Synthesis and biological evaluation of 68Ga labeled bis-DOTA-3,3′-(benzylidene)-bis-(1H-indole-2-carbohydrazide) as a PET tracer for in vivo visualization of necrosis

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3216-3220

  Prinsen, Kristof ^a   Cona, Marlein Miranda ^b   Cleynhens, Jan ^a   Vanbilloen, Hubert ^a   Li, Junjie ^b   Dyubankova, Natalia ^a   Lescrinier, Eveline ^a   Bormans, Guy ^a   Ni, Yicheng ^b   Verbruggen, Alfons ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF IMAGING AND PATHOLOGY   (Belgium)

Author keywords

Bis indole; Cell death; Gallium 68; Necrosis; PET

Indexed keywords

BIS TETRAXETAN 3,3 (BENZYLIDENE) BIS (1H INDOLE 2 CARBOHYDRAZIDE) GA 68; GALLIUM 68; INDOLE DERIVATIVE; PENTETIC ACID; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTORADIOGRAPHY; CELL DEATH; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; IN VIVO STUDY; MOUSE; NECROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; COORDINATION COMPLEXES; GALLIUM RADIOISOTOPES; HALF-LIFE; HETEROCYCLIC COMPOUNDS, 1-RING; MICE; NECROSIS; PENTETIC ACID; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 84877576586     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.127     Document Type: Article

References (16)

1. J.F. Kerr, A.H. Wyllie, and A. Currie Br. J. Cancer 26 1972 239
2. G. Majno, and I. Joris Am. J. Pathol. 146 1995 3
3. D. McConkey Toxicol. Lett. 99 1998 157
4. S.Y. Proskuryakov, A.G. Konoplyannikov, and V.L. Gabai Exp. Cell Res. 283 2003 1
5. C.B. Thompson, and W.X. Zong Genes Dev. 20 2006 1
6. N. Vanlangenakker, T. Vanden Berghe, D.V. Krysko, N. Festjens, and P. Vandenabeele Curr. Mol. Med. 8 2008 207
7. J. Kajstura, W. Cheng, K. Reiss, W.A. Clark, E.H. Sonnenblick, and S. Krajewski Lab. Invest. 74 1996 86
8. J.H. Garcia, K.F. Liu, and K.L. Ho Stroke 26 1995 636
9. N. Perek, O. Sabido, N. Le Jeune, N. Prevot, J.M. Vergnon, and A. Clotagatide Eur. J. Nucl. Med. Mol. Imaging 35 2008 1290
10. D. Zhou, W. Chu, D.L. Chen, Q. Wang, D.E. Reichert, and Rothfuss Org. Biomol. Chem. 7 2009 1337
11. Q.D. Nguyen, G. Smith, M. Glaser, M. Perumal, E. Arstad, and E.O. Aboagye Proc. Natl. Acad. Sci. U.S.A. 106 2009 16375
12. A. Reshef, A. Shirvan, A. Akselrod-Ballin, A. Wall, and I. Ziv J. Nucl. Med. 51 2010 837
13. 68Ga-PET Radiopharmacy 2007 Springer Berlin, Heidelberg p 215
14. Y. Ni, F. Chen, S. Mulier, X. Sun, J. Yu, and W. Landuyt Eur. Radiol. 16 2006 1031
15. K. Prinsen, M. De Saint-Hubert, J. Li, P. Vermaelen, L. Mortelmans, and G. Bormans J. Nucl. Med. 50 2009 92
16. M. De Saint-Hubert, F.M. Mottaghy, K. Vunckx, J. Nuyts, H. Fonge, K. Prinsen, S. Stroobants, L. Mortelmans, N. Deckers, L. Hofstra, C.P. Reutelingsperger, A. Verbruggen, and D. Rattat Bioorg. Med. Chem. 18 2010 1356