Subetta treatment increases adiponectin secretion by mature human adipocytes in vitro

International Journal of Endocrinology

Volumn 2013, Issue , 2013, Pages

  Nicoll, Jim ^a   Gorbunov, Evgeniy A ^b   Tarasov, Sergey A ^b   Epstein, Oleg I ^b  

^a Zen Bio Inc   (United States)

^b OOO NPF Materia Medica Holding   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ANTIDIABETIC AGENT; DIMETHYL SULFOXIDE; INSULIN RECEPTOR; PLACEBO; RECEPTOR SUBUNIT; ROSIGLITAZONE; SUBETTA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADULT; ANTIDIABETIC ACTIVITY; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; QUANTITATIVE ASSAY;

EID: 84877301844     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2013/925874     Document Type: Article

References (18)

1. WHO Media Center, Diabetes. Fact sheet no. 312, 2012, http://www.who.int/mediacentre/factsheets/fs312/en/index.html
2. Inzucchi S. E., Bergenstal R. M., Buse J. B., Diamant M., Ferrannini E., Nauck M., Peters A. L., Tsapas A., Wender R., Matthews D. R., Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012 35 6 1364 1379
3. Su H., Lau W. B., Ma X. L., Hypoadiponectinaemia in diabetes mellitus type 2: molecular mechanisms and clinical significance. Clinical and Experimental Pharmacology and Physiology 2011 38 897 904
4. Shehzad A., Iqbal W., Shehzad O., Lee Y. S., Adiponectin: regulation of its production and its role in human diseases. Hormones 2012 11 8 20
5. Luo R., Li X., Jiang R., Gao X., Lü Z., Hua W., Serum concentrations of resistin and adiponectin and their relationship to insulin resistance in subjects with impaired glucose tolerance. Journal of International Medical Research 2012 40 621 630
6. Stumvoll M., Goldstein B. J., van Haeften T. W., Type 2 diabetes: principles of pathogenesis and therapy. The Lancet 2005 365 9467 1333 1346 2-s2.0-17044386953 10.1016/S0140-6736(05)61032-X
7. Arner P., The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends in Endocrinology and Metabolism 2003 14 3 137 145 2-s2.0-0037732481 10.1016/S1043-2760(03)00024-9 (Pubitemid 36733912)
8. Arora S., Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World Journal of Diabetes 2010 1 68 75
9. Bastard J. P., Maachi M., Lagathu C., Kim M. J., Caron M., Vidal H., Capeau J., Feve B., Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network 2006 17 1 4 12 2-s2.0-33745896155
10. Martins A. R., Nachbar R. T., Gorjao R., Vinolo M. A., Festuccia W. T., Lambertucci R. H., Cury-Boaventura M. F., Silveira L. R., Curi R., Hirabara S. M., Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids in Health and Disease 2012 11, article 30
11. Tilg H., Moschen A. R., Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 2006 6 10 772 783 2-s2.0-33748992313 10.1038/nri1937 (Pubitemid 44453463)
12. Dunmore S. J., Brown J. E., The role of adipokines in beta-cell failure of type 2 diabetes. Journal of Endocrinology 2013 216 T37 T45
13. Epstein O. I., Release-activity: a long way from the phenomenon to new drugs. Bulletin of Experimental Biology and Medicine 2012 154 1 54 58
14. Kheyfets I. A., Spasov A. A., Voronkova M. P., Dugina J. L., Epstein O. I., Study of hypoglycemic activity of Subetta and rosiglitazone on the model of streptozotocin-induced diabetes mellitus in rats. Bulletin of Experimental Biology and Medicine 2012 153 54 56
15. Gorbunov E. A., Tarasov S. A., Epstein O. I., Bailbe D., Philippe E., Portha B., The novel oral drug subetta exerts anti-diabetic effect in the diabetic GK/Par rat. Diabetologia 2012 55 supplement 1 S365 S366
16. Youngren J. F., Regulation of insulin receptor function. Cellular and Molecular Life Sciences 2007 64 7-8 873 891 2-s2.0-34247140171 10.1007/s00018-007-6359-9 (Pubitemid 46597750)
17. Li M., Youngren J. F., Manchem V. P., Kozlowski M., Zhang B. B., Maddux B. A., Goldfine I. D., Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells. Diabetes 2001 50 10 2323 2328 2-s2.0-0035486843 (Pubitemid 33641918)
18. Zhang B., Salituro G., Szalkowski D., Li Z., Zhang Y., Royo I., Vilella D., Díez M. T., Pelaez F., Ruby C., Kendall R. L., Mao X., Griffin P., Calaycay J., Zierath J. R., Heck J. V., Smith R. G., Moller D. E., Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science 1999 284 5416 974 977 2-s2.0-0033532347 10.1126/science.284.5416.974 (Pubitemid 29288438)