Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3154-3156

  Takahashi, Eiki ^a   Hirano, Noriyuki ^a   Nagahara, Takashi ^a   Yoshikawa, Satoru ^a   Momen, Shinobu ^a   Yokokawa, Hiroshi ^a   Hayashi, Ryoji ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

Antagonist; Transient receptor potential vanilloid 1; TRPV1; VR1

Indexed keywords

ACETAMIDE DERIVATIVE; FUNCTIONAL GROUP; PHENOXYACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; CYSTITIS; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; IN VIVO STUDY; NONHUMAN; OVERACTIVE BLADDER; RAT; URINARY FREQUENCY;

ACETAMIDES; AMINOPYRIDINES; ANIMALS; CAPSAICIN; CYSTITIS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

RATTUS;

EID: 84877577945     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.016     Document Type: Article

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