Positive association between testosterone, blood pressure, and hypertension in women: Longitudinal findings from the Study of Health in Pomerania

Journal of Hypertension

Volumn 31, Issue 6, 2013, Pages 1106-1113

  Ziemens, Benedict ^a   Wallaschofski, Henri ^a,d   Völzke, Henry ^b,d   Rettig, Rainer ^c   Dörr, Marcus ^a,d   Nauck, Matthias ^a,d   Keevil, Brian G ^e   Brabant, Georg ^e   Haring, Robin ^a,d  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b Section Study of Health in Pomerania Clinical Epidemiological Research Institute for Community Me   (Germany)

^c Institute of Physiology and Pathophysiology   (Germany)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

blood pressure; hypertension; sex hormones; testosterone; women

Indexed keywords

ANDROSTENEDIONE; SEX HORMONE BINDING PROTEIN; TESTOSTERONE;

ADULT; AGED; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RISK; COMORBIDITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GERMANY; HORMONE BLOOD LEVEL; HUMAN; HYPERTENSION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MENOPAUSE; PHYSICAL ACTIVITY; POPULATION BASED CASE CONTROL STUDY; PREVALENCE; PRIORITY JOURNAL; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; WOMEN'S HEALTH;

EID: 84877265764     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3283603eb1     Document Type: Article

References (43)

1. Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 1996; 275:1571-1576.
2. Stokes J 3rd, Kannel WB, Wolf PA, D'Agostino RB, Cupples LA. Blood pressure as a risk factor for cardiovascular disease. The Framingham Study: 30 years of follow-up. Hypertension 1989; 13:I13-18.
3. Brand JS, van der Schouw YT. Testosterone, SHBG and cardiovascular health in postmenopausal women. Int J Impot Res 2010; 22:91-104.
4. Kienitz T, Quinkler M. Testosterone and blood pressure regulation. Kidney Blood Press Res 2008; 31:71-79.
5. Torkler S, Wallaschofski H, Baumeister SE, Volzke H, Dorr M, Felix S, et al. Inverse association between total testosterone concentrations, incident hypertension and blood pressure. Aging Male 2011; 14:176-182.
6. Gannage-Yared MH, Chedid R, Abs L. Relation between androgens and cardiovascular risk factors in a young population. Clin Endocrinol (Oxf) 2011; 74:720-725.
7. Maturana MA, Breda V, Lhullier F, Spritzer PM. Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women. Metabolism 2008; 57:961-965.
8. Huisman HW, Schutte AE, Van Rooyen JM, Malan NT, Malan L, Schutte R, Kruger A. The influence of testosterone on blood pressure and risk factors for cardiovascular disease in a black South African population. Ethn Dis 2006; 16:693-698.
9. Lambrinoudaki I, Christodoulakos G, Rizos D, Economou E, Argeitis J, Vlachou S, et al. Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women. Eur J Endocrinol 2006; 154:907-916.
10. Phillips GB, Tuck CH, Jing TY, Boden-Albala B, Lin IF, Dahodwala N, Sacco RL. Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in Hispanic postmenopausal women. Diabetes Care 2000; 23:74-79.
11. Haffner SM, Newcomb PA, Marcus PM, Klein BE, Klein R. Relation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women. Am J Epidemiol 1995; 142:925-934.
12. Korhonen S, Hippelainen M, Vanhala M, Heinonen S, Niskanen L. The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled communitybased study. Fertil Steril 2003; 79:1327-1334.
13. Patel SM, Ratcliffe SJ, Reilly MP, Weinstein R, Bhasin S, Blackman MR, et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2009; 94:4776-4784.
14. Khatibi A, Agardh CD, Nyberg P, Lidfeldt J, Samsioe G. Blood pressure in middle-aged women: are androgens involved? A populationbased study of Swedish women-the Women's Health in the Lund Area study. J Hypertens 2007; 25:2044-2050.
15. Phillips GB, Jing TY, Laragh JH. Serum sex hormone levels in postmenopausal women with hypertension. J Hum Hypertens 1997; 11:523-526.
16. Haring R, Hannemann A, John U, Radke D, Nauck M, Wallaschofski H, et al. Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metabol 2012; 97:408-415.
17. Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, et al. Cohort profile: the Study of Health in Pomerania. Int J Epidemiol 2011; 40:294-307.
18. Alte D, Luedemann J, Rose HJ, John U. Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the Study of Health in Pomerania (SHIP). Alcohol Clin Exp Res 2004; 28:931-940.
19. Schwarz S, Volzke H, Alte D, Schwahn C, Grabe HJ, Hoffmann W, et al. Menopause and determinants of quality of life in women at midlife and beyond: the Study of Health in Pomerania (SHIP). Menopause 2007; 14:123-134.
20. Völzke H, Schwarz S, Baumeister SE, Wallaschofski H, Schwahn C, Grabe HJ, et al. Menopausal status and hepatic steatosis in a general female population. Gut 2007; 56:594-595.
21. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289:2560-2572.
22. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25:1105-1187.
23. Thienpont LM, Van Uytfanghe K, Blincko S, Ramsay CS, Xie H, Doss RC, et al. State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandemmass spectrometry. Clin Chem 2008; 54:1290-1297.
24. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84:3666-3672.
25. McCullagh P, Nelder JA. Generalized linear models, 2nd ed. London: Chapman & Hall/CRC; 1989.
26. Afifi AA, Kotlerman JB, Ettner SL, Cowan M. Methods for improving regression analysis for skewed continuous or counted responses. Ann Rev Public Health 2007; 28:95-111.
27. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007; 370:1453-1457.
28. Perry A, Wang X, Goldberg R, Ross R, Jackson L. Racial disparities between the sex steroid milieu and the metabolic risk profile. J Obes 2010; 2010. 174652. doi: 10.1155/2010/174652. Epub 2010 Jul 8.
29. Moal V, Mathieu E, Reynier P, Malthiery Y, Gallois Y. Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques. Clin Chim Acta 2007; 386:12-19.
30. Vesper HW, Botelho JC. Standardization of testosterone measurements in humans. J Steroid Biochem Mol Biol 2010; 121:513-519.
31. Ayala C, Steinberger E, Sweeney A, Mueller WH, Waller DK, Hardy R, et al. The relationship of serumandrogens and ovulatory status to blood pressure in reproductive-age women. AmJ Hypertens 1999; 12:772-777.
32. Chen MJ, Yang WS, Yang JH, Chen CL, Ho HN, Yang YS. Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome. Hypertension 2007; 49:1442-1447.
33. Mueller A, Kiesewetter F, Binder H, Beckmann MW, Dittrich R. Longterm administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals. J Clin Endocrinol Metab 2007; 92:3470-3475.
34. Ling S, Komesaroff PA, Sudhir K. Cardiovascular physiology of androgens and androgen testosterone therapy in postmenopausal women. Endocr Metab Immune Disord Drug Targets 2009; 9:29-37.
35. Shufelt CL, Braunstein GD. Safety of testosterone use in women. Maturitas 2009; 63:63-66.
36. Wu CC, Schwartzman ML. The role of 20-HETE in androgenmediated hypertension. Prostaglandins Other Lipid Mediat 2011; 96: 45-53.
37. Singh H, Schwartzman ML. Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Pharmacol Rep 2008; 60:29-37.
38. Reckelhoff JF, Yanes LL, Iliescu R, Fortepiani LA, Granger JP. Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease. Am J Physiol Renal Physiol 2005; 289:F941-948.
39. Nakagawa K, Marji JS, Schwartzman ML, Waterman MR, Capdevila JH. Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. Am J Physiol Regul Integr Comp Physiol 2003; 284:R1055-1062.
40. Seachrist D, Dunphy G, Daneshvar H, Caplea A, Milsted A, Ely D. Testosterone increases blood pressure and cardiovascular and renal pathology in spontaneously hypertensive rats. Blood Press 2000; 9: 227-238.
41. Empen K, Lorbeer R, Dorr M, Haring R, Nauck M, Glaser S, et al. Association of testosterone levels with endothelial function in men: results from a population-based study. Arterioscler Thromb Vasc Biol 2012; 32:481-486.
42. Lima R, Wofford M, Reckelhoff JF. Hypertension in postmenopausal women. Curr Hyperten Rep 2012; 14:254-260.
43. Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health 2005; 95 (Suppl 1):S144-S150.