Possible involvement of A2A and A3 receptors in modulation of insulin secretion and β-cell survival in mouse pancreatic islets

General and Comparative Endocrinology

Volumn 187, Issue , 2013, Pages 86-94

  Ohtani, M ^a   Oka, T ^b   Ohura, K ^a  

^a OSAKA DENTAL UNIVERSITY   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Adenosine receptor; Cell viability; Insulin secretion; Pancreatic cells

Indexed keywords

ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE A2B RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; GLUCOSE; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; INSULIN RELEASE; MALE; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; HAMSTER; METABOLISM; PANCREAS ISLET; RAT; WESTERN BLOTTING; DRUG EFFECT;

ADENOSINE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CRICETINAE; GLUCOSE; IN SITU NICK-END LABELING; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; PURINERGIC P1 RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P1;

EID: 84877317631     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2013.02.011     Document Type: Article

References (33)

1. Andersson O., Adams B.A., Yoo D., Ellis G.C., Gut P., Anderson R.M., German M.S., Stainier D.Y. Adenosine signaling promotes regeneration of pancreatic β cells in vivo. Cell Metab. 2012, 15:885-894.
2. Bertrand G., Petit P., Bozen M., Henquin J.C. Membrane and intracellular effects of adenosine in mouse pancreatic β-cells. Am. J. Physiol. Endocrinol. Metab. 1989, 257:E473-E478.
3. 2-subtype adenosine receptor on pancreatic glucagon secreting cells. Br. J. Pharmacol. 1985, 86:565-569.
4. Donath M.Y., Ehses J.A., Maedler K., Schumann D.M., Ellingsgaard H., Eppler E., Reinecke M. Mechanisms of β-cell death in type 2 diabetes. Diabetes 2005, 54:S108-S115.
5. Fredholm B.B., Ijzerman A.P., Jacobson K.A., Linden J., Müller C.E. International union of basic and clinical pharmacology. LXXI. Nomenclature and classification of adenosine receptors-an update. Pharmacol. Rev. 2011, 63:1-34.
6. 1 subtype adenosine receptor on pancreatic insulin-secreting cells. Eur. J. Pharmacol. 1987, 136:109-112.
7. 1-receptor-mediated inhibition of insulin secretion. Br. J. Pharmacol. 1989, 96:3-4.
8. Hui H., Dotta F., Di Mario U., Perfetti R. Role of caspases in the regulation of apoptotic pancreatic islet cells death. J. Cell. Physiol. 2004, 200:177-200.
9. Iwatsuki K. Subtypes of adenosine receptors on pancreatic exocrine secretion in anaesthetized dogs. Fundam. Clin. Pharmacol. 2000, 14:203-208.
10. Jacobson K.A. Introduction to adenosine receptors as therapeutic targets. Handb. Exp. Pharmacol. 2009, 193:1-24.
11. Jacobson K.A., Hoffmann C., Cattabeni F., Abbracchio M.P. Adenosine-induced cell death: evidence for receptor-mediated signaling. Apoptosis 1999, 4:197-211.
12. 1 receptor deficiency causes increased insulin glucagon secretion in mice. Biochem. Pharmacol. 2007, 74:1628-1635.
13. Mandrup-Poulsen T. Apoptotic signal transduction pathways in diabetes. Biochem. Pharmacol. 2003, 66:1433-1440.
14. Molina-Arcas M., Casado F.J., Pastor-Anglada M. Nucleoside transporter proteins. Curr. Vasc. Pharmacol. 2009, 7:426-434.
15. Németh Z.H., Bleich D., Csóka B., Pacher P., Mabley J.G., Himer L., Vizi E.S., Deitch E.A., Szabó C., Cronstein B.N., Haskó G. Adenosine receptor activation ameliorates type 1 diabetes. FASEB J. 2007, 21:2379-2388.
16. Novak I. Purinergic receptors in the endocrine and exocrine pancreas. Purinergic Signal. 2008, 4:237-253.
17. Novak I., Hede S.E., Hanse M.R. Adenosine receptors in rat and human pancreatic ducts stimulate chloride transport. Pflugers Archiv. 2008, 456:437-447.
18. 3 adenosine receptor. J. Cell. Physiol. 2001, 186:19-23.
19. Ohtani M., Daly J.W., Oka T. Co-existence of muscarinic and nicotinic receptors and their functional interaction in mouse Beta-TC6 cells. Eur. J. Pharmacol. 2009, 604:150-157.
20. 2+ in mouse Beta-TC6 insulinoma cells. Cell Struct. Funct. 2009, 34:105-113.
21. Ohtani M., Ohura K., Oka T. Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells. Cell. Physiol. Biochem. 2011, 28:355-366.
22. Ohtani M., Oka T., Badyuk M., Xia Y., Kellar K.J., Daly J.W. Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. Mol. Pharmacol. 2006, 69:899-907.
23. 2+ mobilization and insulin secretion in mouse pancreatic islets. Purinergic Signal. 2008, 4:365-375.
24. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 1998, 50:413-492.
25. 1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin. Life Sci. 2009, 85:470-476.
26. Satoh A., Satoh K., Masamune A., Yamagiwa T., Shimosegawa T. Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. Pancreas 2002, 24:75-82.
27. Srinivasan S., Ohsugi S.M., Liu Z., Fatrai S., Bernal-Mizrachi E., Permutt M.A. Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3β in mouse insulinoma cells. Diabetes 2005, 54:968-975.
28. Tait S.W.G., Green D.R. Caspase-independent cell death: leaving the set without the final cut. Oncogene 2008, 27:6452-6461.
29. Tonnesen M.F., Grunet L.G., Friberg J., Cardozo A.K., Billestrup N., Eijiriki D.L., Størling J., Mandrup-Poulsen T. Inhibition of nuclear factor-κB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells. Endocrinology 2009, 150:4049-4103.
30. 45Ca uptake. Cell Biochem. Funct. 2008, 26:833-843.
31. Yamada S., Komatsu M., Sato Y., Yamaguchi K., Kojima I., Aizawa T., Hoshizume K. Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell. Endocrinology 2002, 143:4203-4209.
32. Yang G.K., Squires P.E., Tian F., Kieffer T.J., Kwok Y.N., Dale N. Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets. Islets 2012, 4:64-70.
33. 1 receptor antagonism on insulin secretion from rat pancreatic islets. Physiol. Res. 2011, 60:905-911.