Synthesis and pharmacological investigation of novel 1-substituted-4- phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H 1-antihistaminic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 7, 2005, Pages 1877-1880

  Alagarsamy, Veerachamy ^a   Giridhar, Rajani ^b   Yadav, Mangai Ram ^b  

^a Periyar College of Pharmaceutical Sciences for Girls   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Antihistamine; Pyrimidine; Quinazoline; Triazole; Triazoloquinazoline

Indexed keywords

1 METHYL 4 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINAZOLIN 5(4H) ONE; 2 HYDRAZINO 3 PHENYLQUINAZOLIN 4(3H) ONE; ANILINE; CARBON; CETIRIZINE; CHLORPHENIRAMINE MALEATE; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HYDRAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; CYCLIZATION; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; SEDATION;

ANIMALIA; CAVIA;

EID: 15044350987     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.016     Document Type: Article

References (19)

1. K. Peat Clin. Exp. Allergy 24 1994 797
2. P. Bummy, S. Chin, and R.J. Rona Br. Med. J. 300 1990 1306
3. T. Naligiami, H. Itaya, T. Tominga, H. Yamaki, S. Hisamatsu, and O. Nakagomi Lancet 343 1994 121
4. F.E.R. Simons, and K.J. Simons N. Engl. J. Med. 59 1994 4
5. 1-Receptor Antagonists 1985 Musby-year book, Inc. St. Louis p 856
6. A.A. Carr, and D.R. Meyer Arzneim.-Forsch./Drug Res. 32 1982 157
7. M.K. Mc Call, N. Nair, S. Wong, R.G. Townley, D. Lang, and S.J. Sweiss J. Allergy Clin. Immunol. 75 1985 168
8. N. Chirungsrilerd, K.I. Frukawa, T. Ohta, S. Nozoe, and Y. Yohazumi Eur. J. Pharmacol. 139 1987 235
9. Wade, J. J. U.S. Patent 4,528,288
10. Chem. Abstr. 104 1986 5889
11. West, W. R.; July, W. R. Eur. Patent 34,529
12. Chem. Abstr. 96 1982 20114
13. V. Alagarsamy, R. Venkatesaperumal, S. Vijayakumar, T. Angayarkanni, P. Pounammal, S. Senthilganesh, and S. Kandeeban Pharmazie 57 2002 306
14. V. Alagarsamy Pharmazie 59 2004 753
15. A. Kamal, and S. Sattur Indian J. Chem. 23(B) 1988 1293
16. Y. Zhohghna Zaghi 53 1993 45
17. G. Van Arman, L.M. Miller, and M.P.O. Malley J. Pharmacol. Exp. Ther. 90 1960 133
18. B. Dews Br. J. Pharmacol. 8 1953 46
19. W.L. Kuhn, and E.F. Van Mannen J. Pharmacol. Exp. Ther. 134 1961 60