Cd4 and cd8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth

Journal of Virology

Volumn 87, Issue 10, 2013, Pages 6051-6054

  Liang, Xiaozhan ^a,b   Crepeau, Rebecca L ^c   Zhang, Weijun ^c   Speck, Samuel H ^b   Usherwood, Edward J ^c  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CANCER INHIBITION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL IMMORTALIZATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY TEST; GAMMAHERPESVIRINAE; GAMMAHERPESVIRUS 68; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; SURVIVAL TIME; TUMOR GROWTH; TUMOR IMMUNOLOGY; TUMOR VOLUME;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; MICE; MICE, INBRED C57BL; RHADINOVIRUS;

EID: 84877353055     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00375-13     Document Type: Article

References (17)

1. + T cells regulates chronic infection and immunopathology. J. Exp. Med. 205:669- 684.
2. Freeman ML, Burkum CE, Lanzer KG, Jensen MK, Ahmed M, Yager EJ, Flaño E, Winslow GM, Woodland DL, Blackman MA. 2011. Cutting edge: activation of virus-specific CD4 T cells throughout γ-herpesvirus latency. J. Immunol. 187:6180-6184.
3. + T-cell function and immune surveillance of murine gammaherpesvirus 68. J. Virol. 80:9159-9170.
4. Kim I-J, Flaño E, Woodland DL, Blackman MA. 2002. Antibodymediated control of persistent γ-herpesvirus infection. J. Immunol. 168: 3958-3964.
5. Lee KS, Groshong SD, Cool CD, Kleinschmidt-DeMasters BK, van Dyk LF. 2009. Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus-associated B cell lymphoproliferative disease. Cancer Res. 69:5481-5489.
6. Sparks-Thissen RL, Braaten DC, Kreher S, Speck SH, Virgin HW. 2004. An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection. J. Virol. 78:6827-6835.
7. Tibbetts SA, van Dyk LF, Speck SH, Virgin HW. 2002. Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. J. Virol. 76:7125-7132.
8. Tsai C-Y, Hu Z, Zhang W, Usherwood EJ. 2011. Strain-dependent requirement for IFN-α for respiratory control and immunotherapy in murine gammaherpesvirus infection. Viral Immunol. 24:273-280.
9. Weck KE, Dal Canto AJ, Gould JD, O'Guin AK, Roth KA, Saffitz JE, Speck SH, Virgin HW. 1997. Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. Nat. Med. 3:1346- 1353.
10. Liang X, Paden CR, Morales FM, Powers RP, Jacob J, Speck SH. 2011. Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen. PLoS Pathog. 7:e1002220. doi:10.1371/journal.ppat.1002220.
11. Obar JJ, Fuse S, Leung EK, Bellfy SC, Usherwood EJ. 2006. Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protection. J. Virol. 80:8303-8315.
12. Christensen JP, Cardin RD, Branum KC, Doherty PC. 1999. CD4+ T cell-mediated control of a γ-herpesvirus in B cell-deficient mice is mediated by IFN-γ. Proc. Natl. Acad. Sci. U. S. A. 96:5135-5140.
13. + T cells. J. Exp. Med. 184:863-871.
14. + T cells arise in the absence of CD4 help and compromise control of persistent virus. J. Immunol. 186:6218-6226.
15. Robertson KA, Usherwood EJ, Nash AA. 2001. Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes. J. Virol. 75:3480-3482.
16. Lacerda JF, Ladanyi M, Louie DC, Fernandez JM, Papadopoulos EB, O'Reilly RJ. 1996. Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice. J. Exp. Med. 183:1215-1228.
17. + T cells for the treatment of EBV-related tumors. J. Immunol. 184:5895-5902.