-[1,2,4]triazolo[1, 5-a]quinazolin-5-ones as adenosine receptor antagonists. Chem Pharm Bull 2011; 59: 730-733.
23. Al-Salahi R, Geffken D,. Synthesis of novel 2-alkoxy(aralkoxy)-4H-[1,2,4] triazolo[1,5-a]quinazolin-5-ones starting with dialkyl-N-cyanoimidocarbonates. J Heterocycl Chem 2011; 48: 656-662.
24. Al-Salahi R, Geffken D,. Novel synthesis of 2-alkoxy(aralkoxy)-5- chloro[1,2,4]triazolo [1,5-a]quinazoline and their derivatives. Heterocycles 2010; 81: 1843-1859.
25. Al-Salahi R, Geffken D,. Synthesis and reactivity of [1,2,4]triazolo- annelated quinazolines. Molecules 2010; 15: 7016-7034.
26. Jantova S, et al. Anti-microbial activity of some substituted triazoloquinazolines. Folia Microbiol 2005; 50: 90-94.
27. Scott AC,. Laboratory control of antimicrobial therapy. In:, Collee JG, et al. eds. Practical Medical Microbiology, 13th edn. Edinburgh: Churchill Livingstone, 1989: 161-181.
28. Perez C, et al. An antibiotic assay by the agar well diffusion method. Acta Biol Med Exp 1990; 15: 113-115.
29. Al-Salahi R, Geffken D,. 2-Methylsulfanyl-4H-[1,2,4]triazolo[1,5-a] quinazolin-5-one and derivatives. Synth Commun 2011; 41: 3512-3523.
30. Armitage P,. Statistical Methods in Medicinal Research. Oxford: Blackwell Scientific, 1971.