Site-specific labeling of 'second generation' annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivo

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1356-1363

  De Saint Hubert, Marijke ^a   Mottaghy, Felix M ^a   Vunckx, Kathleen ^a   Nuyts, Johan ^a   Fonge, Humphrey ^b   Prinsen, Kristof ^b   Stroobants, Sigrid ^a   Mortelmans, Luc ^a   Deckers, Niko ^c   Hofstra, Leo ^c   Reutelingsperger, Chris P M ^c   Verbruggen, Alfons ^b   Rattat, Dirk ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Annexin V; Apoptosis; Imaging; Technetium 99m; Tricarbonyl labeling

Indexed keywords

ALBUMIN PENTETATE TECHNETIUM TC 99M; FAS ANTIBODY; HYDRAZINONICOTINAMIDE ANXV TECHNETIUM 99M; LIPOCORTIN 5; PERTECHNETIC ACID TC 99M; PROTEIN; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIVER; MOUSE; NONHUMAN;

ANIMALS; ANNEXIN A5; APOPTOSIS; HEPATOCYTES; MICE; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

MUS;

EID: 75149124413     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.021     Document Type: Article

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